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Candles Longidase in gynecology: the composition and properties of the drug, the purpose and contraindications

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In the 90s of the last century in Russia a unique means was patented that can restore female fertility - Longidase candles. Instructions for use in gynecology of this drug is useful to read to all those women who plan to use it for the treatment and prevention of diseases of the pelvic organs.

The composition and properties of the drug

The main active component of Longidase is hyaluronidase enzyme. In addition to it, the composition of the candles includes bromide azoxymere, which protects the active substance from destruction, increases its action time and increases the overall effectiveness of treatment. Suppositories have the following properties:

  • strengthen local immunity

  • relieve inflammation
  • neutralize the negative effects of free radicals,
  • toxic compounds are eliminated from the body,
  • reduce the severity of adhesive processes in the pelvic zone,
  • eliminate puffiness.

The active substance does not accumulate in the body, and acts only on the affected areas.

Indications for use of Longidase

In gynecology, suppositories are used for the treatment and prevention of:

  • pathological proliferation of connective tissue caused by inflammation of the pelvic organs,

  • adhesive processes, developing after gynecological operations and other medical procedures,
  • intrauterine adhesions,
  • endometriosis (pathological growth of the inner layer of the uterus),
  • complications of sexually transmitted diseases,
  • chronic endometritis (septic inflammation of the muscular and internal mucous layer of the uterine wall).

The tool is used in the treatment of infertility, which arose against obstruction of the fallopian tubes.

Terms of use of candles

In gynecological practice, it is usually prescribed 1 suppository of Longidaza rectally or vaginally 1 every 3 days during the month. In exceptional cases, doctors increase the standard dosage. So, when detecting the neglected forms of the disease, patients are recommended to use candles daily.

When introducing a suppository, you need to follow the following algorithm of actions:

  • take care of clean hands and anogenital zone,
  • lie on your side and pull your knees up to your chest
  • extract the drug from the contour packaging,
  • insert the tool deeply into the anal passage or vagina.

In order to push the candle to the desired depth, you can use a special applicator. After the procedure, you need to spend at least an hour in bed.

Candles Longidase can be used simultaneously with the reception of antiviral, antibacterial, bronchodilator and antifungal agents. However, it should be borne in mind that suppositories may slightly enhance the pharmacological effect of these drugs.

Analogs means

Longidase is a rather expensive drug. Therefore, women who have indications for its use, very often seek a cheaper replacement for it. The most similar in composition and form analogue of this tool Lidaza candles are counted - drug produced from the testes of livestock. The composition of these suppositories includes hyaluronidase and a complex of excipients that enhance the therapeutic effect of the basic component. Candles containing Lidazu have one major drawback - they are not produced on an industrial scale. Usually they are prepared by pharmacists or pharmacists in pharmacies by prescription.

These candles are much cheaper than Longidase. At the same time, they cannot be considered a complete analogue of the original drug: there is no very important component in their composition - azoxymere bromide. Therefore, if for the treatment of inflammatory, adhesive or other pathological processes in the pelvic area, the doctor prescribes Longidaz suppositories, it makes no sense to experiment with other drugs. Self-medication can trigger the development of dangerous complications.

Contraindications to the use of candles

Candles Longidase and their analogues have a number of contraindications. The grounds for refusing to use them can be:

  • breastfeeding period,

  • pregnancy,
  • age up to 12 years
  • hypersensitivity to hyaluronidase and auxiliary components of the drug,
  • hemorrhage in the eye (in the space between the retina and the lens),
  • pulmonary hemorrhage
  • coughing up sputum with bloody impurities,
  • impaired renal function, liver,
  • malignant tumors.

Ignoring contraindications when using suppositories can lead to the most unexpected consequences for the body. Therefore, it is very important to coordinate the use of this drug with your doctor.

Candles Longidase in gynecology: use and contraindications

Domestic scientific figures have patented a drug with proven efficacy for the treatment of inflammatory processes of the urogenital area in men and women, also used to treat complications of gynecological diseases.

This medicine is called “Longidase”, it is produced as a candle with a dosage of 3000ME or an injection solution, but candles are most often used in gynecology.

Operating principle

Candles "Longidase" have among the components as the main active component of the modulated enzyme longidase, which promotes hydrolysis of edematous tissues, localizes inflammatory processes, promotes the production of its own collagen, tissue repair.

It is noteworthy that longidase acts only on the affected tissues, without affecting healthy ones. In addition, candles remove toxins, as well as tissue decomposition products during treatment.

Contraindications and side effects

Like any medicine, this remedy has side effects, as well as a number of contraindications. Clinical studies show that it does not cause side effects, with the exception of individual allergic reactions.

When taking candles you need to take into account their effect as part of the complex therapy of the disease. So while taking it with antibiotics or painkillers, longidase increases their effect.

With simultaneous therapy with antihistamine spectrum drugs, longidase as a stimulator of local immunity becomes ineffective due to the suppression of the body's immune responses with drugs that localize allergic reactions.

Despite the fact that the "Longidase" candles are a safe medicine, there are a number of contraindications in which the use of the drug is not recommended:

  • with infectious diseases of the acute stage,
  • in the presence of malignant neoplasms,
  • in people with adrenal dysfunction,
  • in children whose age has not reached 12 years
  • during pregnancy and lactation.

Drug should not be abused. When overdose occurs, chills can occur, there has been a decrease in pressure and an increase in body temperature. "Longidase" does not affect the ability to drive vehicles. The period of elimination from the body ranges from two to three days, it is excreted by the kidneys.

How to apply?

Candles "Longidase" is used rectally or vaginally, as in the individual treatment with the drug, and as part of a comprehensive treatment.

For rectal administration of suppositories, pre-emptying of the bowels or cleansing procedures are recommended to achieve the best effect.

When the vaginal route of administration is recommended to do this lying because of the anatomical features of the female body. If the period of treatment accounts for menstruation, suppository "Longidase" is administered rectally, but this reduces the effectiveness of treatment.

For better absorbability, it is better to administer suppositories before bedtime while lying down. The general course of admission is about 20 days. Despite the fact that the candles "Longidaza" dispensed in pharmacies without a prescription, do not self-medicate.

The dosage and duration of therapeutic reception of candles should be determined by the doctor.

Analogs and prices

Similar to "Longidase" in composition and action of the drug is the drug "Lidaza".

Having the same enzyme among the active ingredients, as well as having a similar effect, there are no suppositories among the release forms of the drug Lidaza, Lidaza is available only as a powder for preparing a solution for injection, drops or solution for inhalation. The price of the drug is low, it ranges from 200 to 500 rubles.

Having as a main active ingredient also haluronidase, “Ronidaza” is available only in powder, and is used topically to treat allergic reactions and prevent the appearance of scars in injuries or in the postoperative period. The drug is applied to a cloth moistened with saline, which is applied to the affected part of the body. Prices for Ronidaz powder range from 350 to 600 rubles. Prices may vary, because This analogue rarely goes on sale in pharmacies.

"Polyoxidonium" is another analogue of Longidase candles. They are similar in action, have the same indications for use. Candles "Polyoxidonium" are appointed to enhance local immunity and treatment of inflammatory diseases.

As well as candles "Longidase", "Polyoxidonium" can be used rectally or vaginally. The difference lies in the absence among the therapeutic effects of the prevention and treatment of scars and adhesions. But there is a form of release in the form of candles, which can be used to treat children from 6 years.

In pharmacies "Polyoxidonium" in the form of candles costs from 980 rubles.

Candles "Longidase" have a great advantage in comparison with analogues due to the complex treatment of not only the cause of the disease, but also its consequences. Not having analogues on the therapeutic effects on the body, candles "Longidase" are in pharmacies and online stores from 1,400 rubles.

When deciding on the choice of a drug for treating a whole range of problems, you should consult a doctor and conduct a preliminary examination to identify contraindications.

Only a doctor can choose the optimal dosage and duration of treatment.

Release form

torpedo-shaped suppositories, hygroscopic porous mass of white, yellow-white or brownish color, with a slight specific smell of cocoa. Marble coloration is acceptable. Plastic casing, carton.

Active component:

Hyaluronidase conjugate with high molecular weight water-soluble carrier (Polyoxidonium) 3000 IU

Auxiliary components

Pharmacodynamics

Longidase is an artificially synthesized chemical compound of hyaluronidase (a proteolytic enzyme) with a high molecular weight carrier, which has a pronounced immunomodulatory activity.

This drug has a spectrum of pharmacological properties characteristic of drugs with hyaluronidase activity.

It helps to increase permeability and improve trophism of tissues, speeds up the resorption of hematomas, eliminates adhesions and contractures, reduces swelling, and normalizes joint mobility.

The maximum therapeutic effect of Longidase is observed when used at the earliest stages of development of the pathological process.

The drug retains its enzymatic activity at 37 ° C for 20 days, binds the iron ions released during hydrolysis of glycosaminoglycans, stimulates collagen synthesis and hyaluronidase inhibitors, and inhibits the synthesis of connective tissue components.

The drug is well tolerated by patients, does not cause general and local allergic reactions, does not have carcinogenic, mutagenic, embryotoxic and teratogenic properties, does not slow down the recovery of bone tissue, does not worsen the patient's condition after surgery or infectious diseases.

Under the influence of Longidase, the bioavailability of other drugs increases, the effect of local anesthetics is enhanced.

Pharmacokinetics

With rectal administration of the suppository, the active component of the drug is well absorbed into the systemic circulation, reaching peak plasma concentrations within 60 minutes. With vaginal and rectal use, the bioavailability of the drug reaches 70%. It penetrates the hematoencephalic, hematoplacental and ophthalmologic barrier.

Hyaluronidase in the body undergoes hydrolysis, disintegrates into monomers and is excreted by the kidneys along with urine (approximately 40-45% during the first day), as well as through the intestines (3%). The period of complete elimination of the drug is 42-84 hours.

Drug properties

The main active ingredient is longidase. It consists of the enzyme hyaluronidase and a special carrier component. This compound gives the drug a high resistance to harmful factors and prolongs the effect of the drug. Thanks to these properties, suppositories have greater efficiency in therapy. They are very different from many medicines that have Hayuronidase in their composition.
For Longidis disease, the following are characteristic:

  • Have an antioxidant effect,
  • Have anti-inflammatory effects,
  • Contribute to increased hypersensitivity reactions,
  • Help with microcirculation of fluid in the extracellular space,
  • Helps to strengthen the elimination of toxins from body tissues,
  • Reduce the obvious signs of adhesive processes in the internal female genital organs.

Popular analog

Longidase is not a cheap drug. Therefore, many women are looking for cheaper analogues. Lidaza is considered the most common replacement. However, it is impossible to call this medication a full-fledged analogue, since the Longidasis candles in gynecology are equal in composition to an almost unique drug.

Lidaza is available as an injection. Helps to reduce the swelling of tissues, contributes to their permeability and elasticity. Well softens scars. Use of the agent during breastfeeding and pregnancy is prescribed exclusively by a doctor. Therapy is carried out under the strict supervision of a specialist.

To be carried away by the drug is prohibited. As the following symptoms may occur:

  1. Vomiting
  2. Painful heart palpitations,
  3. Nausea,
  4. Slight swelling,
  5. Shiver,
  6. Headache,
  7. Loss of balance

The relationship of adhesions and infertility

Longidase with infertility is assigned to remove adhesions. This is what is called a whitish film, which is formed on the internal genitals. It mainly closes the fallopian tubes. Adhesions begin when the body tries to deal with the following problems:

  • inflammation of the appendages,
  • infection of the genital organs,
  • trauma to the uterus.

Adhesions make it possible to stop a purulent inflammatory, infectious process. They have a protective function. However, dense formations seriously impair fertilization function and may interfere with the continuation of the species. Adverse effects of adhesions:

  • prevent the sperm from passing through the fallopian tubes,
  • do not allow to increase the uterus during the development of pregnancy,
  • impede the release of the egg required for fertilization,
  • interfere with the meeting of zygote mother and father.

As a result, adhesions interfere not only with the conception of a child, but also with the development of the embryo, since they often block the processes occurring in the uterus. But this body necessarily increases during pregnancy. The process of formation of adhesions is reversible.

Pregnancy after the removal of the film comes quickly, and, despite the illness, the patient no longer suffers from infertility. You can remove adhesions surgically. But after surgery, they may occur again. The best way to combat these formations is to use Longidase suppositories for rectal or vaginal administration.

The composition of the candles and injections Longidase

Suppositories Longidase - suppositories for infertility, not the only form of release of the drug. Ampoules for intravenous administration are also produced. However, in gynecology, the practice of using candles is more common - they have a directional effect and actively influence the focus of the disease.

The suppository includes:

  • Excipients,
  • hyaluronidase.

Hyaluronidase, which is included in Longididase suppositories for infertility, is a substance associated with hyaluronic acid. It activates the process of decay of adhesions and easily removes the film, restores the softness of the fallopian tubes, stimulates the function of natural regeneration.

The auxiliary substance helps to gently introduce the drug in the affected area, increases the absorption of the active compound.

Pharmacological and pharmacokinetic action

You can use candles without fear of serious side effects, since the action is clearly directed. The drug is absorbed only in the genital area and is rapidly excreted, without affecting the system functions and internal organs.

Hyaluronidase has the following effects:

  • stimulates the decay of adhesions
  • removes slags and toxins (antioxidant),
  • inflammatory processes stop,
  • activates tissue regeneration after surgery.

Благодаря такому спектру положительных действий препарат часто назначают пациенткам с нарушениями работы половых органов. Лонгидаза считается одним из самых безопасных и эффективных средств.

Применение свечей Лонгидаза в гинекологии

Лекарство назначается при различных поражениях половых органов. These are not only processes that threaten the fertility of the woman, but also any other abnormalities that can result in scarring and inflammation. Indications for use of the drug:

  • recovery period after surgery,
  • inflammation of the appendages,
  • chronic endometritis,
  • adhesions and cicatricial formations in the genital area,
  • infertility caused by spikes.

The drug Longidase is prescribed to patients from the age of 12, with the exception of people with impaired renal function or pulmonary hemorrhage.

Longidis disease for inflammation of the appendages

In the pelvic inflammatory processes in the appendages increases the risk of infertility. To reduce the likelihood of reduced fertility and the removal of these organs, suppositories are prescribed.

Soft tissues in gynecology are restored by the introduction of Longidase and other auxiliary drugs. Suppositories - only part of complex therapy. A month later, the inflammation stops, the state of the tissues normalizes.

Effective remedy for adhesions

In gynecology, the treatment and prevention of adhesions is mainly carried out with the help of Longidase vaginal suppositories. The drug is prescribed because it has all the necessary actions against adhesions:

  • destroys disturbing education,
  • prevents reappearance
  • gently restores surrounding tissue.

Completely get rid of adhesions after several courses of the drug. Then the risk and an inflammation of a small basin decreases.

Immunomodulatory effects

In case of inflammatory diseases of the internal organs, it is very important to improve the defense mechanisms. Therapy completely helps, only if after getting rid of adhesions and inflammations permanent immunity will be acquired against urogenital lesions.

"Longidase" improves the condition of the soft tissues of the genital organs, thereby increasing protection against infections, inflammation and viral lesions.

Candles "Longidase" for prostatitis

Suppositories may be prescribed in urology for the treatment of chronic prostatitis. Especially often they are written out at stagnant lesions of the prostate gland. Hyaluronidase heals damaged tissue, reduces inflammation. The main advantage that the drug has is that it improves blood circulation in the gland area, which helps get rid of puffiness, pain, inflammation.

The use of Longidaze from chronic prostatitis is safe for men, does not lead to the defeat of healthy tissues, helps to get rid of infertility. It is recommended to use rectal suppositories instead of injections.

Use of Longidis Injections

Longidase needles are used for a month. It is desirable that the injection put a doctor. This method of therapy is usually prescribed for inpatient treatment after surgery. A month after therapy with injections, the substance is excreted from the body, and it is forbidden to take similar drugs.

Suppositories are administered rectally or vaginally. They should be used regularly - every day or every three days, depending on the severity of the inflammation.

The standard course of treatment with candles "Longidase" - 20 days, but if necessary, it can be increased to 60 days. Repeated patience is allowed, but only 3 months after the last course.

Drug benefits

"Longidase" has several actions at once, which is its main advantage. Only this drug gives simultaneously many effects:

  • anti-inflammatory,
  • cleansing,
  • therapeutic (elimination of adhesions after surgery),
  • regenerating.

Another advantage that has treatment with the help of "Longidase" - the focus of action. There is no need to fear that the active substance enters the bloodstream and will have a negative effect on the body (an exception is the use of injections).

The drug quickly affects the disease and eliminates it without obvious side effects.

Side effects

The list of side effects of a drug like Longidase is small. Most patients do not suffer from any discomfort. If you exceed the dosage may occur:

  • dizziness
  • decreased libido,
  • headaches,
  • burning sensation in the genital area.

If the admission rules are followed, violations rarely occur and most often consist in allergic reactions to the components of the composition. They can be expressed in swelling, mild rash. When allergies are detected, the drug must be replaced with an analogue.

Elena, 32 years old: “A year ago I was diagnosed with endometritis. Applied "Longidase" candles every three days for 2 months. Introduced vaginally. The ultrasound specialist noticed the effect in a month, and after two, the inflammatory process practically stopped. Three months later I underwent a second course, after which I was completely cured. I recommend this drug to anyone who wants to quickly get rid of the problems of the reproductive system. "

Anastasia, 23 years old: “I was prescribed suppositories after uterine surgery. There was a high probability of negative scarring. She passed three courses for 30 days with a break of 2.5 months. At first, the effect was hard to notice: healing had just begun. Because of the drug often felt dizzy. But by the third round, it was already noticeable that the recovery had gone as it should. After the last course, the risk of formation of adhesions completely disappeared. I am grateful to the doctor for delivering me from possible complications and infertility by prescribing Longididase. ”

Dosage and administration

The enzyme preparation Longidase in the form of suppositories is recommended for intraviginal (intravaginal) and rectal administration. Rectal use of 1 candle for the night, after cleansing the intestines. Intravaginally - 1 time per day, also before bedtime (suppository should be administered in a supine position). The full therapeutic course requires 10-20 candles.

The treatment regimen may be corrected by the attending physician depending on the duration of the disease, the stage and severity of the pathological process. In some cases, suppositories can be used with breaks of 1-2-3 days.

In urology, the drug is recommended to be used every other day (10 injections), then another 10 times with an interval of 2-3 days. Total for the course of treatment requires 20 suppositories.

In dermatology and venereology, it is recommended to use 1 suppository in 1–2 days, a total of 10–15 injections.

In gynecology - intravaginally or rectally 1 time in 2 days. Only 10 introductions.

In phthisiology and pulmonology - 10-20 injections, 1 candle in 2-4 days.

In surgery - 10 injections, 1 suppository in 2 days.

A second course of treatment with an enzyme preparation can be prescribed for medical reasons no earlier than after 3 months. As a drug for long-term maintenance therapy, Longidase is used for 3-4 months, 1 time in 5-7 days.

Drug interactions

With simultaneous use of the drug with salicylates, ACTH, estrogen, cortisone, or antihistamines, the effectiveness of hyaluronidase is reduced.

Longidase (suppositories) is compatible with antifungal, antiviral, antibacterial agents, cytostatics and bronchodilators.

When conducting a combined treatment should take into account the fact that it is possible to increase the absorption and enhance the systemic effect of drugs.

special instructions

With the development of an allergic reaction, the use of the drug should be canceled. If it is necessary to use Longidase in the form of suppositories against the background of exacerbation of the infectious process, it is necessary to simultaneously take antimicrobial drugs.

There is no evidence of the effect of Longidase on the ability to drive a car or perform work requiring increased concentration of attention and psychomotor speed.

Drug description

The drug Longidase is produced in the Russian Federation by LLC NPO Petrovaks Farm. The company has a consistently high quality of products. It produces drugs that since 1996 comply with all quality guarantees. Longidase is an enzyme agent with proteolytic activity. The active ingredient of the drug - Bovgialuronidaza azoksimer.

This substance is a proteolytic enzyme that breaks down protein molecules and promotes the resorption of contractures, scars and adhesions. The most effective action of Longidase in the early stages of the pathological process.

In addition to the proteolytic action, the drug has anti-inflammatory, antioxidant and immunomodulatory effects.

Longidase is an artificially synthesized chemical compound of hyaluronidase (a proteolytic enzyme) with a high molecular weight carrier, which has a pronounced immunomodulatory activity.

Instructions for use Longidase in the form of candles informs about the high enzymatic activity of the substance on the body for a long time. The drug is used for a progressive increase in the number of connective tissue cells, which entails their massive growth in various organs.

Mechanism of action

In any connective tissue contains hyaluronic acid, which is one of its most important components. If inflammation occurs or after surgery, some of the tissues may be replaced by connective tissue. Under certain conditions, these tissues suffer from hypoxia, they lack the necessary nutrients, including hyaluronic acid. As a result, a scar or spike is formed.

Hyaluronidase, affecting this acid, as the main substrate of connective tissue, accelerates the movement of fluid filling the space between the cells and improves the permeability of tissue barriers. In addition, it increases tissue elasticity, reduces swelling and helps the resorption of exudate formed during inflammation.

The reasons for the use in the gynecology of the drug Longidase

All inflammatory foci in the human body over time are separated from healthy tissues and organs by so-called adhesions. Adhesions consist of connective tissue structures that delimit the inflammation and reduce the risk of spreading the infection to nearby organs and tissues. In gynecology, the problem of adhesive disease is almost in the first place, since the appearance of adhesions for a woman has ambiguous consequences. In addition to these positive properties, connective tissue yarns and films have negative qualities:

  1. Drugs penetrate very poorly through the adhesions, which increases the recovery time.
  2. Adhesions glue closely spaced organs together. Complications of adhesions may be intestinal obstruction, displacement of the uterus, ectopic pregnancy, infertility.

Thus, adhesions in the fallopian tubes prevent the egg from passing into the uterus after ovulation, which makes it impossible to fertilize it and, therefore, conceive a child. The drug Longidase splits the adhesions formed as a result of inflammation, enhances the local effect of other medicines and reduces the treatment time by approximately one and a half times.

One of the beneficial properties of the drug is its anti-inflammatory effect. The drug reduces the number of inflammatory mediators, relieves swelling, improves the transport of nutrients through interstitial fluid. The drug increases the elasticity of the connective tissue, which reduces the stagnation of blood and lymph in the area of ​​inflammation, reducing pain.

The tool is available in two types of dosage forms, which are assigned depending on the specific situation. What is the difference between Longidis disease and injections? According to instructions:

  1. Candles Longidase usually used when the causes of the formation of adhesions are gynecological in nature, they are often prescribed in urology. The course of treatment can be long, up to several months. They are applied vaginally or rectally. Due to the long-term effect of the drug is not used every day, doctors can prescribe it one candle in two to four days.
  2. Longidis powder is used as a solution for intramuscular or subcutaneous administration. Typically, such injections are prescribed locally by injecting the solution directly under the altered scar tissue, but it can also be used intramuscularly. The course is determined by the doctor and may include from 5 to 25 injections. For severe, long-lasting diseases after the main course, doctors may prescribe additional supportive therapy for 10–14 days. At the same time, like candles, the solution can be prick once every three to five days.

Colpitis triggered by trichomonads

If trichomonads are detected in the vaginal contents, the patient is prescribed suppositories containing metronidazole, which has an antimicrobial effect and is effective in combating trichomonads. This drugs Flagyl, Metrovagini, etc. Apply Metrovagin, Flagyle follows 1 supp. before bedtime.

Metronidazole derivatives are also prescribed - Trichopol, Klion D, Pitrid, Ginalgin, Flagyl, which are given 1 day per day for 10 days. Other candles are also widely used:

  • Gynomax (Tinidazole). Candles Gainomaks apply for 10 days.
  • McMiror - nystatin and nifturer are included in the composition, used for candidiasis, chlamydia, trichomoniasis, nonspecific vaginitis. Application course - 8 days.
  • Terzhinan, Mikozhinaks, Meratin-Kombi - every day for 1 pc. within 10 days.
  • Also appoint Trichomonacid, Trichocide for 10 days.
  • Neo-Penotran containing metronidazole and miconazole is used 2 times a day for two weeks.
  • Hexicon - 3 times a day, you need to apply Hexicon for 1-3 weeks.
  • Tinidazole is an analogue of the drug Hexicon. Apply Tinidazole similarly.
  • Evkalimin - according to the scheme prescribed by the doctor.

It should be noted that with trichomonas vaginitis, anti-inflammatory suppository therapy is carried out for three months, in cycles of 10 days. Start of application - immediately after menstruation.

What to use female candles for inflammation, which is better, the gynecologist will explain.

Use in children

It is forbidden to prescribe in children under 12 years of age, due to the lack of reliable clinical studies of the effect on this category of persons. Children 13–18 years of age are recommended similar treatment regimens to adults. Dosages also remain unchanged. Rectally or vaginally, before bedtime, 3000 IU of the drug is applied with an interval of 24-72 hours, in a cycle of 10 to 15 doses.

The interval depends on the system of organs in which the pathological process is observed. In severe cases of the disease, the doctor can adjust the course, increasing the intensity of the regimen.

Longidase for pregnancy and lactation

Women in the period

Pregnancy is a direct contraindication for treatment with longidase. Not recommended for breastfeeding, as there are no results of clinical studies on the effects on this group of women. However, it can be used in particular cases under strict medical supervision.

Treatment regimen

In gynecology, longididase is most often prescribed by doctors as suppositories, used rectally (injected into the rectum) or intravaginally (injected into the vagina). For children under 18 years of age, elderly people, patients with severe renal insufficiency, they are administered only rectally.

In other cases, the standard treatment regimen is as follows:

  • 1 candle every two days, at least 10 uses,
  • supportive therapy if necessary (the total course of treatment can be up to 20 applications),
  • repeated course is possible after 2-3 months.

With the use of rectal suppositories, you first need to clean the intestines, making an enema. Vaginal introduction is carried out for the night, in a prone position. During menstruation, the suppository is administered rectally so as not to interrupt the treatment.

Suppositories before use check: when you change the color, breaking the packaging it is better not to use them. If injections are prescribed by a doctor, you should know that they are perceived as painful by many patients. To avoid this, it is recommended to use procaine (0.25% or 0.5%) as a solution. Injections are administered either subcutaneously or intramuscularly.

Depending on the condition of the patient, his age, and concomitant pathologies, the attending physician selects an individual treatment regimen. Often, with endometriosis, 7-10 injections are required at a dosage of 3000 IU, one every 3-5 days.

Suppositories, as well as Longidase injections, can be used in the complex treatment of diseases, together with antibiotics, anti-inflammatory, hormonal and other drugs.

Dosage and indications

Longidol in gynecology is usually prescribed rectally or vaginally. To use each of the options attached instruction. For example, vaginal administration is prescribed as a key, however, in the presence of the menstrual cycle, suppositories with longidase are used rectally (as a result of which the therapeutic effect is reduced) by first emptying the intestine followed by a cleansing procedure. Usually they are recommended only after the end of the month.

This medicine is used for:

  • Cystitis
  • The presence of postoperative scars,
  • Urethritis
  • Spike of internal organs
  • Inflammatory processes of the prostate gland.

А Также чтобы понять для чего назначают препарат лонгидаза, отметим, что его терапевтическому действию нет ограничений в распространении только лишь на сферу гинекологии (лонгидаза при цистите, например). Joint treatment, surgery and dermatology - here the indications for use of this drug are quite appropriate.

As a rule, due to miscarriages, abortion and cleaning procedures, hormonal disruptions and pathologies, age-related changes, the endometrial tissues expand, preventing pregnancy. Often, as a manifestation of post-traumatic syndrome, chronic and inflammatory processes occur.

Candles "Longidase" localized eliminate these tissues, stop and stop foci of suppuration.

Specifically, in the gynecological sector, the drug is used:

  • Prevention and elimination of adhesive and cicatricial manifestations after operations or as a “post-traumatic”,
  • Treatment of chronic endometriosis,
  • Elimination of complete or partial compaction and fusion of uterine tissues (synechia).

As for the general positive effects. Due to two key components (azoxymere and bromide), which are present in the preparation, it contributes to:

  • Improved tissue permeability,
  • Strengthening trophic indicators,
  • Reduction of puffiness and resorption of hematomas,
  • Increase turgor (elasticity)
  • The disappearance of adhesions and contractures,
  • promotes mobility of joints
  • Suppression of connective tissue growth in scars.

Also, it is noted that "longidaza" binds heavy metals and, by suppressing toxins, promotes their elimination from the body. This tool has no toxic and carcinogenic prerequisites and is characterized by positive tolerability. According to reviews of patients, injections and suppositories "Longidase" do not entail consequences and are not catalysts for undesirable reactions.

Contraindications and possible complications in the form of side effects

Like any other drug, Longidase also has contraindications, along with side effects. Numerous studies have revealed that there are practically no bad effects, with the exception of individual allergic reactions to the components of the drug.

Candles can be used in a complex measure with other antibiotics and pain killers, while Longidase will only enhance the overall therapeutic effect.

Nevertheless, regardless of the information (which characterizes the drug as completely safe), there are a number of contraindications recommended for familiarization in order to avoid critical complications:

  • Acute stages of infectious diseases
  • Oncology,
  • Adrenal gland malfunction
  • Age less than 12 years
  • Pregnancy and lactation.

Basic recommendations for the use of the drug

Consider the basic points of the instructions for use:

  • As mentioned earlier, suppositories are designed for predominantly vaginal use, however, during menstruation, they are also administered rectally. The latter significantly reduces the efficiency, so it is worth waiting for the end of the cycle,
  • Use at bedtime, in a horizontal position (both vaginal and rectal suppositories). Before anal insertion, it is necessary to empty and clean the intestines with an enema,
  • Duration and dosage prescribed by the attending physician. It is not recommended to put these indicators on your own. Usually, one suppository (vaginally or rectally) is administered 1 time in three days,
  • Full course includes 10 candles. Depending on the statistics of improvements, you can continue prophylactic therapy (only after consulting with your doctor). Repeated course is appointed no earlier than 3 months.
  • In chronic renal failure and relatively recent bleeding, the use of this drug is not recommended. The maximum allowable measure is 1 suppository in 7 days.
  • If a clear allergic reaction occurs, you should immediately discontinue using Longidase.

Having understood the nuances of use, it is necessary to understand that the abuse of this drug also does not lead to "mild" consequences. Chills, a sharp decrease in blood pressure and an increase in body temperature: these are the general signs of an overdose. The period of elimination from the body is 2-3 days, this function is carried out by the kidneys.

Analogs "Longidase"

As mentioned in the article, the presented drug has copies, such as Lidaza and polyoxidonium, which have almost the same (as compared with the original) properties and indications for use. "Lidaza" is available only in the form of powder for the preparation of injections, drops or solution for inhalation.

Polyoxidonium is used both vaginally and rectally. The only, but significant difference is the absence in the list of the effects of preventive and therapeutic measures on adhesions and scars. Despite the fact that the analogue has fewer contraindications and a lower price, Longidase has a significant advantage in treating not only the causes of diseases, but also the elimination of their possible consequences.

Recommendations of specialists

Observing the treatment statistics of cystitis with this drug, the doctors noticed a decrease in pain effects, an increase in urination volume. The therapeutic effect persisted for six months. Throughout the course, excellent tolerability was noted along with minimal side effects. As a conclusion: “Longidase” is the recommended remedy for patients with various forms of cystitis, precisely for the purpose of abnormalities caused by the disease.

According to the results of completed courses of treatment of patients with adhesive processes, the tubular patency was revealed in the pelvis. Further observation with the diagnosis of infertility, marked pregnancy in 70% of cases.

Based on data based on monitoring the treatment with the use of Longidase candles, the drug showed a good effect with each of the presented diseases:

  • Cystitis,
  • Postoperative scars
  • Urethritis,
  • Spike of internal organs
  • Inflammatory processes of the prostate gland.

This kind of information was found on many medical forums and was included in the research results. Most of the positive reviews about the drug were associated with the treatment of gynecological diseases and, of course, the manifestation of a long-awaited pregnancy. Allergic reactions practically does not occur or they are insignificant.

It can be concluded: a well-developed algorithm for the use of the presented drug, along with accurate diagnostic procedures, gives a really good result, which can already be traced by the patient's treatment statistics. Thus, in conclusion, everything stated in the article, we note: despite the not quite attractive price, it is worth overpaying, but to get a real result, eliminating the risk of serious complications. Here is really the case when the goal justifies the means.

Composition and release form

There are two forms of drug release: suppositories for rectal or vaginal administration, powder for the preparation of injection solution.

  • The active substance of the drug - longidase with hyaluronidase activity.
  • Auxiliary component for the form of release candles is cocoa butter, for powder - mannitol.

Clinico-pharmacological group: a drug with proteolytic activity.

What helps candle-shaped Longidis?

The use of Longidase is shown in the complex treatment and monotherapy of diseases complicated by connective tissue hyperplasia, including in inflammatory processes:

  • Urology: chronic prostatitis, strictures of the ureters and urethra, Peyronie's disease, the initial stage of benign prostatic hyperplasia, interstitial cystitis, after surgery on the bladder, urethra, ureters for the prevention of scars and strictures.
  • Gynecology: chronic endomyometritis, intrauterine synechia, tubal-peritoneal infertility, prophylaxis and treatment of pelvic adhesions in chronic form of inflammatory pathologies of the internal genital organs, treatment and prevention of adhesions in the pelvis after artificial abortions, previous surgery on the pelvic organs and other gynecological manipulations.
  • Dermatovenereology: limited scleroderma, prevention of fibrous complications of infectious diseases transmitted through sexual contact.
  • Surgery: non-healing wounds, prevention and treatment of adhesions after operations on the abdominal organs.
  • Phthisiology and pulmonology: interstitial pneumonia, pulmonary fibrosis, tuberculosis (infiltrative, tuberculoma, cavernous and fibrous), fibrosing alveolitis, siderosis, pleurisy.

In addition, Longidase is prescribed to increase the bioavailability of diagnostic, medicinal drugs and antibacterial therapy in gynecology, urology, dermatology, pulmonology and surgery.


pharmachologic effect

Longididase is a macromolecular complex of the proteolytic enzyme hyaluronidase with a high molecular weight carrier. The drug has high hyaluronidase activity.

  • Longididase has an anti-edema, immunomodulatory, antioxidant, anti-inflammatory, chelating effect on the body.
  • With the use of the drug, trophicity and tissue permeability are markedly increased, hematomas dissolve, swelling decreases, and the level of elasticity of scars increases.
  • In the application of Longidase, the anti-fibrotic effect is noted.

The highest efficacy of the drug is observed when used in the early stages of diseases and pathological processes.

Side effects

In rare cases, hypersensitivity reactions to Longidase may occur.

Due to its composition, the suppositories Longidase can be equated to unique drugs that have virtually no analogues.

There are several drugs that are similar in composition, for example, Lidaza, but it is not a complete analogue, because it contains only one active substance - hyaluronidase, while in these candles there are two of them - hyaluronidase and azoximer bromide.

A drug such as Polyoxidonium may also, to some extent, serve as a substitute, but it is not used as a prevention of adhesive processes.

The average price of LONGIDAZ, candles in pharmacies (Moscow) is 1,600 rubles.

Pharmacy sales terms

The drug is approved for use as a means of OTC.

Good day! In January of this year, I underwent tests and hysterosalpingoscopy, I was diagnosed with inflammation of the ovaries while wearing the IUD. She found a good gynecologist, prescribed an antibiotic, sulfonamides, Longidase in candles and physiotherapy.

Candles inserted vaginally one candle every three days. The same was said to me about the adhesions, that when inflammation occurs, the pipes are compacted and the adhesions occur. It was treated, well, several months have passed, nothing has been bothering you.

I do not know who the drug Longidasa helped, but I personally have a negative experience with it. Or rather, my mom. She suffered a serious operation - peritonitis of the abdominal cavity. Naturally, there were large scars on the abdomen. Aesthetically, it is ugly. She went to a doctor, who prescribed this drug as an injection, without having performed any tests for susceptibility before prescribing. Naturally, the result was disgusting. At the injection site, swelling and soreness appeared almost immediately, and later an allergy came out, which we are still treating. Scars same nowhere. So doubtful some kind of drug.

I used longidisase only a year ago, while treating inflammation in the ovary. The doctor immediately warned that the most suitable for me were injections, so I had to put up with it. Pricked them with novocaine, because I am very afraid of all this. It was not very painful, tolerable. But there were no traces left and I notice now that no one in life will say that I have pricked injections. One course was enough for me, in principle I healed the inflammation and there was no more need for longidis. I am glad that after all this time nothing returned and there was no pain. It seems to me quite a good drug. A lasting effect is the main thing.

When the inflammation of the female helped longidaza well. Only with candles the doctor decided to treat me, and if there is no sense, then prescribe a complete and complex therapy. I was ready for the need to be treated for a long time and with different preparations, but in vain. Everything was limited to a course of 20 candle longidase. As I understood, this is the maximum rate, it stretched for 2.5 months somewhere. Candles are ordinary, easy to use, but the result is important.

The drug is very good! Many are satisfied with endometriosis. I have a doctor appointed every 3 days and so 10 days. But I put everyone and I have a strong irritation. It hurts while washing up. In general, I have a strong sensitivity. Because no one else in the reviews did not see this. Can someone report this? and so I will go to the doctor tomorrow (((

There have never been any complications and bad reactions, with longidaza everything went smoothly for me. The medicine is right for me. Well, this time. And secondly, I am grateful to the candles for the fact that the pain in the lower abdomen does not return, and I know that everything is in order with my body. I am among those who were helped by endometriosis. This is the most important thing for the medicine to help - in my opinion)

I also used candles two days later I tried to insert them twice into the moisture and I got an itch that it could still be an itch, what should I do?

Firstly, you would go to the doctor, secondly, read carefully all the contraindications in the instructions. Maybe you just have an elementary sensitivity to the composite component and that's it. It only surprises me that you inserted vaginally; on the contrary, I recommended rectally to me. After all, then there is no reference to the monthly and generally it is easier.

Girls who spoke with a good doctor, is it true that sparks can also form from laparoscopy ?? And then the meaning of such an operation ?? The gynecologist didn’t say anything like that to me, my colleague told me yesterday. Tell me, true or not, I do not want spikes again ((

After Lapar, I did not form, although the adhesions were like harnesses and the operation, as the doctor says, was not very easy. But I also inserted a longidacase course, 10 pieces, I think thanks to her everything is ok. I wouldn’t like to treat spikes again, I understand you

However, unfortunately (Lapara is needed when the adhesions are very much started and there is nothing else left, in other cases there is enough medicine. I inserted longidase candles from adhesions, they really became thinner, so the inflammation in the fallopian tube went away and the period became it is not so painful to go through, and if you need a 100 pro operation, then after it, longididase is also necessary as prevention.

It’s a little awkward to write here, count in the women's team, but I’m taking a chance) I’ve just been silent and then I was diagnosed with chronic prostatitis.) Longidaza means it also helps me in a woman’s way, I didn’t know. From the treatment of prostatitis - acts qualitatively. It works pathogenetically, so that not only the symptoms will remove. The most important thing is working with the central problem - fibrosis, from which all the main problems arise. So there is simply no other such drug theoretically, and I personally do not recommend spending money on soulless counterparts. For the miser pays twice. And here is the result - my remission is 8 months, and earlier every 3 months - relapse. Than not the result. All health.

Oh, read the stories here. Not easy for both girls and boys. And all the reasons - we are hammering on our health and setting priorities incorrectly. Recently treated endometriosis. Having read the Internet, my hair stood on end, so I realized that only a doctor (now I don’t read anything like that, I have nerves on the bank). They prescribed a longdaza injections, an anti-inflammatory, mud procedure that I just can not stand. I even bought a body, if only everything was warm there) It worked cool, after such a course it became less painful downstairs, and after a while the pain disappeared altogether. Pricked in the clinic with Novocain

Candidate Longidase: instructions for use in gynecology

The term hyperplasia means that in any organ or tissue in the body the number of cells has increased dramatically. It may have physiological causes, for example, with an increase in breast cells during pregnancy. However, it happens that such a growth develops as a disease, for example, in endometrial hyperplasia and requires special treatment.

One of the main ways to help cope with this ailment is medicines containing a special enzyme - hyaluronidase. In official medicine, such drugs have been used for over 40 years. One of them is Longidase.

Benefits of Longidase

The main advantage of the drugs Longidase, compared with drugs-analogues, such as Lidaz, for example, is its greater resistance to negative effects.

Such, for example, as the effects of aggressive substances that are formed in the focus of inflammation.

The hyaluronidase enzyme in this drug is protected by a special immunomodulator, known as Polyoxidonium.

In addition to greater stability, such a symbiosis can reduce the course of treatment with Longidase, as well as reduce the likelihood of various allergic reactions when it is used. Входящий в состав препарата иммуномодулятор помогает ему лучше воздействовать на воспаление, стимулирует местный иммунитет и помогает клеткам выводить токсины и свободные радикалы.

Лонгидаза является препаратом комплексного действия, помогающим не только бороться с гиперплазией ткани, но и с воспалением, которое часто является основной причиной её развития.

Perhaps the only drawback of Longidase is sensitivity to high temperatures requiring special storage conditions. Keep it at a temperature not higher than 15 C.

The tool is available in two types of dosage forms, which are assigned depending on the specific situation. What is the difference between Longidis disease and injections? According to instructions:

  1. Candles Longidase usually used when the causes of the formation of adhesions are gynecological in nature, they are often prescribed in urology. The course of treatment can be long, up to several months. They are applied vaginally or rectally. Due to the long-term effect of the drug is not used every day, doctors can prescribe it one candle in two to four days.
  2. Longidis powder is used as a solution for intramuscular or subcutaneous administration. Typically, such injections are prescribed locally by injecting the solution directly under the altered scar tissue, but it can also be used intramuscularly. The course is determined by the doctor and may include from 5 to 25 injections. For severe, long-lasting diseases after the main course, doctors may prescribe additional supportive therapy for 10–14 days. At the same time, like candles, the solution can be prick once every three to five days.

Candles and lyophilisate for Longidase Injection are a prescription drug. Only a doctor should prescribe them.

Application features

How exactly to carry out the treatment with Longidase, to assign you candles or injections is determined by the doctor, depending on the exact diagnosis, severity of the disease, age and other individual characteristics of the patient.

Courses can be from 5 to 25 days long, and the interval between taking the drug from 2 to 10 days. The dose of the drug is also determined individually. If necessary, treatment can be administered repeatedly, after a break of 2-3 months. Longidase can interact with other drugs, so it:

  • Enhances the effect of antiseptics, diuretic and antimicrobial agents.
  • Simultaneous use with estrogens, antihistamines, salicylates, cortisone and adenocorticotropic hormone reduces the activity of hyaluronidase.
  • Longididase can not be used simultaneously with drugs benzodiazepine series, furosemide and phenytoin.

Preparations with Longidase can be used both independently and in combination with other means prescribed by the doctor. Injections or suppositories with longidase are used in gynecology, urology and surgery. Instructions for use contains the following indications:

  1. Prevention and treatment of adhesions that may occur after surgery or as a result of a long, severe inflammatory process.
  2. With cystitis or prostatitis, usually in a chronic form, but sometimes in acute.
  3. In the treatment of infertility associated with obstruction of the fallopian tubes.
  4. For the prevention of adhesions after operations on the bladder, ureter or urethra.
  5. For the prevention or treatment of adhesions and scars after operations on the abdominal organs.
  6. In the treatment of long non-healing wounds or trophic ulcers.

In addition, Longidase is often used in cosmetology for the treatment of scars and scleroderma, in pulmonology, especially in complicated pneumonia and tuberculosis, as well as in orthopedics for contracture of the joints.

Longidase candles: reviews

The scope of the drug Longidase large. It is unlikely that he will cure the pathology on his own.

But in the complex, Longidase promotes healing and enhancing the effect with other medications. This is a drug with proteolytic activity, having in its composition conjugate hyaluronidase.

Contains anti-inflammatory, anti-edematous, immunomodulating, antioxidant properties.

What helps:

  • Longidase is used in general practice.. Helps increase the bioavailability of antibacterial agents
  • In surgical practice. Therapy of slowly non-healing wounds, prevention and treatment of postoperative adhesive processes, healing of hypertrophic scars,
  • In urological practice used as a treatment for cystitis, chronic prostatitis, prevention and treatment of ureteral strictures and urethra, elimination of narrowing of the urethra and ureters,
  • In gynecology treat tubal-peritoneal infertility, prevention and elimination of adhesions (including the period after a postponed abortion), chronic endomyometritis,
  • In dermatology and venereology: limited type scleroderma, fibrous infectious complications (transmitted through the genital tract), treatment of keloid scars (after injuries, burns, operations),
  • Phthisiology and pulmonology: therapy of siderosis, fibrosing alveolitis, pleurisy, pneumofibrosis, cavernous fibrous and infiltrative tuberculosis,
  • In orthopedics used for the treatment of arthrosis, hematomas, spondyloarthritis (ankylosing), contracture of the joints.

Candles Longidzas from adhesions and infertility

The causes of the formation of adhesions are:

  1. the presence of blood in the abdominal cavity
  2. inflammations
  3. surgical intervention,
  4. endometriosis (proliferation of the inner lining of the uterus).

When one of these causes is not treated for a long time, adhesions are formed. They are transparent films that connect the surface of an inflamed and healthy organ. Over time, a dense scar grows at the point of this compound.

Female diseases and infertility in most cause spikes. For this reason, the main reproductive organs are shifted, and the movement of sperm through the fallopian tube is difficult. During treatment, the adhesions dissolve, and the scarring process is reduced.

In gynecology usually used Longidis in the form of candles. Such use allows the active substance of the drug to penetrate as closely as possible into the tissue, where there is a focus of inflammation and the formation of adhesions.

The main recommendations for the use of candles Longidase in the treatment of adhesions and infertility:

  1. Candles are intended for rectal or vaginal administration. When menstruation candles need to be administered rectally, but the efficiency decreases. It is better to wait until the end of menstruation,
  2. Bedtime in position lying injected vaginal suppositories, and rectal need to enter only after emptying the intestine.
  3. Duration of treatment and the dosage is prescribed by the attending physician. In most cases, 1 candle is administered vaginally or rectally once every 3 days.
  4. Reception rate is 10 candles. May prescribe maintenance therapy after the first course. The secondary course is prescribed not earlier than 3 months after the completion of the previous one.
  5. With chronic renal failure and recent bleeding can not be applied more than 1 suppository in 7 days.
  6. If any reaction occurs hypersensitivity to Longidase; use must be stopped immediately.

Longidase for chronic endometritis

Endometritis - This is an inflammatory process of the inner layer of the uterus, it is often caused by various viruses or bacteria. With this course, the growth of the endometrium is disturbed, this leads to infertility.

Usually, chronic endometritis is found in sexually active patients.

High risk is observed in patients who:

  • have bacterial vaginosis,
  • are infected with genital herpes,
  • suffered an abortion
  • suffered a miscarriage
  • have uterine submucosa,
  • suffered a sexually transmitted disease
  • moved the scraping in order to diagnose,
  • used intrauterine device.

As a result of running endometritisspikes arise. In order to prevent the formation of adhesions and the destruction of existing ones, doctors prescribe Longidase. The course of treatment here is often long - 14-21 days. The remaining recommendations will be the same as in the treatment of infertility and adhesions.

The composition of the candles and who produces them

The drug in its composition contains conjugate hyaluronidase and high molecular weight water-soluble carrier (polyoxidonium), excipient (cocoa butter).

The producer of Longidase is NPO PetrovaxFarm LLC. This is the most modern pharmaceutical company in Russia. Production is located in Moscow and the Moscow region.

Candles Longidase In Gynecology

Repeated abortions, not fully treated infectious-inflammatory gynecological diseases, endocrine problems often lead to the fact that a woman cannot become pregnant for a long time.

For example, proliferation of connective tissue (adhesions) in the ovaries and fallopian tubes with a pathology such as endometriosis is usually the main cause of persistent infertility.

But Russian pharmaceutical scientists managed to create a drug, the clinical use of which proved high therapeutic efficacy in treating many female diseases. We are talking about immunomodulating suppositories Longidase.

This remedy has proteolytic enzymatic activity that allows a woman to restore fertility. Candles Longidase in gynecology are now very popular.

Longidase Properties

This vaginal and rectal drug is a compound (conjugate) of the proteolytic enzyme hyaluronidase with a high molecular weight biologically active carrier substance derived from polyoxidonium.

Thanks to this combination, the synthesis of the mediator of inflammation of interleukin-1 is suppressed, the resistance of hyaluronidase to destroying factors increases, and the connective tissue hyperplasia is eliminated - cicatricial, fibro-granulomatous and adhesions.

The spectrum of action of the drug extends only to areas that have undergone pathological changes, and Longidase does not damage healthy connective tissues, and has no carcinogenic or teratogenic effects.

Suppositories have a local anti-inflammatory, antioxidant, immunomodulatory effects, improving the movement of fluid in the intercellular space, reducing the swelling of connective tissue, destroying adhesions in the pelvic organs.

Longidis: instructions for use of candles and lyophilisate

Latin name: Longidaza
ATH code: V03AX
Active substance: Hyaluronidase and azoxymere bromide

Manufacturer: Petrovax Farm, Russia

Pharmacy release condition: On prescription

Longidase - a drug that exhibits proteolytic activity, while having anti-inflammatory, immunomodulatory and pronounced antioxidant properties.

Medicinal properties

Longidase is a macromolecular complex, the components of which are represented by a special enzyme hyaluronidase (proteolytic), as well as a high molecular weight carrier.

This drug shows pronounced hyaluronidase activity. Once in the body, it has anti-inflammatory and immunomodulatory effects.

In addition, the drug has antioxidant, anti-fibrotic and anti-edematous properties.

During the use of drugs, permeability of cells and tissues significantly increases, as a result of which there is a rapid resorption of existing hematomas, and swelling decreases. Along with this, the elasticity of the scar tissue increases.

Due to the glycolysis of glycosaminoglycans, there is a partial or complete elimination of adhesions, contractures disappear. This significantly increases the mobility of all joints.

The high effectiveness of the treatment is observed in the event that therapy is initiated in the early stages of the development of the disease or pathological changes.

Antioxidant properties of the drug are manifested due to the entry into the relationship of the active substance with iron ions, which activate the flow of free-radical processes. This effect contributes to an increase in collagen production, therefore drugs are used in cosmetology.

Under the action of drugs normalizes humoral immunity, this reduces the manifestation of an acute inflammatory process.

As Longidase 3000 does not impair the general condition of patients in the postoperative period, the drug can be used to prevent the formation of scar tissue and the occurrence of adhesions.

Longidase increases the bioavailability of other drugs, the drug has a positive effect on the effectiveness of local anesthetic agents.

The drug is low toxic, does not have a detrimental effect on both urinary and immune systems. In addition, does not show teratogenic and mutagenic effects.

After parenteral administration, the active component quickly enters the general circulation, its highest concentration is observed after 20-25 minutes. Longididase is fairly evenly distributed in cells and tissues, bioavailability is about 90%.

Hyaluronidase undergoes a process of hydrolysis, as a result of which it breaks down into low-molecular compounds, the metabolites are removed by the renal system. Full removal of metabolic products from the body is carried out after 4-5 days.

As a result of rectal administration, a rapid absorption of the active ingredient and its entry into the general circulation is observed. The highest rate in plasma is recorded after 1 hour. When using rectal or vaginal suppositories with longidase, bioavailability is 70%. The duration of the half-life of metabolites is 42-84 hours.

Longidase: detailed instructions for use

The price of candles: from 1761 to 1995 rubles. Price for lyophilisate: from 1645 to 2346 rub.

Injection Longidaze 3000 units. assigned to subcutaneous administration under the scar tissue or close to the affected area. The drug injections can be injected into the muscle, the standard course of drug treatment (3000 units) involves the introduction of from 5 to 25 injections.

In order to achieve better efficiency, the time interval between injections should be 3-10 days. The doctor may prescribe a second course of treatment with a solution for injection after 2-3 months.

A woman can choose: prick the drug further or take a break.

In case of a number of diseases, the medicine can be used for a long time; they are prescribed to give injections once a day in 10-14 days. How many injections need to be done in a particular case, check with your doctor.

If this drug is prescribed in injections (3000 units), it is worth diluting the contents of the vial or ampoule before use. For this, procaine 0.25% or 0.5% solution is used (the volume should be 1-2 ml). If the patient is intolerant of procaine, it can be replaced with the same amount of saline or specially prepared water for injection.

Longididase against wrinkles is also used, the pattern of application is determined individually.

Longidase to increase the bioavailability of drugs

If it is prescribed to use the solution to increase the bioavailability of other drugs, then a bottle of Longidase (3000 units) is diluted with 2 ml of saline. It will be necessary to administer the drug as well as the main drug, but in about 10-15 minutes. before the use of the main drug.

The introduction of the solvent into the ampoule should be as slow as possible, after which it will be necessary to sustain the solution for 2-3 minutes. and shake and use immediately for the intended purpose.

Cross-drug interactions

Since Longidase (suppositories and injection solution) is well tolerated, it can be used simultaneously with antibacterial agents, antiallergic, antifungal, and drugs with antiviral activity, bronchodilator drugs, cytostatic agents, GCS.

It is worth noting that Longidase (solution for injection) helps to increase the bioavailability of other drugs, increases the effectiveness of analgesics used.

Overdose

special instructions

With the development of an allergic reaction, the use of the drug should be canceled. If it is necessary to use Longidase in the form of suppositories against the background of exacerbation of the infectious process, it is necessary to take antimicrobial drugs in parallel.

There is no evidence of the effect of Longidase on the ability to drive a car or perform work requiring increased concentration of attention and psychomotor speed.

Vacation conditions

The drug belongs to the means of OTC.

Storage conditions

Store in a dry, protected from light, out of reach of children, at a temperature not exceeding 15 C, away from open flame. Shelf life 2 years. On the expiration of this period to use the drug is prohibited.

Manufacturer

Petrovax Farm, Russia

Candles Longidase price

The average cost of Longidase candles in pharmacies in Moscow is:

  • 10 candles per pack - 1800-2000 rubles.
  • 20 candles per pack - 3000-3200 rub.

  • Lidaz,
  • Ronidaza,
  • Lidaza-M

Candidate Longidase: instructions for use in gynecology

The term hyperplasia means that in any organ or tissue in the body the number of cells has increased dramatically. It may have physiological causes, for example, with an increase in breast cells during pregnancy. However, it happens that such a growth develops as a disease, for example, in endometrial hyperplasia and requires special treatment.

One of the main ways to help cope with this ailment is medicines containing a special enzyme - hyaluronidase. In official medicine, such drugs have been used for over 40 years. One of them is Longidase.

Mechanism of action

In any connective tissue contains hyaluronic acid, which is one of its most important components.

При возникновении воспаления или же после хирургического вмешательства часть тканей может замещаться соединительной.

Under certain conditions, these tissues suffer from hypoxia, they lack the necessary nutrients, including hyaluronic acid. As a result, a scar or spike is formed.

Hyaluronidase, affecting this acid, as the main substrate of connective tissue, accelerates the movement of fluid filling the space between the cells and improves the permeability of tissue barriers. In addition, it increases tissue elasticity, reduces swelling and helps the resorption of exudate formed during inflammation.

Benefits of Longidase

The main advantage of the drugs Longidase, compared with drugs-analogues, such as Lidaz, for example, is its greater resistance to negative effects.

Such, for example, as the effects of aggressive substances that are formed in the focus of inflammation.

The hyaluronidase enzyme in this drug is protected by a special immunomodulator, known as Polyoxidonium.

In addition to greater stability, such a symbiosis can reduce the course of treatment with Longidase, as well as reduce the likelihood of various allergic reactions when it is used. The immunomodulator, which is part of the preparation, helps it to better influence inflammation, stimulates local immunity and helps cells to remove toxins and free radicals.

Longidase is a complex action that helps not only to fight tissue hyperplasia, but also inflammation, which is often the main cause of its development.

Perhaps the only drawback of Longidase is sensitivity to high temperatures requiring special storage conditions. Keep it at a temperature not higher than 15 C.

The tool is available in two types of dosage forms, which are assigned depending on the specific situation. What is the difference between Longidis disease and injections? According to instructions:

  1. Candles Longidase usually used when the causes of the formation of adhesions are gynecological in nature, they are often prescribed in urology. The course of treatment can be long, up to several months. They are applied vaginally or rectally. Due to the long-term effect of the drug is not used every day, doctors can prescribe it one candle in two to four days.
  2. Longidis powder is used as a solution for intramuscular or subcutaneous administration. Typically, such injections are prescribed locally by injecting the solution directly under the altered scar tissue, but it can also be used intramuscularly. The course is determined by the doctor and may include from 5 to 25 injections. For severe, long-lasting diseases after the main course, doctors may prescribe additional supportive therapy for 10–14 days. At the same time, like candles, the solution can be prick once every three to five days.

Candles and lyophilisate for Longidase Injection are a prescription drug. Only a doctor should prescribe them.

Application features

How exactly to carry out the treatment with Longidase, to assign you candles or injections is determined by the doctor, depending on the exact diagnosis, severity of the disease, age and other individual characteristics of the patient.

Courses can be from 5 to 25 days long, and the interval between taking the drug from 2 to 10 days. The dose of the drug is also determined individually. If necessary, treatment can be administered repeatedly, after a break of 2-3 months. Longidase can interact with other drugs, so it:

  • Enhances the effect of antiseptics, diuretic and antimicrobial agents.
  • Simultaneous use with estrogens, antihistamines, salicylates, cortisone and adenocorticotropic hormone reduces the activity of hyaluronidase.
  • Longididase can not be used simultaneously with drugs benzodiazepine series, furosemide and phenytoin.

Preparations with Longidase can be used both independently and in combination with other means prescribed by the doctor. Injections or suppositories with longidase are used in gynecology, urology and surgery. Instructions for use contains the following indications:

  1. Prevention and treatment of adhesions that may occur after surgery or as a result of a long, severe inflammatory process.
  2. With cystitis or prostatitis, usually in a chronic form, but sometimes in acute.
  3. In the treatment of infertility associated with obstruction of the fallopian tubes.
  4. For the prevention of adhesions after operations on the bladder, ureter or urethra.
  5. For the prevention or treatment of adhesions and scars after operations on the abdominal organs.
  6. In the treatment of long non-healing wounds or trophic ulcers.

In addition, Longidase is often used in cosmetology for the treatment of scars and scleroderma, in pulmonology, especially in complicated pneumonia and tuberculosis, as well as in orthopedics for contracture of the joints.

Contraindications

Like most of the agents with enzymatic activity, Longidase is contraindicated during pregnancy, during breastfeeding and in children under the age of 12 for candles and up to 18 years for injections. However, these are not the only restrictions on its use. In addition, the drug in the candle can not be used:

  • With malignant neoplasms.
  • With increased sensitivity to substances, including auxiliary, which is part of the drug.
  • With increased sensitivity to the enzyme hyaluronidase.

As for the powder for the preparation of the solution, there are a few more contraindications. In addition to the general contraindications with candles, Longidase in this dosage form cannot be used:

  • In infectious diseases in the acute phase.
  • When bleeding, regardless of the reasons for their cause, especially for pulmonary.

If you have a chronic illness, be sure to tell your doctor before using Longidase.

Side effects

Negative effects of using Longidase are quite rare. The most frequent of these is pain at the injection site.

Sometimes there can be allergic reactions, itching, irritation and redness, mostly also near the injection site. As for candles, then their use is also possible the occurrence of allergies.

Usually all the unpleasant feelings pass within three days.

Cases of overdose for Candles Longidase are not described, but for the injection form in the instructions for use are the main symptoms.

If after the injection you feel a decrease in pressure, fever and dizziness, then the use of the drug should be stopped and as soon as possible to see a doctor.

Most of all Longidis is popular in gynecology, for example, doctors often prescribe candles for adhesions leading to infertility. Despite the fact that treatment with this drug is long and requires patience, it gives a good result and can help even with severe disease.

Longidase candles: reviews

The scope of the drug Longidase large. It is unlikely that he will cure the pathology on his own.

But in the complex, Longidase promotes healing and enhancing the effect with other medications. This is a drug with proteolytic activity, having in its composition conjugate hyaluronidase.

Contains anti-inflammatory, anti-edematous, immunomodulating, antioxidant properties.

What helps:

  • Longidase is used in general practice.. Helps increase the bioavailability of antibacterial agents
  • In surgical practice. Therapy of slowly non-healing wounds, prevention and treatment of postoperative adhesive processes, healing of hypertrophic scars,
  • In urological practice used as a treatment for cystitis, chronic prostatitis, prevention and treatment of ureteral strictures and urethra, elimination of narrowing of the urethra and ureters,
  • In gynecology treat tubal-peritoneal infertility, prevention and elimination of adhesions (including the period after a postponed abortion), chronic endomyometritis,
  • In dermatology and venereology: limited type scleroderma, fibrous infectious complications (transmitted through the genital tract), treatment of keloid scars (after injuries, burns, operations),
  • Phthisiology and pulmonology: therapy of siderosis, fibrosing alveolitis, pleurisy, pneumofibrosis, cavernous fibrous and infiltrative tuberculosis,
  • In orthopedics used for the treatment of arthrosis, hematomas, spondyloarthritis (ankylosing), contracture of the joints.

Candles Longidzas from adhesions and infertility

The causes of the formation of adhesions are:

  1. the presence of blood in the abdominal cavity
  2. inflammations
  3. surgical intervention,
  4. endometriosis (proliferation of the inner lining of the uterus).

When one of these causes is not treated for a long time, adhesions are formed. They are transparent films that connect the surface of an inflamed and healthy organ. Over time, a dense scar grows at the point of this compound.

Female diseases and infertility in most cause spikes. For this reason, the main reproductive organs are shifted, and the movement of sperm through the fallopian tube is difficult. During treatment, the adhesions dissolve, and the scarring process is reduced.

In gynecology usually used Longidis in the form of candles. Such use allows the active substance of the drug to penetrate as closely as possible into the tissue, where there is a focus of inflammation and the formation of adhesions.

The main recommendations for the use of candles Longidase in the treatment of adhesions and infertility:

  1. Candles are intended for rectal or vaginal administration. When menstruation candles need to be administered rectally, but the efficiency decreases. It is better to wait until the end of menstruation,
  2. Bedtime in position lying injected vaginal suppositories, and rectal need to enter only after emptying the intestine.
  3. Duration of treatment and the dosage is prescribed by the attending physician. In most cases, 1 candle is administered vaginally or rectally once every 3 days.
  4. Reception rate is 10 candles. May prescribe maintenance therapy after the first course. The secondary course is prescribed not earlier than 3 months after the completion of the previous one.
  5. With chronic renal failure and recent bleeding can not be applied more than 1 suppository in 7 days.
  6. If any reaction occurs hypersensitivity to Longidase; use must be stopped immediately.

Longidase for chronic endometritis

Endometritis - This is an inflammatory process of the inner layer of the uterus, it is often caused by various viruses or bacteria. With this course, the growth of the endometrium is disturbed, this leads to infertility.

Usually, chronic endometritis is found in sexually active patients.

High risk is observed in patients who:

  • have bacterial vaginosis,
  • are infected with genital herpes,
  • suffered an abortion
  • suffered a miscarriage
  • have uterine submucosa,
  • suffered a sexually transmitted disease
  • moved the scraping in order to diagnose,
  • used intrauterine device.

As a result of running endometritisspikes arise. In order to prevent the formation of adhesions and the destruction of existing ones, doctors prescribe Longidase. The course of treatment here is often long - 14-21 days. The remaining recommendations will be the same as in the treatment of infertility and adhesions.

The composition of the candles and who produces them

The drug in its composition contains conjugate hyaluronidase and high molecular weight water-soluble carrier (polyoxidonium), excipient (cocoa butter).

The producer of Longidase is NPO PetrovaxFarm LLC. This is the most modern pharmaceutical company in Russia. Production is located in Moscow and the Moscow region.

Contraindications

Longidase does not apply to:

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  • up to 12 years (no studies were conducted)
  • hypersensitivity to the components of the drug,
  • malignant tumors,
  • pregnancy (no studies),
  • renal failure
  • infectious diseases in acute form
  • lactation,
  • recent vitreous hemorrhage
  • pulmonary hemorrhage
  • hemoptysis,
  • It is not recommended to inject the drug in places where there is acute infectious inflammation.

Before use, the patient must inform the doctor about all the drugs used (the appointment of Longidase is allowed only with the simultaneous adoption of antimicrobial agents).

When using Longidase In the treatment of interstitial cystitis, doctors noted a decrease in pain, the cessation of nocturia, an increase in urination. The therapeutic effect was persistent and persisted for 6 months in most patients. Good tolerance throughout the treatment. Side effects occur occasionally.

Longidase may be recommended for use in patients with chronic or interstitial cystitis with the aim of correcting disorders that appear on the background of the disease.

As a result of the completed therapy of patients with adhesions in the pelvis marked tube patency. With further observation during the year in patients with tuboperitoneal infertility, the onset of pregnancy and childbirth were observed in 70% of cases.

This drug can be recommended for use in patients with adhesions in the pelvis, occurring against the background of inflammation of the uterus, endometriosis.

Candles Longidase showed a fairly good effect in the treatment of urethra, endometriosis, scar removal, as well as postoperative adhesions.

Such information was found in large numbers in various medical forums. Reviews of this drug most often positive.

Especially good reviews in the treatment of gynecological diseases, and in some there was a long-awaited pregnancy.

Allergic reactions practically do not complain.

A good result gives an accurate diagnosis and a properly developed scheme of drug use.

Candles Longidase In Gynecology

Repeated abortions, not fully treated infectious-inflammatory gynecological diseases, endocrine problems often lead to the fact that a woman cannot become pregnant for a long time.

For example, proliferation of connective tissue (adhesions) in the ovaries and fallopian tubes with a pathology such as endometriosis is usually the main cause of persistent infertility.

But Russian pharmaceutical scientists managed to create a drug, the clinical use of which proved high therapeutic efficacy in treating many female diseases. We are talking about immunomodulating suppositories Longidase.

This remedy has proteolytic enzymatic activity that allows a woman to restore fertility. Candles Longidase in gynecology are now very popular.

Longidase Properties

This vaginal and rectal drug is a compound (conjugate) of the proteolytic enzyme hyaluronidase with a high molecular weight biologically active carrier substance derived from polyoxidonium.

Thanks to this combination, the synthesis of the mediator of inflammation of interleukin-1 is suppressed, the resistance of hyaluronidase to destroying factors increases, and the connective tissue hyperplasia is eliminated - cicatricial, fibro-granulomatous and adhesions.

The spectrum of action of the drug extends only to areas that have undergone pathological changes, and Longidase does not damage healthy connective tissues, and has no carcinogenic or teratogenic effects.

Suppositories have a local anti-inflammatory, antioxidant, immunomodulatory effects, improving the movement of fluid in the intercellular space, reducing the swelling of connective tissue, destroying adhesions in the pelvic organs.

Indications for use

Gynecologists appoint Longidase suppositories for the complex therapy of connective tissue hyperplasia, the formation of adhesions that accompany such pathologies as chronic endomyometritis, ovarian cyst, endometriosis, intrauterine synechiae, and tube-peritoneal infertility. Also, these suppositories are used for prophylactic purposes to prevent the formation of adhesions after abortion (abortion) and operations (eg, laparoscopy) on the pelvic organs.

Mode of application

Longididase suppositories (3000 IU) are recommended to be inserted into the vagina - vaginally.

However, during the menstruation, the candles have to be used rectally (into the rectum), having previously emptied the intestines and made a cleansing enema.

При этом эффективность терапевтического действия снижается. Поэтому, если имеется такая возможность, предпочтительнее начинать лечение после окончания месячных.

Согласно инструкции, препарат вводят ежедневно, по одной свече на ночь, на протяжении 10 – 20 дней. The exact course of therapy is determined by the attending physician, depending on the duration and severity of the disease. Perhaps, at the end of treatment, maintenance therapy will be required: 1 suppository once a week for 3 to 4 months.

Contraindications

It should be noted that Longidase suppositories are well tolerated by patients, but it is necessary to take into account contraindications to their use.

It is not recommended to resort to the help of this remedy in case of pulmonary hemorrhages, the presence of malignant oncological tumors, acute renal failure, increased individual sensitivity to proteolytic enzyme preparations.

It is prohibited to use these suppositories for women during pregnancy. If there is a need for this medication during lactation, breastfeeding should be stopped.

Side effects and special instructions

A significant advantage of Longidase suppositories is the almost complete absence of side effects, although sometimes (in extremely rare cases) allergic reactions were still observed in some patients.

In addition, with the simultaneous use of suppositories with salicylates, estrogen-containing drugs, cortisone, antihistamines, the effectiveness of Longidase decreases.

And when combined with antibacterial drugs and anesthetics, the effect of the drug in question may be enhanced.

Suppositories Longidase are dispensed in pharmacies without a prescription, but without the examination of a physician their independent use is not recommended. According to clinical data, the use of candles Longidase in gynecology in most cases restores lost female fertility.

Many patients note that after a course of treatment with this drug, the ultrasound results show a normalization of the structure of the endometrium, a decrease in the severity of adhesive processes, and an improvement in the patency of the fallopian tubes.

All this contributes to the achievement of the main goal of therapeutic effects - the onset of a long-awaited pregnancy.

Longidis: instructions for use of candles and lyophilisate

Latin name: Longidaza
ATH code: V03AX
Active substance: Hyaluronidase and azoxymere bromide

Manufacturer: Petrovax Farm, Russia

Pharmacy release condition: On prescription

Longidase - a drug that exhibits proteolytic activity, while having anti-inflammatory, immunomodulatory and pronounced antioxidant properties.

Indications for use

Longidase is prescribed to adult patients and children of the older age group (from the age of 12) for monotherapy or complex treatment of ailments in which hyperplastic changes in the connective tissues are observed, including those that have developed in the process of inflammation:

  • Gynecology: the presence of adhesions in the pelvic organs during inflammatory processes occurring in the internal genital organs (chronic form) after surgery, syneses in the uterine space, infertility (tubo-peritoneal type), chronic endometritis
  • Urology: Peyronie's disease, chronic prostatitis, strictures in the urogenital system (urethra, ureters), cystitis (interstitial type), the initial phase of benign hyperplastic changes in the prostate gland, prevention of scarring of tissues and strictures after the operation on the urogenital system
  • Surgery: preventive measures and treatment of adhesions formed after abdominal surgery, non-healing wound surfaces
  • Phthisiology, pulmonology: pleurisy, pneumonia (interstitial type), siderosis, alveolitis (fibrosing form), pneumofibrosis, various forms of tuberculosis
  • Dermatovenereology: localized scleroderma, prevention of possible fibrotic changes after infection, which are transmitted through unprotected sex.

It is possible to use the drug in order to increase the bioavailability of the conducted antibiotic therapy for urological, gynecological, derma-inerologic, pulmonary ailments and after the implementation of surgery.

Candles contain a hyaluronidase conjugate with a water-soluble carrier called polyoxidonium (3000 IU), cocoa butter is additionally present.

Ampoules and vials contain longidase 3000 IU, mannitol is auxiliary components of the lyophilisate.

Medicinal properties

Longidase is a macromolecular complex, the components of which are represented by a special enzyme hyaluronidase (proteolytic), as well as a high molecular weight carrier.

This drug shows pronounced hyaluronidase activity. Once in the body, it has anti-inflammatory and immunomodulatory effects.

In addition, the drug has antioxidant, anti-fibrotic and anti-edematous properties.

During the use of drugs, permeability of cells and tissues significantly increases, as a result of which there is a rapid resorption of existing hematomas, and swelling decreases. Along with this, the elasticity of the scar tissue increases.

Due to the glycolysis of glycosaminoglycans, there is a partial or complete elimination of adhesions, contractures disappear. This significantly increases the mobility of all joints.

The high effectiveness of the treatment is observed in the event that therapy is initiated in the early stages of the development of the disease or pathological changes.

Antioxidant properties of the drug are manifested due to the entry into the relationship of the active substance with iron ions, which activate the flow of free-radical processes. This effect contributes to an increase in collagen production, therefore drugs are used in cosmetology.

Under the action of drugs normalizes humoral immunity, this reduces the manifestation of an acute inflammatory process.

As Longidase 3000 does not impair the general condition of patients in the postoperative period, the drug can be used to prevent the formation of scar tissue and the occurrence of adhesions.

Longidase increases the bioavailability of other drugs, the drug has a positive effect on the effectiveness of local anesthetic agents.

The drug is low toxic, does not have a detrimental effect on both urinary and immune systems. In addition, does not show teratogenic and mutagenic effects.

After parenteral administration, the active component quickly enters the general circulation, its highest concentration is observed after 20-25 minutes. Longididase is fairly evenly distributed in cells and tissues, bioavailability is about 90%.

Hyaluronidase undergoes a process of hydrolysis, as a result of which it breaks down into low-molecular compounds, the metabolites are removed by the renal system. Full removal of metabolic products from the body is carried out after 4-5 days.

As a result of rectal administration, a rapid absorption of the active ingredient and its entry into the general circulation is observed. The highest rate in plasma is recorded after 1 hour. When using rectal or vaginal suppositories with longidase, bioavailability is 70%. The duration of the half-life of metabolites is 42-84 hours.

Release form

Candles intended for rectal or vaginal use, of a yellowish tint, have a torpedo shape, placed in a ball. packing (inside 5 pieces). One pack contains 2 pack. Longidase candles with instructions.

The lyophilisate for the preparation of the solution (for injection), which is used for the purpose of im / p or c injection, is represented by a homogeneous crumbly mass of creamy-yellow swelling. Produced in ampoules or vials. Inside the carton pack there are 5 amp. or flac. with instructions.

Longidase: detailed instructions for use

The price of candles: from 1761 to 1995 rubles. Price for lyophilisate: from 1645 to 2346 rub.

Injection Longidaze 3000 units. assigned to subcutaneous administration under the scar tissue or close to the affected area. The drug injections can be injected into the muscle, the standard course of drug treatment (3000 units) involves the introduction of from 5 to 25 injections.

In order to achieve better efficiency, the time interval between injections should be 3-10 days. The doctor may prescribe a second course of treatment with a solution for injection after 2-3 months.

A woman can choose: prick the drug further or take a break.

In case of a number of diseases, the medicine can be used for a long time; they are prescribed to give injections once a day in 10-14 days. How many injections need to be done in a particular case, check with your doctor.

If this drug is prescribed in injections (3000 units), it is worth diluting the contents of the vial or ampoule before use. For this, procaine 0.25% or 0.5% solution is used (the volume should be 1-2 ml). If the patient is intolerant of procaine, it can be replaced with the same amount of saline or specially prepared water for injection.

Longididase against wrinkles is also used, the pattern of application is determined individually.

Longidase to increase the bioavailability of drugs

If it is prescribed to use the solution to increase the bioavailability of other drugs, then a bottle of Longidase (3000 units) is diluted with 2 ml of saline. It will be necessary to administer the drug as well as the main drug, but in about 10-15 minutes. before the use of the main drug.

The introduction of the solvent into the ampoule should be as slow as possible, after which it will be necessary to sustain the solution for 2-3 minutes. and shake and use immediately for the intended purpose.

Features of the use of candles

Before you apply Longidasa suppositum rectally, you must first clean the intestines. To get a good therapeutic effect with vaginal use, it is best to introduce a candle before going to bed at night, taking a horizontal position.

Application in urology: 1 soup. one time for 2 days. rectally, after the introduction of 10 candles, you will need to take a break, you can continue treatment after 2-3 days. To conduct one course of treatment will require 20 candles (dosage 3000 units).

Candles Longidase in gynecology: vaginal suppositories are administered one-time for 3 days. rectally or vaginally. A course of treatment for a woman involves the use of 10 candles.

Dermatovenerology: 3000 IU suppositories are administered once in 2-3 days. rectally One course will need 10-15 soup.

Surgery: 1 soup. once with a time interval of 2-4 days., administration is rectal. The treatment takes place with the use of 10 candles.

Pulmonology, phthisiology: 1 of sv. once with intervals of 3-5 days. (rectal administration). The treatment course - from 10 to 20 soup.

To get the best results in treatment, a repeated course of therapy may be prescribed, but not earlier than after 3 months. at the end of the previous one.

Persons with severe renal impairment or with previous bleeding may be prescribed no more than 1 med. in 7 days

In some cases, Lidaza therapy is indicated. What is better Lidaz or Longidaz, what is the difference between drugs, it is necessary to clarify with your doctor.

Use during pregnancy and HB

The drug Longidase is contraindicated during pregnancy.

If you need treatment during HB, it is necessary to complete lactation.

Contraindications

Medicines do not apply for:

  • Component Susceptibility
  • Availability of oncoprocesses
  • Pregnancy
  • Children age (up to 12 years old)

Precautionary measures

With special care, it is recommended to carry out treatment (suppositories or injections) in case of renal pathologies, pulmonary hemorrhage (even if it was observed much earlier than the started therapy).

You can not enter the drug in the area of ​​the infectious focus, tumor or active inflammatory process.

Cross-drug interactions

Since Longidase (suppositories and injection solution) is well tolerated, it can be used simultaneously with antibacterial agents, antiallergic, antifungal, and drugs with antiviral activity, bronchodilator drugs, cytostatic agents, GCS.

It is worth noting that Longidase (solution for injection) helps to increase the bioavailability of other drugs, increases the effectiveness of analgesics used.

Side effects

Local pains are possible, and allergic reactions may also occur. Cases of skin hyperemia, swelling at the injection site are not excluded. Observed manifestations disappear independently after 48-72 hours.

In some cases, the doctor may recommend switching to Lidasa, as there is often no difference in the therapeutic effects of their use.

Overdose

If you exceed the recommended dose (using the solution) are possible:

  • Chill occurrence
  • Lowering blood pressure
  • Severe dizziness
  • Change in body temperature (sharp increase).

During the application of candles overdose was not registered.

Storage conditions and shelf life

Storage of the drug involves the observance of a certain temperature (no more than 15 C). LS (candles, lyophilisate) can be stored for 2 years from the date of manufacture.

Price from 203 to 457 rubles.

This drug exhibits properties similar to Longidase, since the active ingredient is hyaluronidase. Lidaza application is shown to suspend arthrosis, cardiovascular diseases, neuritis, as well as for scars. Form release - lyophilisate.

Pros:

  • It is well tolerated.
  • Effective with a number of gynecological diseases
  • Can be applied externally.

Minuses:

  • Prescription
  • Not assigned to patients under 18 years of age.

How does the drug Longidase with infertility

Infertility is most often caused by adhesions occurring in the organs of the uterus. To eliminate adhesions and fight against infertility, a special gynecological agent is prescribed. Candles "Longidase" for infertility receive mostly positive reviews, because they allow you to quickly deal with endometritis and inflammation of the genital organs.

Longidase treatment

The drug is administered intracutaneously or subcutaneously near the site of injury, or under the scar, or intramuscularly. The dose, the course of treatment and the method of drug administration are determined by the doctor depending on the severity of the course of the disease and the age of the patient. Drug treatment can be repeated in 2-3 months.

For the prevention of the development of scars and adhesive disease (after surgery) Longidase is prescribed intramuscularly once every three days, 3000 IU each. The course of preventive treatment is 5 injections with an interval between them from 3 to 10 days.

  • treatment of adhesive processes in the small pelvis - 3000 IU 1 p. / 3-5 days intramuscularly, for the entire course - 10-15 injections,
  • treatment of tubal-peritoneal infertility - 3000 IU intramuscularly, a course of up to 15 injections, with the first five need to be done 1 p. / 3 days, and all subsequent ones - 1 p. / 5 days,
  • suppository treatment - 1 candle every two days, 10 injections per course.

  • treatment of chronic prostatitis - 3000 IU 1 p. / 5 days intramuscularly, a course - 10-15 injections,
  • treatment of interstitial cystitis - the dosage is the same, a course of up to 10 injections,
  • suppository treatment - 1 candle every other day - 10 administrations, then administration every 2-3 days (another 10 administrations). Total for the treatment of 20 candles.

  • treatment of adhesive disease - 3000 IU 1 p. / 3-5 days intramuscularly, a course - 10-15 injections,
  • treatment of poorly healing wounds - 1500-3000 IU 1 p. / 5 days intramuscularly, a course - 5-10 injections,
  • suppository treatment - 1 candle every two to three days, the course - 10 injections.

Dermatology and cosmetology:

  • Treatment of limited scleroderma - 3000-4500 IU 1 p. / 3-5 days intramuscularly, the course - up to 20 injections. Moreover, the doctor selects the course and dosage individually in each case. They depend on the location of the disease, its stage and clinical course.
  • Treatment of scars of various types and etiology - colloid, inverted, hypertrophic - 3000-4500 IU 1 p. / 3 days (subcutaneously or intratubular), a course of up to 15 injections. If necessary, the doctor may extend the course of treatment up to 25 injections with an interval of 1 p. / 5 days. If a large area of ​​skin is affected or the scar is old, then the treatment can take up to 20 injections when taking the drug for 1 p. / 5 days, while alternating the intramuscular and subcutaneous routes of administration.
  • Treatment with suppositories - the introduction of 1 p. / 2-3 days, only 10-15 injections per course.

Pulmonology and phthisiology:

  • treatment of pneumosclerosis - 3000 IU 1 p. / 5 days (intramuscular), the course - 10 injections,
  • treatment of fibrosing alveolitis - 3000 IU 1 p. / 5 days (intramuscular), course - 15 injections,
  • tuberculosis - 3000 IU intramuscularly 1 p. / 5 days, a course - up to 25 injections. The treatment of the disease is long, it depends on the severity of the course and can last up to a year with the introduction of 3000 IU of Longidase 1 p. / 10 days,
  • suppository treatment - introduction every 2-4 days, the course is 10-20 injections.

  • treatment of contracture of the joints - 3000 IU 1 p. / 3 days, (subcutaneously, near the site of injury), a course - 5-15 injections,
  • treatment of ankylosing spondyloarthritis and arthrosis - the dosage and injection site as described above, the course - up to 15 injections,
  • treatment of hematomas - the dosage is the same, the course - 5 injections.

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