The site provides background information. Adequate diagnosis and treatment of the disease are possible under the supervision of a conscientious physician.
Analgin belongs to the group of nonsteroidal anti-inflammatory drugs, derivatives of pyrozolone.
Analgin is used to relieve pain (marked analgesic effect). Most often it is used for tooth and headaches. Analgin also lowers body temperature, and therefore applies to various febrile conditions. Analgin also has anti-inflammatory properties (but this effect is mild).
The mechanism of action and distribution of the drug in the body
Analgin does not selectively block cyclooxygenase (an enzyme involved in the synthesis of prostaglandins). This leads to a decrease in the formation of prostaglandins, bradykinins and arachidonic acid. Prostaglandins are a group of physiologically active substances that are involved in the formation of inflammatory and painful processes.
Analgin also blocks pain impulses and increases heat transfer.
15-30 minutes after ingestion, the drug begins to act (when the therapeutic concentration of the drug in the blood is reached). The maximum concentration of analgin observed after 1-1.5 after administration. The approximate duration of the drug is 4-8 hours.
When ingested, metamizole sodium is well absorbed in the gastrointestinal tract (approximately 80-90%). A small part of analgin in contact with blood binds to blood proteins (albumin).
The remaining concentration of the drug is in unbound form. The active substance itself (metamizole sodium) has no pharmacological effect. The effect develops only after the conversion of metamizole sodium into a metabolite.
It occurs by hydrolyzing analgin in the liver. Analgin is converted to a metabolite (4 - aminoantipyrin), which has an analgesic and antipyretic effect.
Having the desired effect, the metabolite is excreted in the urine. Also, the drug is able to penetrate the placenta and pass into breast milk.
Features of the use of metamizole sodium
Analgin should be under the strict supervision of a physician, especially if patients take chemotherapy (used to treat malignant tumors).
In patients with bronchial asthma, taking analgin increases the risk of allergic reactions.
Analgin should not be used to relieve acute abdominal pain.
When is analgin prescribed?
- algomenorrhea (severe pain during menstruation)
- postoperative pain
- migraine pain
- renal and hepatic colic (with antispasmodics)
- feverish states
- rheumatoid arthritis
How to apply metamizole sodium?
First you need to choose the most convenient form of release.
Tablets, for example, are the easiest to use, as this does not require any special skills.
The main advantage of injections is to have the effect most quickly, but they imply the need for certain nursing skills.
Candles are usually used in children. This is very convenient, since it is not necessary to force the child to drink a pill or persuade him to give an injection.
Composition and forms of release
What is the active ingredient "Analgin"?
This drug is made in several dosage forms - tablets, injection solutions and rectal suppositories.
The composition of the drug in the form of tablets - metamizole sodium, additional substances - powdered sugar, talc, calcium stearate, potato starch.
The composition of injection solutions contains the main substance - metamizole sodium and auxiliary - injection water.
The price of "Analgin" in ampoules is quite acceptable.
The main element, metamizole sodium, and the additional substance in the form of solid fat are included in the rectal suppositories.
Tablets are packaged in blisters of 10 pieces, one each or two blisters in cartons. Injection solutions are produced in glass ampoules of 2 ml or 1 ml, which are packaged in cardboard boxes. Rectal suppositories - in dosages of 250 and 100 mg, 10 pieces in a carton.
What pills "Analgin" help? We will understand.
The medicinal product represents the pharmacological group of antipyretic analgesics from the category of NSAID drugs - pyrazolones.
Pharmacokinetics and pharmacodynamics
The principle of action of metamizol is similar to the mechanism of action of other NSAIDs. The basic substance indiscriminately inhibits the activity of COX enzymes that are involved in the synthesis of prostanoids, reduces the formation of some Pg, endoperexides, bradykinins and free radicals, and contributes to the inhibition of lipid peroxidation.
The effect of this drug can not be considered absolute, as in cases with other NSAIDs, because it can be blocked in the process of stimulation of receptors that provoke inflammation.
The drug interferes with carrying out exteroceptive and proprioceptive impulses along the beams of Gaulle and Burdach, increases the threshold of excitability of the center of pain sensitivity in the thalamus region and the intensity of heat transfer.
If we talk about the anti-inflammatory activity of metamizol as the main element of this medical device, it is slightly expressed, as a result of which the drug has almost no effect on water and electrolyte metabolism (retention of Na + ions and water), mucous membranes of the digestive canals.
Very effective "Analgin" for menstruation.
In addition to relief of pain, the drug helps to reduce the temperature during the development of hyperthermia and has a slight antispasmodic effect (for example, relieves spasms of smooth muscles of the urinary and biliary tracts).
The effect of the use of Metamizole occurs in approximately 20-50 minutes, and its maximum severity is observed after two hours.
Not everyone knows from what tablets "Analgin" apply.
The results of the analysis of the effectiveness of the use of an agent such as Aspirin and Analgin from an elevated temperature have shown that the antipyretic activity of the main substance Analgin is lower than that of Aspirin, however, it is significantly higher if we compare this drug with such drugs. as Paracetamol and Ibuprofen. Analgesic efficacy with the use of Metamizole is also more pronounced than with these drugs.
This pharmaceutical substance is rapidly absorbed from the digestive system. In the intestinal cavity, it undergoes hydrolysis to form a therapeutically active metabolite. In unchanged form, metamizole sodium is not observed in the blood (small concentrations of the substance are noted in the plasma only when the intramuscular injections of this drug are made). The metabolite binds to plasma proteins by about 50-65%.
Metamizole undergoes a process of metabolism in the liver, and its elimination is carried out through the kidneys. The half-life is 1-4 hours. Substance is able to penetrate into breast milk.
Shelf life "Analgin" must be respected.
Indications for use
The main effect of the main substance is anesthetic, which makes it possible to use this medicine to relieve pain syndrome of various etiologies. The scope of the medical device:
- headache, menstrual and toothache (“Analgin” is irreplaceable for menstruation),
- pain associated with pathological conditions such as ischialgia, neuralgia, myalgia, colic (intestinal, hepatic or renal),
- pain in myocardial infarction, arterial thrombosis,
- pain in an aortic dissecting aneurysm,
- pain of various inflammatory processes (lumbago, myocarditis, pneumonia, myocarditis, pleurisy, etc.),
- pain while getting burns and injuries
- pain with decompression sickness, the formation of tumors,
- pain during perforation of the esophagus, orchitis, shingles, pancreatitis, priapism, peritonitis, post-transfusion complications.
Is it possible to give "Analgin" to children? This is a frequent question.
Other indications for use of the “Analgin” medical product may be:
- fever syndrome with insect bites and urological, infectious or purulent diseases at the acute stage.
The use of this drug is resorted to when other therapeutic measures do not help in order to alleviate intense pain (acute or chronic).
The drug "Analgin" in ampoules is prescribed in exceptional situations: when enteral use of the drug is not possible, to eliminate very strong postoperative pain, in cases when it is necessary to quickly bring the temperature down. Sometimes (quite rarely) injections are used in the treatment of osteochondrosis and arthritis.
When pain syndrome of moderate intensity (for example, cephalgia) is enough, as a rule, take a pill.
What is the price of "Analgin" in ampoules?
This drug costs about 70 rubles in ampoules. The price of tablets is 30-50 rubles. It depends on the region and the pharmacy network.
This medicinal form of medicine is intended for the treatment of children older than one year. In children, it is advisable to use this medication in case of severe tooth and headache, pain when getting burns, as well as in myositis and neuralgia. Also very effective suppositories for pain in the postoperative period.
The shelf life of "Analgin" depends on the form of release.
Contraindications to use
The instructions for use of this pharmacological agent describe the following pathological and natural conditions in which the intake of this medication is contraindicated:
- high sensitivity to metamizole, as well as to pyrozalidines and pyrazolone derivatives (the drug is not prescribed, including for people who have experienced agranulocytosis during the use of these drugs), as well as to additional components of tablets,
- a history of bronchial aspirin asthma,
- intolerance to NSAIDs or simple analgesics,
- bone marrow suppression or pathological condition of the hematopoietic system,
- hereditary or congenital form of hemolytic anemia, which is caused by a deficiency of cytosolic enzymes,
- intermittent acute porphyria,
- hypotension or unstable hemodynamics,
- suspected surgical pathology in acute.
In pediatric practice, this drug in tablet form is used only from the age of ten, in the form of suppositories - in children after one year.
Intramuscularly, this medicine can not be prescribed to children up to three months, as well as weighing up to 5 kg. Contraindications for intravenous injections of "Analgin" is the age from 3 to 12 months.
Adverse reactions from the use of the drug "Analgin" appear as:
- lowering blood pressure
- hypersensitivity symptoms
- interstitial nephritis.
Pill dosage regimen
When used in tablets, dosages are selected depending on the intensity of the pain syndrome and the individual reactions of the body to therapeutic measures. The most optimal is the use of the minimum dosage that controls fever and pain.
Tablets are swallowed whole and washed down with liquid. For an adult weighing more than 55 kg, a single dose of the drug is 1-2 tablets. If a single dose is not enough, the maximum single dose (two tablets) is allowed to be taken three times during the day. Safe limit daily dosage - 8 tablets.
For toothache, medication begins with half a pill. If this dose did not help eliminate the pain, you can take the remaining half.
The mode of application and dosing of solutions for injection
The dosage of "Analgin" in ampoules is selected depending on the severity of fever, pain, age and weight of the patient, as well as individual reactions to treatment. It should be minimal, but at the same time allowing to remove manifestations of pain and other pathological conditions.
A single dosage of "Analgin" on the temperature for patients with a weight of more than 55 kg ranges from 500 mg to 1 g. This means that for one injection you need to take 1-2 ml of solution. If necessary, a single dose is increased to 5 ml. The permissible limit of the daily dosage of the injection "Analgin" corresponds to 5 g.
The drug is administered intravenously or intramuscularly only in cases where it is necessary to quickly achieve the desired effect. With parenteral administration, the risk of anaphylactoid reactions is higher than with oral administration or the use of suppositories.
In children under one year, the solution is allowed only for intramuscular injection. In this case, the temperature of this solution should correspond to the maximum body temperature.
As a solvent, you can use Ringer's complex lactate solution, glucose solution or sodium chloride solution.
Due to the alleged incompatibility, the medical agent “Analgin” in the form of a solution is not recommended for use in the general system for infusions or in a common syringe with other medicines.
The difference between the drug "Analgin-quinine" from the usual "Analgin" is that it contains quinine in addition to the main substance, thanks to which this medicine has a pronounced effect against Plasmodium unicellular parasites, which suppress the development of the malarial plasmodium. In addition, it has antipyretic and analgesic properties.
Quinine suppresses the center of thermoregulation, which is located in the hypothalamus, and in case of its use in high doses, the auditory and visual zones of the hemispheres.
The drug is prescribed for pain of various origins, for inflammatory pathologies, and also (in combination with antispasmodics) for renal and biliary colic.
Often this drug is used in gynecology, after abortion and childbirth.
The period of validity of the drug "Analgin"
After taking the medicine begins to act in about twenty to fifty minutes. It takes two hours to achieve the highest effect. The effectiveness of the means for injection administration develops much faster.
In older people, as well as in patients with reduced renal function, the medicine is used in lower dosages, since the metabolites of the main substance are eliminated more slowly than in young patients, as well as in those whose kidneys are functioning normally.
With reduced hepatic or renal function, high doses should be avoided. Without reducing the dosage, only short-term use of this drug is possible.
Patients receiving this medicine for a long time should have blood tests to control their white blood cell count.
Blood pressure while taking the medication
The instructions indicate that taking metamizol is associated with the risk of developing hypotension, as well as sensitivity reactions. In this regard, the feasibility of using this pharmacological agent in a dose above 1 g requires an assessment of the risk / benefit ratio.
The solution is injected under the supervision of a specialist in the prone position.
To prevent a decrease in pressure and ensure the possibility of stopping the introduction of the solution in case of anaphylactic reactions, “Analgin” should be injected intravenously as slowly as possible.
To reduce the adverse effect of the drug on the mucous membranes of the stomach, it is recommended to replace “Analgin” with the medicine “Analgin Ultra”. These tablets are less irritating to the digestive organs.
Use of the mix "Analgin" with "Dimedrol"
The combination of these drugs is used only in critical situations when it is necessary to bring down the high temperature (including children in infancy).
One of the effective remedies for hyperthermia, with which other drugs cannot cope, is the injection of “triad”, which consists of “Dimedrol”, “Papaverine” and “Analgin”. After intramuscular injection of such a mixture, the temperature decreases within fifteen minutes.
The dosage of 50% solution of the drug "Analgin" for the manufacture of a lytic mixture is determined at the rate of 10 mg / kg.
Symptoms of overdose
An overdose of the medical agent "Analgin" can manifest itself in the form of the following conditions:
- marked reduction in pressure
- noise in ears,
- excessive weakness
- disturbance of consciousness, delirium,
- convulsive syndrome.
Not excluded the risk of hemorrhagic syndromes, liver or kidney failure, acute agranulocytosis.
Deadly dosage in pills - from 15 to 20 grams.
Treatment of overdose involves immediate measures: gastric lavage, induction of vomiting, use of enterosorbents and saline laxatives, alkalization of urine, forced diuresis. Subsequently, therapy is aimed at the regulation of impaired functions of organs.
Shelf life "Analgin" specified in the instructions.
The effect of this pharmacologic drug is enhanced by substances such as caffeine, H2-antihistamines, barbiturates. The slowing down of inactivation of the main substance is promoted by Propranolol.
The use of the drug in combination with sarkolizinom and tiamazol can cause leukopenia. When taken simultaneously with sedatives and tranquilizers, the analgesic effect of metamizol is enhanced.
Simultaneous use with NSAIDs or antipyretic agents can provoke a mutual increase in toxicity, and use with phenothiazine derivatives - an increase in temperature.
In combination with myelotoxic drugs, the hematotoxicity of the drug “Analgin” increases, which enhances the activity of hypoglycemic drugs and indirect anticoagulants. In addition, it reduces the concentration of cyclosporine.
Pharmacological action Analgin
The active ingredient of Analgin is metamizole sodium, a chemical compound from the pyrazolone group, a nonsteroidal anti-inflammatory agent (NSAID). Reduces the production of prostaglandins - specific inflammatory mediators (anti-inflammatory effect), increases the body's heat transfer (antipyretic effect), increases the threshold of sensitivity of the painful centers of the thalamus and creates obstacles for the conduction of pain impulses in the central nervous system (central anesthetic effect). The anti-inflammatory effect is less pronounced than that of other NSAIDs, and the antipyretic is stronger, metamizole sodium is the most powerful antipyretic of this group. Practically does not irritate the mucous membrane of the digestive tract and does not lead to disruption of water-salt metabolism. It has antispasmodic activity against the smooth muscles of the biliary and urinary tract.
Analgin begins to act within 20-30 minutes after ingestion, reaching a peak in 1-2 hours. It is easily absorbed in the gastrointestinal tract, dissolves well in almost all medical solutions, which makes it convenient to use both orally and parenterally.
The drug is available in the form of powder, tablets, solution for injection and suppositories.
Tablets for adults: 1 tablet contains 500 mg of metamizole sodium, 10 pcs. in a blister.
Analgin children are produced in the form of tablets with the content of the active substance 50, 100 and 150 mg, as well as in the form of suppositories - 1 suppository contains 10 mg of metamizole sodium.
Solution for injection: 1 ml contains 500 mg (50% solution) or 250 mg (25% solution) of metamizole sodium, produced in ampoules of 1 or 2 ml, 10 pcs. in a carton package, instructions for using Analgin are enclosed in each package.
Side Effects of Analgin
When used according to indications and selection of dosage in accordance with the instructions for use Analgin is well tolerated by patients, both adults and children, and rarely causes unwanted effects.
Prolonged use of Analgin can cause impaired blood formation, especially granulocytes. In some countries, the drug was banned because it aroused suspicions that its use leads to agranulocytosis, a blood disease that directly threatens life. However, after a series of studies it was found that the danger is significantly overvalued. Currently, it is estimated as extremely low, however, this possibility is not excluded.
Also, instructions for use of Analgin indicate the possibility of allergic reactions with individual intolerance to the drug, to a greater extent it relates to the drug, administered parenterally (intravenously).
Contraindications to use of Analgin
In accordance with the instructions for use Analgin is contraindicated in the following cases:
- Individual intolerance to metamizole sodium and other pyrazolone derivatives,
- Blood disorders and blood diseases,
- The deficiency of the enzyme glucose-6-phosphate dehydrogenase (hereditary hemolytic anemia),
- Aspirin asthma in history
- Insufficiency of the liver and / or kidneys,
- The first trimester and the last 6 weeks of pregnancy
- Breastfeeding period (Analgin penetrates into breast milk).
Analgin children prescribed for indications not earlier than 3 months of age.
With caution, the drug is used in patients with kidney disease in history, chronic alcoholism, low blood pressure (systolic blood pressure below 100 mmHg), with multiple injuries, cardiogenic shock and other situations characterized by unstable blood circulation.
Instructions for use Analgin
Analgin can be administered in the form of tablets, suppositories, intramuscular or intravenous injections. Subcutaneous injections are unacceptable because of the high risk of complications associated with the irritation of superficial tissues, for the same reason for intramuscular injections it is necessary to choose a long needle.
The following dosage is recommended for ingestion:
Adults - 250-500 mg 2-3 times a day to relieve pain or hyperthermic syndrome,
Analgin children in the form of tablets prescribed in a dose of 5-10 mg of the drug per 1 kg of body weight per day, divided into 3-4 doses.
Tablets should be taken after meals with plenty of clean, non-carbonated water.
In the form of analgin suppositories, children are administered rectally in the following dosage:
From 6 months to 1 year - ½ suppositories per day,
From 1 year to 3 years - 1 suppository per day,
From 4 to 7 years old - 2 suppositories per day.
After the administration of the suppository with Analgin, children need to lie down for half an hour.
Parenteral drug is administered in the following dosage:
Adults 1-2 ml of 50% solution of Analgin 2-3 times a day,
Analgin for children - at the rate of 0.1-0.2 ml of a 50% solution or 0.2-0.4 ml of a 25% solution for every 10 kg of body weight.
The maximum permissible dose for adults is 1000 mg - single, 2000 mg - daily.
Attention! It is unacceptable to use Analgin in case of acute pain of unexplained nature before the doctor examines the patient!
Prolonged use of the drug requires periodic monitoring of blood leukocyte count.
In some cases, the introduction of Analgin can stain urine red, which is not a sign of negative phenomena, is associated with the release of the intermediate metabolic metamizole sodium and does not require discontinuation of the drug.
This tool is incompatible with the use of alcohol.
It is unacceptable to mix in one syringe Analgin with other drugs.
It interacts with other medicinal substances, changing them and its therapeutic activity, therefore, when taking other drugs, it is necessary to inform the attending physician about the use of Analgin.
What is Analgin
Analgin belongs to the group of non-narcotic analgesic drugs. The drug helps, if desired, to achieve an analgesic, antipyretic, antispasmodic effect. The international name is Metamizole sodium. Many analogues have been created on the basis of metamizole sodium. The most famous of them are:
Metamizole sodium is part of the complex preparations, the active ingredients of which enhance the therapeutic effect of each other. Complex drugs have more pronounced therapeutic properties. The most popular ones are:
- Akabel (metamizole sodium and bevonium),
- Remidon (metamizole sodium, paracetamol, caffeine),
- Anapirin (metamizole sodium, aminophenazole, caffeine).
Akabel has enhanced antispasmodic properties. Can be used for cramping pain during menstruation.
Remidon has a pronounced antipyretic effect. It is used for aching and pulling pain. Caffeine, which is part of the drug, stimulates the nervous system, increases efficiency, improves mood.
Anapirin has a combined effect. Equally relieves pain, relieves spasm, and normalizes body temperature.
The mechanism of action of the drug
The drug has a high bioavailability, penetrates well into the tissues and quickly has a therapeutic effect. The drug belongs to the substance of rapid response. The therapeutic effect begins within 20 minutes after taking the drug.
The first action of Analgin is to slow down the pain impulse along the nerve fibers. This is due to the elimination of pain.
Getting into the center of pain, metamizole sodium inhibits the production of prostaglandins, which are responsible for the increase in body temperature during inflammation. The drug is sensitive to receptors of the smooth muscles of the genital organs. It stabilizes the cell membrane of smooth muscles, providing antipyretic and antispasmodic action.
By strengthening the cell membrane, the drug thereby retains sodium and water in the body. The provoked organism can cause swelling.
If the pain in varying degrees, the whole month, then you need to consult a doctor to clarify the diagnosis and correction of treatment.
Contraindications and side effects
Analgin disrupts the production of leukocytes in the red bone marrow, thereby reducing their content in the blood. Low white blood cell count does not allow the body to sufficiently deal with infectious environmental factors. The drug violates blood clotting. With prolonged use leads to bleeding.
For women with impaired renal function and liver, Analgin aggravates the course of the underlying disease, and may cause renal and hepatic failure.
Contraindications to the drug are:
- blood diseases
- hereditary hemolytic anemia,
- kidney disease in the stage of decompensation,
- alcohol intake
- bronchial asthma,
- allergy to the drug in history.
Do not take the drug for acute pain to establish the cause. Analgin will erase the picture of the disease and can lead to a serious condition.
Side effects are observed with prolonged and unsystematic use of the drug. The most common symptoms are:
- allergic reaction,
- renal failure
- lowering blood pressure.
Women suffering from seasonal pollinosis should use the drug with caution. Hypersensitivity reaction possible.
Analgin displaces blood sugar reducing agents from the blood. Therefore, their combined use requires strict glycemic control.
The drug can not be used with a glass of alcohol. Analgin enhances the toxic effect of alcohols on the liver, violates its function. Sedative drugs potentiate the effect of Analgin on the body. Therefore, an increase in daily intake of the drug can lead to side effects. Before using the medication, you should consult with your doctor.
Analgin: prices in online pharmacies
Analgin tab. 500mg n10
Analgin tab. 500mg n10
Analgin 500 mg n10 tabl
Analgin tab. 0.5 g №20
Analgin avexima tab. 500mg n10
Analgin solution 500 mg / ml 2 ml 10 pcs.
Analgin tab. 500mg n20
Analgin solution 500 mg / ml 2 ml 10 pcs.
Analgin injection 50% 2 ml n10 amp
Analgin tab. 500mg n20
Analgin solution 500 mg / ml 2 ml 10 pcs.
Analgin 500 mg № 20 tabl renneval
Analgin avexima tab. 500mg n20
Analgin solution for in / in and in / m intro. 500mg / ml 2ml №10
Analgin solution 50% 2 ml 10 pcs.
Analgin ExtraCap capsules 500 mg 2 ml 10 pcs.
Analgin rr d / in 50% 2 ml No. 10 grotex
Information about the drug is generalized, is provided for informational purposes and does not replace the official instructions. Self-treatment is dangerous for health!
The rarest disease is Kourou's disease. Only representatives of the Fur tribe in New Guinea are ill. The patient dies of laughter. It is believed that the cause of the disease is eating the human brain.
According to statistics, on Mondays, the risk of back injuries is increased by 25%, and the risk of a heart attack - by 33%. Be careful.
During operation, our brain spends an amount of energy equal to a 10-watt light bulb. So the image of a bulb above the head at the moment of the emergence of an interesting thought is not so far from the truth.
Human bones are four times stronger than concrete.
In order to say even the shortest and simplest words, we will use 72 muscles.
A person taking antidepressants will in most cases suffer from depression again. If a person copes with depression by his own strength, he has every chance to forget about this state forever.
According to many scientists, vitamin complexes are practically useless for humans.
Cough medicine "Terpinkod" is one of the top sellers, not at all because of its medicinal properties.
With regular visits to the tanning bed, the chance of getting skin cancer increases by 60%.
When lovers kiss, each of them loses 6.4 calories per minute, but at the same time they exchange almost 300 types of different bacteria.
Even if a man’s heart does not beat, he can still live for a long period of time, as the Norwegian fisherman Jan Revsdal showed us. His "motor" stopped at 4 o'clock after the fisherman got lost and fell asleep in the snow.
The weight of the human brain is about 2% of the entire body mass, but it consumes about 20% of the oxygen entering the blood. This fact makes the human brain extremely susceptible to damage caused by lack of oxygen.
People who are accustomed to having breakfast regularly are much less likely to be obese.
Everyone has not only unique fingerprints, but also a tongue.
The average life expectancy of left-handers is less than right-handers.
To date, we do not reliably know the exact number of people infected with human papillomavirus. Nevertheless, we know that every seventh person is ill.
Dosing and Administration
Tablets are taken after a meal, drinking plenty of water. Duration of application - no longer than 5 days.
The dosage is determined by the intensity of the pain syndrome and the body's response to taking Analgin. Below are the average recommended doses of the drug.
For adults and children over 14 years. The drug is taken at 0.5 g to 3 times per day. The maximum permissible single dosage is 1 g (2 tablets), the maximum daily dosage should not exceed 4 g.
For children from 10 to 14 years old (weighing from 32 kg to 53 kg). The recommended single dose of Analgin is 0.5 g. The maximum daily dose is not more than 2 g of metamizole sodium.
The undesirable side effects of analgin include:
- lowering blood pressure
- skin rash,
- agranulocytosis (the risk of agranulocytosis increases with the continuous use of Analgin for 7 days)
- acute deterioration of renal function, leading to the development of proteinuria, anuria, oligonuria or acute renal failure,
- development of hepatitis.
In case of overdose, dyspnea, palpitations, nausea and vomiting, tinnitus, impaired consciousness, and convulsive syndrome may occur. Acute renal / hepatic failure, agranulocytosis may develop.
To eliminate the symptoms of overdose, artificial induction of vomiting, gastric lavage, and intake of saline laxatives and sorbents is necessary. Symptomatic treatment is carried out to restore and maintain important body functions.
Causes of Algomenorrhea
In medicine, algomenorrhea is divided into three degrees:
- Tolerant or moderate. The pain in which a woman experiences a feeling of discomfort and a slight dull pain, she is fully able to endure such pain without medical intervention, while maintaining a normal lifestyle.
- The average degree of pain is characterized as pulling, dizziness, nausea and chills may be added to it. Often the disease is accompanied by depressive mood and other psycho-emotional disabilities.
- Severe or unbearable pain completely deprives a woman of a normal existence. Menstruation may be accompanied by vomiting, tachycardia and other heart pain. The main cause of algomenorrhea, called medical scientists - is a violation of the hormonal balance in a woman's body. The excess of prostaglandins in the body causes an increase in the number of flat muscle contractions at the bottom of the pelvis.
Pain usually begins a couple of days before the menstrual cycle and lasts for several days. Whether analgin helps with menstruation and is it as safe as many people say - many women are concerned about this issue. Causes of discomfort during menstruation:
- Abortions or other invasive interventions that leave scars on the uterus.
- Contraceptives that are used intrauterinely.
- Varicose veins.
- Infectious-inflammatory processes leading to adhesions in the pelvic organs.
Very often, pain during menstruation is a consequence of benign and malignant neoplasms in the uterus or its appendages. А также на возможные проблемы может указывать дискомфорт при половых контактах, в этом случае необходимо обратиться за консультацией гинеколога.
Analgin with menstruation pain for many has become almost a panacea, so it is possible and even necessary to drink analgin during menstruation. The drug itself belongs to the group of painkillers and non-narcotic drugs. It has an antispasmodic, antipyretic and analgesic effect. On the basis of analgin developed many other drugs of similar action. Another name for Analgin is metamizole sodium.
Analgin or metamizole sodium is often included in the composition of complex tools to combat ailments and side effects. Its action is aimed at enhancing the analgesic effect. The most common complex drugs that can help relieve the ailment are - Akabel, Remidon, Anapirin.
Each drug has its own characteristics, so:
- Akabel is used for cramping pain during menstruation, it has a strong antispasmodic property.
- Remidon has antipyretic properties, it is used for pulling dull or aching pain. It also has a beneficial effect on the nervous system - increases mood and performance.
- Anaprin has the unique properties of both drugs - removes the disease and leads to body temperature in a normal state.
Analgin action on the body
The drug belongs to the fast-acting drugs, as it has a high bio-permeability and easily penetrates into the tissue. The action of analgin is manifested within 20 minutes after its administration. Elimination of the pain effect occurs due to the fact that analginum reduces the conductivity of the pain impulse along the nerve fibers.
The drug affects the receptors of the muscles of the genital organs, as well as when it enters the pain center, it reduces the amount of prostaglandins produced. It stabilizes the cell membrane of the flat muscles, thereby removing the disease and body temperature.
Important! Metamizole sodium retains sodium and water in the body, that is, it can cause puffiness. If the discomfort continues for a month, you should contact your gynecologist for diagnosis or adjustment of treatment.
Indications and Contraindications
It should be understood that in this case analgin is not a curative means of causing the pain, it only eliminates it and possible side effects. The drug can not be used regularly, as it has contraindications and does not affect the cause of the disease. Metamizole sodium significantly reduces the production of leukocytes in the body, which reduces its ability to combat various infectious diseases, and also affects blood clotting, with prolonged use can lead to bleeding.
The main contraindications:
- Various blood diseases.
- Diseases of the kidneys and adrenal glands.
- In no case can not use analgin with alcohol.
- Bronchial asthma.
- Allergy to the drug.
Also, the drug should not be used in acute pain, the reason for this is that it can completely “smear” the picture, in which case the gynecologist will not be able to establish the exact cause of the discomfort, which can lead to improper treatment and serious consequences for the woman. Side effects can occur with very long or haphazard medication use. The most common:
- Nausea and headache.
- Excessive bleeding.
- Renal failure.
- Significant reduction in blood pressure.
It is necessary to abandon the use of analgin with monthly pain, along with alcohol. Thus, the drug at times increases the effect of alcohol on the liver and can lead to serious consequences.
As well as special attention should be paid to the use of drugs with sedatives, as it can enhance their side effects. In any case, before use, you should consult with your doctor.
Mechanism of action metamizole similar to the mechanism of action of other NSAIDs. The substance inhibits (indiscriminately) the activity of the enzyme MOR, which is involved in the synthesis of prostanoids, reduces the formation of some Pg, endoperekis, free radicals and bradykinins, inhibits lipid peroxidation.
The effect of the action cannot be called absolute, as is the case with other NSAIDs, since it can be blocked by stimulating inflammatory receptors.
Interferes with proprioceptive and exteroceptive impulses along Burdah and Gaulle beams, increases the threshold of excitability of pain sensitivity centers in the thalamus and the intensity of heat transfer.
Anti-inflammatory activity metamizole expressed slightly, so the drug has almost no effect on the exchange of water and electrolytes (water retention and Na + ions) and the mucous membrane of the alimentary canal.
Besides pain relief, the drug helps to reduce body temperature during hyperthermia and causes some antispasmodic effect (in particular, relieves spasm of smooth muscles of the bile ducts and urinary tract).
Act metamizole develops in 20-40 minutes after taking the pill, the maximum severity of the effect occurs after two hours.
The results of a comparative analysis of the effectiveness of Aspirin and analgin temperature show that antipyretic activity metamizole less than that aspirinbut at the same time significantly higher if you compare analgin with Paracetamol and Ibuprofen.
Analgesic effectwhen applied metamizole also more pronounced than when used Ibuprofen / Paracetamol.
What is Analgin injection solution for?
Analgin in ampoules is prescribed in exceptional cases: when enteral use of the drug is not possible, to relieve very severe postoperative pain, in situations where you need to quickly bring down the high temperature. Sometimes (quite rarely) injections are used in therapy. arthritis and osteochondrosis.
With moderate pain syndrome (for example, with a headache) it is usually enough to drink a pill.
What helps Analgin when using the drug in the form of suppositories?
Suppositories are intended for the treatment of children over one year of age.
In children, it is advisable to use Analgin for toothache, headache, pain for burns, myositis, radiculitis, neuralgia. Also effective candles with Analgin for pain in the postoperative period.
Contraindications for Analgin
The annotation lists the following contraindications to the use of Analgin:
- hypersensitivity to metamizole, derivative pyrazolone, pyrazolidine(the drug is not prescribed, including to persons who have been identified during the use of these drugs agranulocytosis), auxiliary components of tablets,
- aspirin bronchial asthma in history
- intolerance syndrome simple analgesics or NSAIDs,
- oppression (depression) of the bone marrow or pathological conditions of the hematopoietic system,
- congenital forms hemolytic anemiacaused by a deficiency of the cytosolic enzyme G6PD,
- acute intermittent porphyria,
- unstable hemodynamics and / or arterial hypotension,
- suspicion of acute surgical pathology.
In pediatric practice, tablets are used from the age of ten, suppositories in children older than one year.
Intramuscular medication should not be administered to children up to three months, as well as children weighing up to five kilograms. Contraindications for intravenous administration of Analgin are children from three to eleven months.
Analgin tablets: instructions for use
When using Analgin in tablets, the dosage is adjusted depending on the intensity of pain and the individual response of the body to treatment. The best is the use of a minimum, controlling the fever and pain, dose.
Tablets are swallowed whole and washed down with a large (about 200 ml) volume of liquid.
For an adult with a body weight of more than 53 kg a single dose of Analgin - 0.5-2 tablets. If one dose was not enough, the maximum single dose (two tablets) can be taken three more times during the day. The safe upper limit of the daily dose is 4 grams (eight tablets).
Method of administering Analgin
The method of administering the drug depends on the patient’s condition and the desired therapeutic effect. In most cases, oral administration is sufficient to improve the patient’s condition.
Analgin in / in and / m injected when you need to get the result quickly. When administered parenterally, the likelihood of anaphylactoid / anaphylactic reactions is higher than when taking pills or using suppositories.
Children up to one year, the solution can only be administered intramuscularly. The temperature of the injected fluid should be as close as possible to the body temperature.
The solvent can be used a complex solution of sodium lactate Bieffe (Ringer lactate), a five percent solution of glucose or 0.9% aqueous solution of sodium chloride. Since the given stability of these solutions is limited, they should be used immediately.
Due to the potential incompatibility, Analgin's solution is not recommended for use in one system for IV infusion or in the same syringe with other drugs.
Instructions for use Analgin-quinine
Honors drug Analgin-quininefrom ordinary analgin is that its composition besidesmetamizole sodium (200 mg / tab.) Also includes quinine (50 mg / tab.).
Thanks quinine the drug has a pronounced effect against pathogens malaria - unicellular parasites of the genus Plasmodium (suppressing DNA replication, the substance inhibits the development of erythrocyte forms of malaria plasmodium), and painkillers and antipyretic properties.
Quinine suppresses the center of thermoregulation located in the hypothalamus, and in the case of use in high doses, the visual and auditory zones of the big hemispheres.
The drug is prescribed for pain syndrome of different origin, with infectious and inflammatory diseasesand also (in combination with antispasmodics) at biliary and renal colic.
Often Analgin-quininein gynecology prescribed for conditions after childbirth and abortion.
In accordance with the instructions, the drug is used from the age of twelve. Patients younger than 14 years old tablets should be taken 3 p. / Day. one at a time from the age of 14, a single dose may be increased to two tablets.
Depending on the clinical picture during the day, you can take from one to six tablets (1-2 pieces, 1-3 p. / Day.).
As antipyretic Analgin-quinine without consulting a doctor, you can take no more than three days in a row, as analgesic - no more than five days in a row.
In elderly people, as well as in patients with reduced kidney function and Clcr disorders, Analgin is used at a lower dosage, since the metabolites metamizole sodium they may be eliminated more slowly than in younger patients and patients with normally functioning kidneys.
With reduced hepatic and / or renal function, high doses should be avoided. metamizole sodium. Without dose reduction only short-term use of the drug is possible. Prolonged use is not possible.
Patients receiving Analgin for a long time should regularly take a blood test to count leukocyte count.
Does Analgin lower or increase blood pressure? This question is often asked people who are prone to fluctuations in blood pressure. The manufacturer’s instructions state that the use of metamizol may be associated with the risk of dose-dependent hypotension, as well as hypersensitivity reactions.
Therefore, the expediency of using the drug in a dose exceeding 1 g requires an assessment of the benefit / risk ratio.
The solution is administered under the close supervision of a physician in the position of the patient lying down.
To reduce the risk of a sharp decrease in blood pressure and ensure the possibility of timely cessation of solution administration during the development of anaphylactoid / anaphylactic reactions, Analgin IV should be administered very slowly (the injection rate should not exceed 1 ml / min).
To reduce the adverse effects metamizole on the gastric mucosa, pharmacists recommend replacing the usual Analgin drug Analgin Ultra. These tablets are coated with a protective coating, due to which metamizol less irritating to the digestive tract.
Use of Analgin and Dimedrol
Combination Analgin with Diphenhydramine it is used in critical situations when it is necessary to bring down a very high temperature (including in infants).
One of the most effective means at high temperature, which other means cannot cope with, is the injection of the “trochatka” Analgin-Diphenhydramine—Papaverine. Combinations are equally good. Tavegil, Analgin and No-shpa or analgin, No-shpa and Suprastin on temperature. After intramuscular administration of any of these mixtures, the temperature drops in fifteen minutes.
Papaverine renders antispasmodic and myotropic action, promoting the opening of spasmodic vessels and lower blood pressure, but Diphenhydramine (antihistamine) strengthens antipyretic effect of metamizol and reduces mucosal swelling. All this allows you to increase heat transfer and make the action metamizolemore pronounced.
The undeniable advantage of this composition is that it can be used in situations where the patient can not take a pill (for example, in case of impaired consciousness or indomitable vomiting).
Analgin Dosage, Papaverine and Diphenhydramine depends on the age and weight of the patient. In a properly selected amount, the preparations quickly bring down the fever, but if the inflammatory process has just begun to progress, the effect will remain only for 3-4 hours, and after this time the temperature will start to rise again.
Prick Analgin with Diphenhydramine on the temperature make in the gluteus muscle. The mixture can be used no more than once every six hours.
Contraindications to the introduction of “triad”:
- allergy on the drug, which is part of the lytic mixture,
- abdominal pain due to high fever ( appendicitisthe use of a lytic mixture may cause serious harm).
To check availability allergies a drop of solution is injected into the patient under the lower eyelid. The use of triad is strictly contraindicated if the patient at the same time appear redness or pain.
You should also not give an injection if, during the last four hours, the drugs in the mixture were used in attempts to bring the temperature down (the risk of overdose is high).
It should be noted that the “triad” is a universal means of emergency care with a sufficiently large number of pathologies (including in trauma and surgical patients). In particular, in the ambulance and in the therapeutic hospital, it is used to cupping hypertensive crisis.
Dosage Analgin with diphenhydramine for children
The dose of 50% solution of Analgin for the preparation of the lytic mixture is selected at the rate of 10 mg / kg. 1% solution Diphenhydraminetake at the rate of 0.4 ml for each full year of life of the child (children under one year should take the minimum dose - 0.4 ml).
Dose calculation Papaverine carried out according to the age of the child. For a child under one year, 0.1 ml of the preparation is sufficient; for older children, the minimum dose should be multiplied by the number of full years.
Dosage Analgin, Papaverine and Dimedrol for an adult
For the preparation of lytic mixture for adults and adolescents over fifteen years old with a body weight of 60 kg in one syringe should be mixed 2 ml of Analgin, 2 ml Papaverine and 1 ml Diphenhydramine.
For every next 10 kg of weight, you need to add a tenth of the specified standard dose of each of the substances.
Application of analgin for acne
Analgin is sometimes added to talkers for treatment. acne. To prepare the medicine, mix the powdered tablets. Levomitsetina, Nystatin and Analgin (four each drug) with the contents of one sachet Streptocide and dilute the mixture with one hundred grams of vodka or, for sensitive skin, water.
Symptoms of an overdose of Analgin are manifested in the form of:
- shortness of breath,
- impaired consciousness
- convulsive syndrome.
The likelihood of development is not excluded hemorrhagic syndrome, acute agranulocytosis, hepaticandacute renal failure.
Lethal dose in pills - from 15 to 20 grams.
Treatment: gastric lavage (procedure carried out using a probe), induction of vomiting, the use of saline laxatives and enterosorbentsalkalization of urine holding forced diuresis. In the future, symptomatic therapy aimed at the regulation and maintenance of impaired functions of vital organs.
Effect metamizole reinforce caffeine, codeine, barbiturates, H2-antihistamines. Propranol helps to slow down the inactivation of the substance.
Use of Analgin in combination with tiamazol and sarcolysin can cause development leukopenia. In combination with tranquilizers and sedatives, the anesthetic effect is enhanced. metamizole.
Allopurin, oral contraceptives and tricyclic antidepressantsviolate the metabolism of substances and increase its toxicity.
Concurrent use with NSAIDs or analgesic antipyretic provokes a mutual increase in toxicity, with derivatives phenothiazine - pronounced increase in body temperature.
In combination with myelotoxic drugs hematotoxicity increases metamizole, inducers of microsomal liver enzymes (for example, phenylbutazonea) weaken the effect of the drug.
Metamizole increases activity hypoglycemic agents for oral use Indomethacin, GK and indirect anticoagulants, displacing them from their association with blood proteins. Reduces plasma concentrationcyclosporine.
Application penicillin, colloid blood substitutes and radiopaque substances during treatment with analgin is contraindicated.
What is metamizole sodium?
Metamizole Is a derivative of five-membered heterocyclic lactam pyrazolone, non-narcotic pain reliever.
The gross formula of the substance is C13H16N3NaO4S.
In accordance with the State Pharmacopoeia, the substance has the appearance of a white or slightly yellowish crystalline powder that quickly decomposes in the presence of moisture. It is easily dissolved in water and it is difficult - in ethanol. In chloroform, ether and acetone, it is almost impossible to dissolve the powder.
Wikipedia states that for the first time metamizol was synthesized by German organic chemist L. Knorr in 1920.
Released in the process of biotransformation metamizole the active metabolite may stain urine red.
Reaction Analgin and Hydroperit
Chemists-enthusiasts Analgin with Hydroperit use in order to make a "smoke hood". For this, the components are taken in a ratio of 3: 1 and ground into powder in different (this is very important!) Containers.
When working with reagents, gloves should be worn (when grinding different preparations, different gloves are worn so that the particles Hydroperitand Analgin did not detonate in the hands), and at the end of the work - wash hands thoroughly.
After grinding the tablets, powders from different containers are poured into one jar and mixed. The reaction starts at a temperature of 25-30 ° C.
Synonyms: Baralgin, Analgin Ultra, Optalgin.
Analogs with a close mechanism of action: Akofil, Antipyrine, Bralangin, Pentabufen, Revalgin, Spazmolgon, Tetralgin.
Can I give children Analgin?
Analgin is used provided that other therapeutic measures are ineffective.
Candles are prescribed after a year, pills - from ten years. The solution can be used in children of the first year of life (the route of administration depends on the age of the child).
As a rule, rectal suppositories are most commonly used in younger children with febrile conditions. This method of administration provides a faster flow of the active substance into the blood and thus eliminates its negative impact on the gastrointestinal mucosa.
At a temperature that is poorly strayed by other means, parenteral administration is indicated. metamizole sodium in combination with antispasmodics and antihistamine drugs.
Instructions on tablets for children
Taking a pill for temperature and pain, it is swallowed whole, without chewing, and washed down with a large (about 200 ml) volume of liquid.
If the drug is used to reduce the temperature, a single dose for patients under the age of fourteen years 10 mg / kg, if for the relief of pain - from 8 to 16 mg / kg.
Adolescents over fifteen years old, the dosage in tablets at one time - up to 1 g metamizole (two tablets). If this does not allow to achieve the desired effect, the highest single dose can be taken three more times during the day. The permissible upper limit of the daily dose is 2 g.
10 mg / kg is usually enough for children to reduce their fever. metamizole.
In children under the age of fourteen, a single dose varies from 50 to 900 mg (or from 8 to 16 mg / kg). The dose and method of administration of the drug is determined depending on the age of the patient.
Single dose for adolescents weighing from 46 to 53 kg - from 400 to 900 mg (0.8 to 1.8 ml of solution). Teenagers weighing more than 53 kg of Analgin prescribed in the same dosage as an adult.
Use of a dose exceeding 1 g is associated with the risk of developing antihypertensive reactions.
Instructions for candles with analgin for children
Candles are administered rectally. The daily dose for children from 12 months to three years - one suppository 100 mg. For children 4-7 years old during the day, you can enter two suppositories of 100 mg (first one suppository is administered, and after 4-6 hours - if necessary, the second) or one 250 mg suppository.
In children of 8-14 years old, 1-2 suppositories of 250 mg are administered during the day (one each, with an interval of 4-6 hours between injections).
After applying the drug, the child should still lie down for half an hour.
The duration of treatment depends on the clinical situation and usually ranges from 1 to 3 days.
Can Pregnant Analgin?
There are no sufficient data on the use of Analgin in pregnancy. The safety category for the fetus in accordance with the FDA classification is not established.
Absolute contraindications for use - the first three and the last six weeks of pregnancy. In the second trimester, application is possible based on the results of the risk / benefit assessment.
Is it possible to take analgin when breastfeeding?
With lactation use of the drug is contraindicated. In exceptional cases, feeding is resumed 48 hours after the solution / tablet has been injected.
Analgin is a time-tested universal, potent and very affordable. anestheticwhich helps well from the head, from the pains arising during menstruation, rheumatism, neuralgia and arthralgia.
Reviews about the drug are quite contradictory: on the one hand metamizole sodium works reliably, and is effective even with severe pain, on the other - it has a large number of contraindications and side effects (which is why it is prohibited to use in most developed countries).
Most people agree that it is possible for adults to take Analgin, but not abusing it, but for children (especially small ones) it is better to choose a safer alternative.
How much does Analgin cost?
Price Analgin tablets in Russian pharmacies - from 8 rubles. The cost of ampoules - from 85 rubles. You can buy suppositories on average for 35 rubles. Price Analgin-quinine - from 58 rubles.
Price Analgin tablets in Ukraine - from 4 UAH. Rectal suppositories can be bought for 11-13 UAH. Analgin price in ampoules - from 25 UAH.