Estradiol (E2) is the most active estrogen. Despite the fact that the hormone is female, its presence in the body of a man is fully justified by the important functions that it performs.
The fifth part of estradiol is synthesized by cells located in the testicles. Most of the hormone is produced by flavoring androgens, mainly testosterone. And this process takes place in peripheral tissues. The amount of estradiol synthesized per day in the male body is up to 40 micrograms.
At the same time, there is a feedback between him and testosterone: the more estradiol, the smaller the main male hormone, and vice versa. Therefore, it is very important to maintain a balance between them.
The value of estradiol for the body of men
Both the presence and production of estradiol in the male body are necessary, since the hormone performs the following functions:
- reduces the likelihood of developing cardiovascular diseases and pathologies, contributing to the development of "good" cholesterol,
- helps to keep bones filled with calcium and strengthened
- participates in the production of sperm and controls this process, responsible for maintaining sexual function and attraction to the beautiful half,
- strengthens fertility, that is, the ability to fertilize (without estradiol, sperm can lose it),
- activates the exchange of oxygen
- favors an increase in blood clotting,
- stimulates the normal passage of metabolic processes,
- improves the functionality of the nervous system
- activates hair growth and protects against baldness,
- regulates the production of gonadotropins - pituitary hormones, which are responsible for the effective work of the sex glands.
Without estradiol, the body of a man would have to be bad. The main thing is to keep its quantity within the normal range, and then the hormone will only improve the quality of life.
Estradiol in men: normal
It is necessary to control the content of the hormone, since noticeable and prolonged deviations from the norm cause:
- mental disorders and loss of ability to control one’s emotional state,
- excessive anxiety and uncontrollable irritability,
- feeling of chronic fatigue
- decrease in the amount of testosterone.
This state weakens all the sexual impulses that the brain sends. The decrease in testosterone also leads to the fact that men begin to develop external signs of femininity.
The normal level of estradiol is in this range (pg / ml):
Finding a substance in these limits for the body of men is optimal.
With age, as well as obesity, the amount of the hormone increases. Affects the estradiol content and time of year. Its highest level is observed in the autumn months.
The amount of estradiol is measured in picomoles per liter of blood. In these units, the normal hormone content is:
In some private laboratories, the norm indicator has the following range: 12–45 pc / mol.
Therefore, it’s not worth judging whether estradiol is normal. Only doctor can interpret test data accurately.
Estradiol exceeds the norm: symptoms and causes
A condition in which the estradiol content exceeds the norm is called hyperestrogenic. Among the problems associated with impaired reproductive male health, it is observed no more often than in 3% of cases.
When the amount of estradiol in the body of a man steps beyond the upper limit of normal, it is manifested by the following signs and symptoms:
- muscles begin to become decrepit and they are very difficult to tone up,
- swelling due to lack of sufficient water drainage,
- fat deposits appear in the thighs, abdomen and buttocks, giving the body a female shape,
- libido goes down,
- the mammary glands are enlarged, soreness appears even with a slight touch to them,
- the amount of hair is significantly reduced (it happens not only on the head, but also on the body),
- sleep is disturbed (sleep is not easy, and waking up is even harder),
- problems in the digestive tract (frequent constipation and diarrhea),
- there is often coldness in the limbs.
All these symptoms are unpleasant. But the consequences of the growth of the mammary glands (gynecomastia) at a certain stage may become irreversible. If hormone therapy saves in the early stages, then in severe cases only a plastic surgeon can help.
Elevated estradiol can lead to the fact that a man who has never experienced pressure drops begins to suffer from hypertension.
Possible reasons for the increase in the amount of the hormone are:
- Adverse reaction to taking certain medications, in particular, anabolic steroids.
- Serious liver diseases, primarily cirrhosis.
- Tumor formation in the testes.
- Excess hormone prolactin levels.
- Too much exercise.
- Unbalanced diet: abuse of carbohydrates and low-fat foods.
- Weight gain in a short time.
Obesity affects the amount of estradiol negatively: the higher its degree, the greater the likelihood of an increase in the level of the hormone. This is due to the fact that estradiol is produced in adipose tissue.
Often in men there is a decrease in the amount of estradiol. This is no less desirable than his height.
Among the main reasons for reducing the hormone are the following:
- The rapid weight loss, which resulted in the destruction of estrogen, located in adipose tissue.
- Chronic prostatitis.
- Heart Disease.
- Pathology of the pituitary gland.
- Inflammatory processes in the genitals.
- Acceptance of hormonal and some other drugs.
- Endocrine pathology.
- Primary and secondary hypogonadism - testicular failure, which is accompanied by low levels of sex hormones. The disease is caused by organic pathology of the male testicles.
To reduce the content of estradiol are capable of frequent and intense exercise. Smoking addiction not only poisons the body as a whole, but also can lead to a drop in hormone levels.
Its lowered number is often observed in those who refused to eat food of animal origin and became interested in vegetarianism.
Excessive changes in the level of estradiol can lead to serious and undesirable processes in the body of a man.
The doctor prescribes an analysis of the content of the hormone in cases where the patient has become evident such symptoms:
- too late or before puberty,
Be sure to set the concentration of estradiol and suspected tumors in the genitals.
To determine the level of the hormone in the body, it is necessary to pass venous blood for analysis.
To the results of the study were correct and did not lead to unnecessary unrest, it is necessary to adhere to certain conditions.
At least 48 hours you need to refrain from:
- trips to the gym or intense physical labor,
- strong drinks
- tobacco smoking
- having sex.
As with any other analysis, blood must be donated on an empty stomach, preferably in the morning.
Estradiol is one of the important hormones necessary for a man’s life to be complete. Although it is relatively small, even a minor deviation from the norm can disrupt the usual functioning of muscles, bones, such systems as urinary and cardiovascular.
Elevated or lowered hormone levels are not a disease. This is just one of the manifestations of a particular disease. Therefore, it is necessary to undergo further examination and to identify the specific diseases that caused the problems. Getting rid of them, the body will produce a hormone in the optimal amount.
Determination of hormone concentration
The rate of content in men is 16-72 pg / ml or 40-161 pmol / l. The rate is determined by the interpretation of blood tests. It may fluctuate according to age or season.
Deviations from the norm, however, are not diseases, but can provoke their appearance. All visual symptoms of imbalance can not manifest at the rate shown by the analysis.
The reason for which the concentration changes depends on the direction in which the level has changed (it has become low or high). Depending on what is observed: the increase or decrease in the level determines the further actions in the treatment plan, and the necessary medications are prescribed.
Before the course of medication must have the results of the analysis. Thanks to the analysis of blood drugs are selected.
In case of detection of visual signs, it is necessary for men to donate blood for analysis. Responsible for important functions, an imbalance at the concentration of the hormone in question can lead to serious consequences, and the normal functioning of the body becomes impossible.
Elevated estradiol in the male body is accompanied by symptoms such as:
- the inability to control their behavior and mental disorders,
- chronic fatigue,
- decrease in the level of testosterone in the blood.
Subsequently, increased levels of the hormone:
- obesity develops
- sexual activity decreases,
- There are difficulties with building muscle,
- hair on the face or chest disappears (these signs indicate that the body has testosterone deficiency) - all these are indications that men have elevated levels of estrogen.
High estradiol causes the appearance of female symptoms. An increased concentration of the "female hormone" in relation to the "male" can lead to problems with the liver or organs of the reproductive system.
A separate case of increasing hormones is gynecomastia. This is because an increased level of estradiol in men causes the appearance of female symptoms.
Gynecomastia - an increase (tumor) of the mammary glands in a man with elevated estradiol. The tumor is always benign.
- hormonal changes in adolescence,
- hormonal imbalance, due to which the male body has a low testosterone level.
This case is rare. In gynecomastia, male signs begin to be replaced by female ones regarding the ratio of hormones.
Treatment with elevated estradiol
Gynecomastia treatment and simple therapy with elevated estrogen levels are aimed at restoring the humoral balance.
In the case of a high level, it is necessary to increase the testosterone content in the blood; therefore, drugs that reduce the amount of estrogens are used.
Symptoms of the disease are eliminated and do not require additional medication to reduce or stop. In this case, two treatment options are selected:
These drugs are aimed at blocking the synthesis of estrogen, do not allow estradiol to be produced in the body and reduce its concentration in the blood, thereby increasing the synthesis of testosterone.
Often two drugs are prescribed: Tamoxifen or Clomiphene. In this case, the treatment is directed directly to how to lower the level of this hormone in the blood, and compensate for all the "male" hormone - testosterone.
Such drugs suppress the synthesis of the aromatase enzyme, not allowing testosterone to turn into estrogen, but at the same time without lowering estradiol in men, but preventing the synthesis of its excess. Drugs for treatment in this case: Cytadren or Arimidex.
This medication is prescribed to normalize the ratio of different hormones. This treatment is more effective. It is aimed directly at reducing the synthesis of estradiol.
Reception of drugs, their dosage and time of treatment should be prescribed by the attending physician. In the case of non-compliance with the doses or self-treatment, it is impossible to restore the normal level of the hormone in the blood.
Excessive consumption of these drugs reduces the concentration to a lower than normal. Reduced concentration suggests more serious consequences.
A decrease in estrogen levels is also undesirable, as is an increase. If low estradiol is detected, the following symptoms are observed:
- weight and muscle mass reduction
- cardiovascular and genital diseases,
- hormonal pathologies,
- lack of male sex hormones.
In this regard, reduced estradiol may be more dangerous than elevated, as it causes more serious diseases.
Also, in the case of a reduced level, sexual activity and fertility are reduced.
Treatment with low estradiol
How to raise the level of this hormone interests many who have similar problems. In this case, treatment may not be made because estrogenic drugs can dramatically increase synthesis. As a result, the level of estrogen in the blood will rise rapidly, and this can have much worse consequences. At a concentration below the lowest, there are no clear symptoms to start a course of medication (if it is not accompanied by other diseases).
Also, a decrease in the concentration of hormones of this type can occur with natural causes, such as aging and loss of fertility.
Estrogen drugs can only be prescribed if the man has prostate cancer or polycythemia. In addition, during treatment, it should be remembered that other drugs, androgynes, are contraindicated.
In this case, it is necessary to directly increase estradiol. Without concomitant diseases, treatment is not prescribed when a low value is detected, and if they are present, their effects are mostly stopped.
What does a man need him for?
In men, estradiol is several times less than in women. It is produced by the testicles and adrenal cortex, and also synthesized in small quantities from cholesterol. This hormone is of great importance because it is responsible for many vital processes:
- Participates in blood coagulation.
- Promotes the production of seminal fluid, which directly affects the ability to fertilize.
- It reduces the level of harmful cholesterol, preventing the development of atherosclerosis.
- Regulates metabolic processes.
- Responsible for the normal functioning of the cardiovascular system.
- Prevents the development of osteoporosis, provides strength to the bones.
- Normalizes the activity of the nervous system.
An increase in one hormone in relation to another inevitably leads to serious consequences for the health of a man. There is a negative impact on the psycho-emotional state. The constant chronic fatigue and increased anxiety “on trifles” can become a reality.
If the concentration of estradiol is normal, then the man is sexually active, has an optimal body weight and muscle strength.
Norm estradiol in a healthy man
In a healthy male body estradiol should be from 16 to 72 pg / ml.
These indicators were approved after many clinical studies and are considered the norm. But keep in mind that in some laboratories indicate lower values. Doctors call an increased content of female hormones hyperestrogenemia. It usually develops on the background of any disease, or as a result of medication intake of estrogen in the body.
In order for the results of the analysis to be as reliable as possible, it is necessary to carefully prepare for the upcoming study. A few days (at least 3 hours) before donating blood, you need to stop smoking, eliminate excessive exercise. It is advisable not to have sex. Drinking alcohol is unacceptable. Even carbonated water is not allowed on the day of analysis. You can drink plain water.
Be sure to stop (after the permission of the doctor) taking steroid and thyroid hormones 48 hours prior to analysis.
Short estradiol in brief
Pathology is considered to be not only elevated, but also reduced levels of estradiol in men. Insufficient production of this hormone, as well as excess, manifests itself in the form of certain signs.
Low estradiol threatens with the development of osteoporosis, chronic prostatitis, cardiovascular pathologies, infertility, etc.
The main reasons for its reduction in estradiol in men:
- Smoking cigarettes.
- Increased exercise.
- Long-term use of certain drugs.
- Disorders in the functioning of the thyroid gland.
- Lack of fat in the diet, excessive consumption of carbohydrates.
- Pituitary dysfunction.
- Increased prolactin levels.
- Sharp decrease in body weight.
- Inflammation of the prostate gland.
Hormonal imbalance in most cases is a cause of disruption of the internal organs and systems. Therefore, when planning a pregnancy, both partners are examined. Often the problem lies in the increased estradiol, which does not allow a man to become a father.
Causes and signs of increased estradiol in the body of a man
Elevated estradiol in men has a number of signs that are easily recognized by external signs. Excessive production of female hormone in men is manifested in the following symptoms:
- decreased libido
- the appearance of edema,
- ожирение по женскому типу – возникновение отложений на бедрах, животе, ягодицах, набухание молочных желез,
- уменьшение оволосения на лице и на теле,
- ineffectual physical training without gaining muscle mass
- sleep disorders
- frequent mood swings
- weakness and lethargy.
With such signs, you must consult a doctor. Never self-medicate!
To fix the problem you need to find out the reason. This is possible only after a thorough comprehensive examination. Most often, the "culprits" are diseases such as diabetes, liver cirrhosis, and malignant tumors in the reproductive organs. Often obesity, metabolic failures, intoxication of the body leads to increased estradiol in men while taking drugs or alcohol, etc.
Gynecomastia in men
One of the consequences of hyperestrogenia is gynecomastia. With this pathology in men, the mammary glands increase, become similar to the female. The causes are usually diseases that trigger a decrease in testosterone levels, as well as obesity, hormonal changes in the pubertal period of development, and anabolic steroids.
Gynecomastia goes away after hormonal recovery.
Treatment of elevated estradiol in men
In identifying violations of estradiol standards, timely and effective treatment should be carried out. When the female hormone is overproduced, doctors prescribe special anti-estrogen drugs based on such substances as clomiphene and tamoxifen. These components block estrogen receptors.
Attention! Never self-medicate. It is dangerous for health. Only a doctor can write prescriptions!
There are medicines whose action is aimed at stopping the transformation of testosterone into estradiol. They are based on the following substances:
- Vitamin C.
- Anastrozole and others
With insufficient synthesis of estradiol, hormone replacement therapy is carried out. Medication on the basis of this substance is carried out under strict medical supervision. Self-medication is unacceptable in any case, because uncontrolled use of hormonal medications leads to obesity, liver problems and other serious consequences..
The main conditions for a stable hormonal background are a healthy lifestyle, a complete rejection of alcohol and cigarettes. Equally important is proper and complete nutrition, frequent consumption of fresh vegetables and fruits, regular ingestion of meat and dairy products, fish. Recommended sports training, physical activity, avoidance of stress.
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Features of the hormone, its function in the male body
What is estradiol in men? This hormone is produced mostly by the testes, but a certain amount of it is produced by the adrenal cortex. This substance has a close relationship with the male sex hormone testosterone. It is noteworthy that the intensive development of the first leads to a decrease in the synthesis of the second. In order for the organism and, in particular, the sexual sphere to function without deviations, it is important that the indicators of both of these elements are always within the normal range.
Estradiol Functional Tasks
What is estradiol responsible for men? The hormone is needed by the male body for:
- normalization of metabolic processes,
- stimulation of the process of assimilation of oxygen by all cells and tissues of the body,
- maintaining and regulating the functioning of the nervous system,
- regulation of the endocrine glands, responsible for the production of sex hormones in men,
- reduce the likelihood of developing CVD diseases,
- increase in blood clotting,
- prevent alopecia.
In addition, estradiol in men, which is within the normal range, supports the process of sperm production, as well as increases sperm motility, which contributes to the successful fertilization of the egg.
Note. This hormone is also important for the male body in that it prevents the development of such a dangerous bone disease as osteoporosis.
Indicators of the norm of the hormone. Estradiol Analysis
The norm of the hormone estradiol in men, according to most experts, is of great importance for the health of patients. As can be seen from the previously considered functions of this element, he takes an active part in many processes occurring in the male body. Consequently, any deviations immediately lead to a malfunction of some systems.
Normal levels of estradiol in men are indicators that vary between 16 and 72 pg / ml of blood. But the results in some laboratories can vary significantly, so sometimes the data of 11.7 - 41.3 pg / ml are also considered the norm.
For convenience, the rate of estradiol in men by age is presented in tabular form. Indicators are recorded in picomoles per liter of blood (pmol / l).
The content of the hormonal element in the blood of men is influenced by numerous factors. Age is the main one, but the patient’s body mass and even the time of year have a direct impact on the level of the substance.
Analysis of estradiol in men is necessary to control its level, and must be carried out necessarily, since this is the only way to timely detect deviations and prevent possible adverse effects. The study is indicated in the presence or suspicion of the presence of:
- deviations in sexual development,
- malignant neoplasms in the genital area.
A blood test for estradiol in men is performed on an empty stomach. The patient should stop smoking on the day of the study, avoid alcohol and sexual intercourse on the eve of the biomaterial sampling. Intense exercise can also affect the test result, so they should also be eliminated.
Causes and signs of excess estradiol in men
Estradiol in men increased - what does this mean? Such a deviation does not always signal a serious malfunction of the body. Sometimes it can be the result of long-term use of hormonal drugs. If the increased secretion of a biological substance is caused precisely by this factor, there is nothing to worry about: after the termination of hormone therapy, the indicators will gradually return to normal.
But the reasons that estradiol in men is significantly elevated, and its level is not normalized, may lie in the presence of serious pathologies:
- cirrhosis of the liver,
- tumors in the testicles,
- severe obesity.
Such pathologies cause noticeable changes in the functioning of the male body, and require mandatory medical intervention. Self-medication for estradiol above the norm in men can lead to dangerous consequences.
Signs of excess estradiol
The situation when estradiol is elevated in men is accompanied by the following symptoms:
- pronounced swelling of the arms, legs, face,
- decrease in muscle mass and difficulties in building it,
- loss or decrease in libido,
- reducing the amount of hair on the body,
- the appearance of features of a female figure, especially in the area of the buttocks, breasts, thighs.
If estradiol e2 in men is constantly increased, this leads to:
- frequent and uncontrolled mood swings,
- causeless anxiety,
- development of CFS.
In addition, a surplus of hormone substances leads to a decrease in testosterone production, which leads to impaired reproductive function.
Estradiol deficiency in men: causes and signs
Low estradiol in men is no less common and dangerous than high. Among the factors that can lead to such a deviation, are placed in the first place:
- excessive physical activity
- wrong approach to hormonal drugs,
- lack of protein in the consumed food,
- poor nutrition,
- tobacco smoking
- dramatic weight loss.
Interesting fact. Estradiol below normal is also observed in men who are addicted to vegetarianism. For normal synthesis of the hormone, protein is necessary, and its deficiency can cause disruptions in the production of not only this, but also many other hormonal elements.
The reasons for the decrease in the level of a biological substance may also lie in the development of pathologies of the endocrine system, as well as in inflammatory diseases of the sex glands.
The symptoms of low estradiol in men are similar to those with a high level of this substance. Patients have a decrease in sexual desire, which leads to low sperm motility. As a result, there are serious difficulties with fertilization of the egg.
Against the background of a decrease in estradiol, blood testosterone levels increase. This is also not the norm, so this condition requires urgent intervention by medical professionals.
Based on this, the question arises: how to increase estradiol in a man? This can be done naturally by eating a sufficient amount of protein foods, a rational approach to physical exertion and abandoning bad habits.
In some cases, special medical preparations may be prescribed for hormone replacement therapy. Independently they can not be taken, because you can make a mistake with the dosage, and seriously harm your health!
Causes of increased or decreased estradiol in men
Low estradiol in men can be observed in the following cases:
- heart disease,
- pituitary disorders,
- significant loss of body weight
- bad habits,
- chronic prostatitis,
- excessive exercise
- following a vegetarian diet
- therapy with certain drugs (for example, hormonal drugs).
Elevation of the hormone can be relative or absolute. With a relative change in the ratio of estrogen and androgen in favor of the first. The absolute increase is due to excess levels of estradiol in the blood, which is observed in the following pathologies:
- swelling of the liver, pituitary, lungs,
- cirrhosis of the liver, the development of which served as viral or alcoholic hepatitis,
- estrogen-producing tumors of the adrenal glands or testicles.
Also the reasons for the increase in the level of the hormone can be:
Symptoms of increasing estradiol in men
Among the total number of reproductive disorders in men, an increased level of the hormone is detected in about 3% of cases.
The following symptoms indicate a high estradiol level:
- female obesity,
- loss of muscle mass
- reducing the amount of hair on the face and body,
- decreased libido
- cold extremity
- fast fatiguability,
- frequent constipation and / or diarrhea.
When late correction of elevated levels of estradiol in males may have negative consequences, namely:
- myocardial infarction,
- arterial hypertension,
- reducing the size of the genitals,
- erectile disfunction,
- benign or malignant neoplasms of the prostate.
How to lower estradiol in men
The choice of a method for correcting the level of a hormone directly depends on the reason that increased it. It is not recommended to self-medicate in cases of high concentration of the hormone in the blood, as this may aggravate the violation.
For medical correction of the level of the hormone, anti-estrogen drugs may be prescribed. In cases of metabolic disorders, it is possible to use antioxidants, which can both reduce estradiol in men and prevent the development of cardiovascular diseases. If the increase in the level of the hormone served as medication, to bring the indicator to normal in most cases, it is enough to cancel them. The high level of estradiol associated with diseases of the endocrine system is corrected by means of hormone replacement therapy.
An increase in the hormone concentration associated with exposure to toxic substances can be normalized with the help of hepatoprotective and detoxification treatment. If the cause of the tumor, conduct surgery and subsequent hormonal therapy.
The initial stages of gynecomastia, the development of which has led to an increase in estradiol, are adjusted by means of hormonal treatment, the later stages by means of plastic surgery.
In all cases, a lifestyle change is recommended, in particular - diet. First of all, spicy, fatty and smoked food should be excluded from the diet, consumption of animal fats, sugar and alcohol is limited. It is important to eat fresh vegetables and fruits daily, as well as seafood rich in omega-3-polyunsaturated fatty acids. As a consequence of the increased content of the hormone in the blood is weight gain, it is recommended to reduce caloric intake and adherence to the principles of fractional nutrition. Equally important for weight loss is regular exercise, but it should not be excessive.
The clinical significance of estradiol deficiency in male patients has not yet been established. In this regard, given the possibility of side effects, the feasibility of estrogen therapy in men with low hormone levels is questionable.
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What is this hormone
Often there is a question about a substance like estradiol - what is it in menwhat it is for and what functions it performs. This hormone is present in the male body in minimal quantities, it is formed in fat and muscle cells through the conversion of another hormone, testosterone. And also a small amount of estradiol is synthesized in the adrenal cortex and testes.
Estradiol is present in the body of both men and women. And if the representatives of the weaker sex, this hormone normalizes the menstrual cycle, reproductive function, as well as the formation of secondary sexual characteristics.
Androgen is involved in the following processes:
- development of seed secretion by the genitals,
- blood supply and nutrition of internal organs,
- full functioning of the nervous system
- erectile function.
Asked what is estradiol in menIt is important to understand that both increased and decreased levels of androgen in the body lead to a serious hormonal imbalance and can cause many diseases.
The effect of the hormone on the male
Male estradiol levels and its abnormality is extremely important for the proper functioning of the reproductive organs. This androgen performs the following functions:
- Normalizes blood formation and the process of blood clotting.
- Improves the state of the cardiovascular system, reduces the level of cholesterol in the blood.
- Makes the bone apparatus more robust, due to the active accumulation of calcium.
- Takes part in the metabolism, accelerates the burning of fat deposits.
- Improves spermatogenesis.
- It activates the saturation of cells with oxygen.
- Normalizes the emotional state of the man, "responsible" for activity and good mood.
Estradiol for men It is very important that in case of violations in the production of this hormone, a man expects a decrease in muscle mass and female obesity. This means that the fatty layer begins to accumulate in the area of the mammary glands, abdomen and hips.
And also answering the question - estradiol, what is this hormone in men Doctors emphasize that it is the lack of production of this substance leads to a rapid change in the emotional background. A person begins to be disturbed by sudden mood swings, insomnia, chronic fatigue, apathy, unreasonable anxiety and anxiety.
Indications for clinical analysis of estradiol
Analysis of estradiol in men It is recommended if a person notices manifestations of hormonal imbalance. Symptoms of increased estradiol in men somewhat different from the clinical picture, which manifests itself at a reduced level of the hormone.
The main indications for clinical analysis:
- too early or late puberty,
- the development of gynecomastia - that is, a pathological increase in the mammary glands,
- suspected development of a malignant or benign tumor in the pelvis.
Raised or lowered estradiol in men, symptoms which may vary depending on the age and state of human health, is determined by a blood test taken from a vein. The analysis should be carried out on an empty stomach, 24 hours before the meeting, it is absolutely not recommended to play sports, use alcohol or have sexual intercourse.
Normal hormone in a healthy man
Measured norm of estradiol in men in pg ml - picogram per milliliter. Doctors believe that the optimal indicator of a hormone in a man’s blood is 15–70 pg / ml or 40/160 p / l. As a result of numerous clinical studies, it was found that such indicators allow the male body to fully function.
It should be noted that each laboratory conducting clinical tests for determining the level of the hormone has its own principles for interpreting the results obtained. This must be taken into account, since in some laboratories the indicator is considered to be the indicator of 11.8–41.3 pg / ml. That is why only a specialist should decipher the study.
Low estradiol levels
Low estradiol in men can be determined by the results of a clinical blood test. Such a pathological condition can have dangerous consequences for the body. To the main reasons that male estradiol lowered, include the following:
- Long smoking.
- The inflammatory process in the prostate gland.
- Frequent grueling physical exertion.
- Absence in the diet of animal fat, vegetarianism.
- Rapid weight loss.
- Pathology of the endocrine system.
- Long-term use of certain drugs.
And reduced estradiol in men may be caused by various cardiovascular pathologies, various forms of osteoporosis. This condition causes many negative consequences for the male body.
How to increase estradiol?
Most often the causes of a pathological decrease in the level of the hormone in the body becomes a way of life - frequent drinking, smoking, unhealthy diet, constant stress. Such a negative result can lead to a complete lack of physical activity, as well as a fanatical passion for sports, long and grueling workouts. Quite often, hormonal imbalances in men develop after taking steroids, that is, drugs designed for rapid muscle building.
In order to learn how to increase estradiol in men, you must consult a doctor, be examined and tested. After that, the specialist prescribes the patient hormonal medicines that contain artificially created estradiol. This helps to compensate for the lack of androgen and normalize the hormones in the body.
You can increase the level of androgen in the body after a thorough correction of lifestyle. It is very important to eat right, eat enough fats of animal origin, as well as products containing vitamins, carbohydrates and proteins. A man who wants to normalize the hormonal balance in the body, you must try to avoid stress, fully relax, exercise regularly.
Elevated estradiol in men - This is a pathological condition that is also known as hyperestrogenism. If the hormone estradiol in men increasedcauses may be physiological or pathological. Physiological factors are directly related to the physical condition of the human body. Most often these are strong nervous shocks, excessive physical exertion, strict diets. Pathological causes of an increase in the hormone are various diseases that can be both acute and chronic.
High estradiol in men may be caused by the following reasons:
- obesity, metabolic disorders,
- hyperplasia of the adrenal cortex, which synthesizes estradiol,
- alcohol or drug intoxication,
- cirrhosis of the liver,
- diabetes mellitus, thyroid pathology,
- malignant neoplasms in the testes and other pelvic organs.
In some cases estradiol is elevated in men after taking medications or folk remedies, which include phytoestrogens - natural analogues of female sex hormones.
Elevated levels of estradiol in the male body has the most unpleasant consequences, which can be expressed as follows: the figure takes on a feminine and rounded shape, the mammary glands swell and increase. A man may be disturbed by a rapid increase in weight - at the same time, those extra pounds accumulate in the area of the hips, abdomen and chest, that is, by the female type.
When a hormonal imbalance in a person greatly decreases the level of libido, sexual desire can completely disappear. The characteristic symptoms of hyperestrogenia are sleep disturbance, an unstable emotional state, constant fatigue and lethargy.
If estradiol in men increased, causes only a doctor will help to establish, so in no case should you postpone a visit to the clinic.
How to lower estradiol?
In order to learn how to lower estradiol in men, it is necessary to establish the exact cause of the pathological condition. The main goal of treatment is precisely to eliminate the root cause of hyperestrogenia, which contributes to the normalization of the hormonal background in the body.
Drug treatment of hormonal imbalance is carried out with the help of drugs from the group of antiestrogens. In most cases, doctors prescribe Climofen or Tamoxifen. How to reduce estradiol in menwhat specific medication is used, the duration of treatment, the optimal dosage of the drug, only the doctor gives the answers to these questions. If the pathological condition has developed on the background of an oncological disease in the small pelvis, a surgical intervention is recommended.
Effectively lower estradiol in men it is possible by changing the usual way of life, proper, balanced diet, rejection of bad habits. It is very useful to regularly use green tea with mint, nuts, legumes, parsley and other greens, buckwheat, citrus. Doctors advise men to pay sufficient attention to sports, walking in the fresh air, and quality recreation.
Modern pharmacology offers a large number of drugs, which include estradiol. They are widely used in medicine - most often for the manufacture of various contraceptives.
If you use hormones yourself, the risk of side effects is extremely high:
- intense headaches and dizziness,
- development of gallstone disease,
- rapid increase in body weight
- hepatic dysfunction
- emotional instability, sudden mood swings.
It should be remembered that any contraceptive drugs with estradiol can be used only after prior consultation with the doctor.
Gynecomastia and Hyperestrogenia
Gynecomastia is one of the most common manifestations of hormonal imbalance in the male body. It represents swelling and an increase in the mammary glands, with the result that the male breast visually resembles the female breast.
In the case of oncological neoplasms in the testes, increased estrogen production, a man may develop hyperestrogenia, a condition in which the production of male sex hormones decreases, and the level of estrogens increases and exceeds the number of androgens.
These conditions provoke serious changes in the male figure, the acquisition of feminine, rounded features, lack of sexual desire and other problems in intimate life.
What is estradiol in men responsible for?
Estradiol in men is found in the body in much smaller quantities than in women. In men, this hormone is not produced, but is synthesized from cholesterol. However, he is responsible for a number of very important biological functions:
- sperm production
- prevention of osteoporosis,
- nervous regulation
- exchange processes
- oxygen exchange,
- blood clotting
- vascular elasticity.
Estradiol and testosterone constantly fight in the male body. Increasing the level of the female hormone causes a drop in testosterone levels and the corresponding consequences.
And the norm of estradiol provides a man with a stable weight, muscular strength, as well as healthy sexual activity.
In addition, the hormone is responsible for a stable emotional state. The imbalance of estradiol causes, at first glance, causeless deterioration of health, mood swings, chronic fatigue, anxiety, irritability, etc.
The role of estradiol in men
About 40 micrograms are synthesized daily, in which 20% is produced in the ovaries, and 80% is produced in the adrenal glands. Without exaggeration, the main estrogen - this estradiol in men. The main and most significant functions of estradiol in men:
- Reducing the onset of cardiovascular disease.
- Decreased bone density.
- A beneficial effect on the reproductive function of men.
- Increased blood clotting.
- Increase the metabolic rate in the body.
- Activation of oxygen metabolism in tissues.
The normal level of the hormone is 13−54 pg / ml, according to some other data, the rate of estradiol in men about 3−70 PG / ml, so that on average can be considered 10−30 PG / ml normal. You can also take into account the measurement in pmol / l, in which 40–160 pmol / l will be considered the norm. If the result of the analysis was given in pmol / l, it will not be difficult to convert these units to others.
Effect on hormones
To assess the hormonal status, blood is taken, the amount of estradiol and its ratio to testosterone is determined. The norm of estradiol in the blood of men is the ratio of 1 to 300. This amount of hormones ensures stable functioning of the body. If the hormonal state is disturbed, that is, the level is lower or higher than the norm, specialist intervention will be required to normalize the hormonal background.
Factors affecting estrogen levels:
- Abuse of Enhancement Products hormone level: beer, coffee and caffeinated beverages, soybeans and beans.
- Eating spicy, fried and sweet foods.
- Genetic abnormalities.
- Impaired health and liver damage.
An increase in the amount of estrogen in the male body is called hyperestrogenemia. If estradiol in men is elevated, the reasons may be different. Excess hormone is mainly associated with cirrhosis of the liver, testicular tumor, the use of anabolic steroids. Also, an increase in hormone levels is dependent on overweight.
With a long-term sustained increase in estradiol in the blood, serious disturbances occur, for example, gynecomastia.
Gynecomastia is a hypertrophy of the mammary glands, expressed by an increase and sagging of the breast.
To cure such a disease is possible only by surgery. In addition, blood pressure rises and the chance of a stroke increases.
High estradiol is observed in professional athletes, whose progress depends on the courses of anabolic steroids.
To reduce in this case, you will need to take aromatase inhibitors or antiestrogens.
- Anti-estrogens restrain the hormone levels at a normal level, but after the cancellation, the amount of the hormone in the body may rapidly increase. This drug is suitable only in the case of increased endogenous testosterone.
- Aromatase inhibitors are drugs that reduce the concentration of the hormone in the blood and increase level endogenous testosterone.
To lower the level of the hormone, the first thing you need to change your lifestyle, get rid of excess weight. Then adjust the diet, including in the diet seafood, fresh vegetables, fruits and eliminating fatty, salty, smoked, spicy foods. It is necessary to reduce alcohol consumption.
With the increase caused by the use of drugs, you should abandon them. You can find out from a highly qualified doctor using the right advice. how to lower estradiol in men.
Increasing the level of hormones as a result of the tumor will not do without surgery.
Estradiol is the most active of the hormones of a number of estrogens. In the female body, it is synthesized to maintain the growth of the follicle in which the egg cell is formed. In addition, it provides endometrial thickening.
In men, this hormone is found in both plasma and serum. During the day, the rate of its production is 30-40 mcg. The main part is formed in peripheral tissues and up to 20% of the total volume is located and is formed in Leydig cells.
The basis of the biochemical reaction of its synthesis is the aromatization of testosterone, which takes place in the presence of aromatase. The activity of this enzyme tends to increase with obesity or with age. Due to the fact that estrogen is a female hormone, with an increase in its level in the body can appear "female" signs.
Norm in men
What should be the norm of this hormone in men in the body? It ranges from 16 to 72 pg / ml or 11.7-41.3 pg / mg, but the figure may differ when decoding analyzes in different laboratories. In addition, the rate can be specified as 70 -105 pmol / l.
Before you visit an endocrinologist, so that he determines the degree of estradiol in the blood, the young man should prepare. For 2-3 days before taking the test, you should refrain from smoking, heavy physical exercise, drinking alcohol and having sex. These factors often change the level of estradiol in men.
Blood is taken from a vein when the patient is hungry. After receiving the results, the doctor deciphers them, sets the level of the hormone in the body and informs the patient about whether his norm is maintained.
The role of the hormone in the body of a man
All hormones are assigned certain functions. The body requires their implementation to maintain homeostasis. Any increase or decrease in hormone levels may cause trouble. In men, estradiol performs the following role:
- responsible for maintaining sexual function
- stimulates hair growth on the head,
- takes part in lipid metabolism,
- provides fertility,
- prevents osteoporosis,
- increases blood clotting.
High estradiol ensures that the male sex hormone testosterone goes down, as they are antagonists. This will lead to the appearance of signs that are not typical for the stronger sex.
Signs of increased estradiol
Reduced, as well as the high level of this hormone brings problems to men. Doctors say: when detecting characteristic dysfunctions in a patient, it is possible to establish a deficiency or excess of this compound. Signs of increased estradiol:
- there is puffiness of the body,
- reduced sexual desire
- lack of muscle growth, even with intensive training,
- the deposition of fat in places characteristic of the female body (waist, hips, chest),
- hair disappears on the face, chest.
Elevated estradiol is hard to miss. There are common reasons for the intensive injection of this hormone into the blood: testicular cancer, obesity, cirrhosis of the liver. An elevated hormone content can develop into hyperestrogenia and gynecomastia. Both diseases are manifested in chronic renal or hepatic failure. But to find out the reason why the norm of the hormone is increased, it is possible only after an exact examination by an endocrinologist.
Estrogen, the rate of which has increased, causes hyperestrogenia. This disease is divided into relative and absolute. Relative is characterized by a decrease in the production of antagonist hormone, that is, testosterone, without increasing the formation of estradiol. Absolute is determined by the actual increase in the concentration of this hormone in the blood.
- malignant tumors,
- reception of the same anabolic steroids,
- renal failure
- liver failure,
- phytoestrogen use (for example, opioid drugs or medicinal plants such as sage, hops, calendula),
- use of household chemicals of any origin.
During treatment, the patient must donate blood for prolactin, estrogen, androgen, thyrotropin, inhibin B. After accurate confirmation of the disease, the doctor prescribes the necessary therapy.
How to reduce estradiol levels
When treating elevated estradiol levels, doctors prescribe the following:
- anti-estrogen drugs
- aromatase inhibitor drugs.
These funds are taken strictly on doctor's prescription. Do not self-medicate.
Anti-estrogens include tamoxifen and clomiphene. They block feedback from the hypothalamus to the pituitary gland. During the period of use of such drugs the norm of the hormones forming estradiol is restored.
Inhibitors inhibit the work of the aromatase enzyme. They can act as antioxidants. Most commonly, Resveratrol, Vitamin C, Zinc, Catechins or Cytadren and Arimidex are prescribed from this group of drugs. Zinc reduces the aromatization of testosterone to estrogen. Vitamin C is often used in the treatment of breast cancer.
The final significance of the excess or deficiency of estradiol has not yet been established. Sometimes deviations from the norm of the hormone are not caused by pathologies and do not lead to them. If a decrease or increase in estradiol causes concern, the man should visit an endocrinologist. This will allow you to keep your usual health and save you from undesirable consequences.
Estradiol increased: why?
An increased level of this steroid is observed in the following pathologies:
• disorders in the functioning of the thyroid gland,
• the presence of cysts or tumors in the ovaries,
• estradiol is elevated in gynecomastia,
In addition, estradiol is enhanced by taking certain medications (for example, anabolic steroids).
The most frequent etiological factor in the growth of the level of this hormone in the body of a man is overweight, impaired testosterone secretion or zinc deficiency, and age-related changes.
Low estradiol: etiology
If we talk about the reasons for the decrease in the concentration of estradiol, then the following etiological factors should be noted:
• disorders in the pituitary gland,
• drastic weight loss,
• chemotherapy for oncopathology.
Normal Estradiol in Men
Despite the fact that the male body is considered to be stronger than the female one, the representatives of the stronger sex also need to closely monitor the hormonal balance.
16-72 pg / ml is the norm of estradiol for men. These indicators were repeatedly confirmed by a number of studies and are considered acceptable.
However, some private laboratories, when issuing test results, note that a normal level of estradiol is 11.7-41.3 pg / mg. This statement is very controversial, so it is better to take into account the decoding of analyzes by a specialist.
Estradiol in men is significantly reduced under the influence of individual factors, therefore, 2-3 days before testing for hormone levels, it is necessary to undergo special training:
- eliminate smoking and intense exercise,
- do not have sex
- do not drink alcohol.
Blood is taken from a vein on an empty stomach.
Symptoms of low estradiol
If all the requirements for the preparatory period are fulfilled, the tests will accurately show whether the blood estradiol norm is met. But to understand that the hormone estradiol is produced in insufficient quantities or in excess, it is possible by individual symptoms.
Low hormone levels lead to inevitable changes in the body:
- osteoporosis development,
- cardiovascular diseases,
- chronic prostatitis,
- problems with conceiving a child, etc.
Experts have speculated why the rate of estradiol in the blood falls.
- The hormone is synthesized in small quantities with regular heavy physical exertion.
- The norm of estradiol falls due to addiction to smoking and vegetarianism.
- The reason for the hormonal imbalance becomes a large amount of carbohydrate food in the diet and lack of fat.
- The hormone ceases to be synthesized due to dysfunction of the pituitary gland.
- The hormone ceases to be synthesized due to endocrine dysfunction.
- Hormonal imbalance can cause severe weight loss.
- Elevated levels of the hormone prolactin triggers a decrease in estradiol.
- Synthesis of a female hormone inhibits medication intake.
Symptoms of elevated estradiol
The rate of estradiol can be significantly exceeded, as evidenced by the following symptoms:
- regular swelling in the body,
- low increase in muscle mass during intensive training,
- decrease in sexual desire,
- the disappearance of facial or chest hair,
- the appearance of fatty deposits characteristic of the female body - in the chest, waist and hips.
The hormone estradiol is intensively released into the blood for many reasons. The most common ones are obesity, cirrhosis and testicular cancer.
Therefore, it is possible to identify the exact reason why the estradiol norm in the body is exceeded, only after a comprehensive examination.
Treatment of hormonal imbalance
When the norm of estradiol in the body of a man is broken, it is imperative to undergo a course of therapy.
If the hormone is produced in excess, anti-estrogen drugs are prescribed by the attending physician. The composition of these drugs include active ingredients tamoxifen and clomiphene, blocking estrogen receptors.
Also, an intensive synthesis of the hormone can be prevented by substances that block the transformation of testosterone into estradiol: anastrozole, letrozole, exemestane, zinc, ascorbic acid, etc.
Estradiol forms the basis of a number of drugs, so the lack of this hormone can be compensated by taking special medications. The list of medications that a man suffering from estradiol imbalance plans to take must be agreed with the attending physician.
Uncontrolled estradiol-based medication in men causes not only hormonal imbalances, but also headaches, liver problems, mood swings and the appearance of excess weight.
Thus, there is a perfectly reasonable need to monitor the level of hormones in the blood. And in the presence of the first alarming symptoms of hormonal imbalance, it is worth contacting a specialist and undergo a comprehensive examination.
Determination of estradiol concentration
In case of hormonal imbalance, the endocrinologist usually recommends donating blood in order to conduct an appropriate laboratory analysis. Estradiol is determined under certain conditions - the analysis is done on an empty stomach. Women need to donate blood for 3-5 days of the cycle. On the eve should limit physical activity. It is also forbidden to smoke or drink alcohol.
The most frequent indications for laboratory diagnosis are irregular menstruation, infertility, uterine bleeding in women, as well as signs of feminization and hypofunction of the sex glands in men. When a low or too high estradiol level is confirmed, the doctor may prescribe an appropriate treatment.
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