IVF and menopause (or IVF during menopause) were recently considered completely incompatible. But modern medicine can work wonders. What was previously difficult to imagine, has now become quite possible. For example, the IVF program for menopause.
In life, it happens that people find their soul mate already at a rather mature age. And sometimes such a couple may want to have their own children. An obstacle to this may be the age of a woman, because it is likely that her body is already in a state of pre- or already menopause.
Fortunately, in our time it is possible to become a mother even in this case - provided that the general condition of the woman’s body allows one to bear and give birth to a child.
Is IVF possible for menopause?
Is IVF possible for menopause? Even if the eggs are no longer mature, it is quite possible to bear the child naturally. IVF for menopause can be performed with the participation of donor oocytes, when the egg is taken from a healthy young donor, fertilized in laboratory conditions with the seminal fluid of the husband and the resulting embryos are transferred into the uterine cavity of a female recipient.
In order for the fertilized egg to attach to the uterus after transplantation, it is necessary to increase the endometrium. This is achieved by taking hormonal drugs as replacement therapy.
Usually, during menopause, estrogens are first prescribed, then they are supplemented with gestagens. Therapy continues after the onset of pregnancy.
Hormonal support is corrected after the placenta formed in the first phase of pregnancy begins to produce its own hormones. But even then many older women may need additional hormonal support.
When can IVF be done
When can I do IVF after menopause? Of course, for women who have reached a certain age, menopause becomes the main obstacle to pregnancy. IVF with menopause can be done if:
- the woman has no medical contraindications to the procedure,
- There are no contraindications for hormone therapy,
- the state of the uterus and the body as a whole allows you to carry out the child independently.
It should be remembered that a woman has no own fertilizable eggs anymore. Therefore, a married couple should be ready to use donor oocytes.
Above were listed only the most basic points at which it is possible to conduct IVF after menopause. A more accurate picture in each case will give a comprehensive examination of a woman's body, based on which the doctor will be able to assess the probability of success of the procedure.
What examinations are required to pass?
Before joining the IVF protocol in menopause, a woman is prescribed a full body examination, based on the results of which the specialists of our clinic will draw conclusions about the possibility or impossibility of carrying out the procedure.
The patient undergoes general clinical blood tests, infection tests, cervical cytology. Be sure to undergo fluorography, mammography, ultrasound of the thyroid gland, ultrasound of the heart, consultations with specialists such as the therapist, oncologist, endocrinologist and other examinations, allowing to exclude contraindications for carrying a pregnancy.
The condition of the uterus is assessed by the fertility specialist by ultrasound, if necessary, hysteroscopy is prescribed.
After reviewing the results of all tests and research, the gynecologist can determine how much a woman’s body is ready to accept embryos.
Do not forget about the future father, who also passes blood tests for infections and semen analysis to determine the quality of seminal fluid and its ability to fertilize.
With unsuccessful IVF
What to do if IVF was unsuccessful?
Based on age alone, it is difficult to predict the likelihood of success with in vitro fertilization. Sometimes, even after 50 years, it is possible to achieve pregnancy, and the woman successfully carries it. In other cases, in 40-45 years, pregnancy does not occur even after several attempts.
If there are contraindications from other organs for carrying a pregnancy or if there is no growth of the endometrium, despite the treatment, then the couple has another opportunity to have a child - surrogate motherhood. The bottom line is that the donor egg is fertilized by the husband's sperm, and then the embryo sits in the womb of another woman. She bears and gives birth to your child.
IVF after artificial menopause
Artificial menopause is the procedure during which the drug stops ovarian function, which leads to the cessation of estrogen production. This technique is often used in the treatment of uterine bleeding, uterine fibroids, endometriosis.
Medical artificial menopause reversible. As soon as the woman stops taking the prescribed drugs, the ovarian function begins to recover, her period is renewed. The duration of a standard course of treatment usually does not exceed six months.
After the end of therapy, both the onset of a natural pregnancy and the procedure of in vitro fertilization are possible.
Is it possible to?
Can a woman after menopause (menopause) do IVF? It is necessary to understand what is meant in this case by natural nurturing and pregnancy. Naturally, after the passage of the last menopause, it is impossible to give birth to a genetically native child, since the eggs cease to mature. And if a woman has not previously saved her genetic material with the help of cryotechnologies, then the birth of a genetically native child is impossible.
However, pregnancy as such is quite possible. But for replanting you will have to use a donor egg from an anonymous or non-anonymous donor. Such an egg cell is fertilized with the help of a donor spermatozoon (also, with the participation of an anonymous or non-anonymous donor). Then, a fertilized egg or a minimally “grown-up” embryo sits in the uterus of a woman who wants to give birth.
If all the procedures of hormonal preparation for pregnancy and all examinations were carried out in full, then it is likely that the embryo will take root, rejection will not happen. That is, normal gestation will occur. This is not uncommon, although the percentage of successful in vitro fertilization procedures among women in reproductive age is higher than in post-menopausal women.
The main task during IVF during menopause is to increase the endometrium in a woman, which will receive an embryo so that it can attach and the gestation passes normally, without rejection. During menopause, the volume of the endometrium is significantly reduced. And it is important to bring it to a normal (for the reproductive phase) thickness for attachment to occur.
For this appointed hormone replacement therapy, which forms an artificial cycle. At its first stage, only estrogen is prescribed. Later, progestogens are also required. After the replanting has occurred and the embryo has adhered, the therapy is continued. Usually, it is carried out throughout the pregnancy.
However, then, in the first phase of a successful pregnancy, the placenta is formed. It also produces hormones, but they are still not enough. Therefore, the initial HRT scheme is adjusted to reflect the new state.
When to do IVF after menopause?
The possibilities of medicine are currently quite large, and a woman can become pregnant after menopause. However, it is not recommended to become pregnant during premenopause due to the unstable hormonal status. Although in such a period, conception can still occur naturally. But if this does not happen for a long time, it is better to consult a doctor. He is an example of a decision when it is better to plan a pregnancy - natural in premenopausal women or using in vitro fertilization, but in postmenopausal women.
In general, a woman after menopause enters a more or less stable, in a hormonal sense, period. However, IVF is recommended as soon as possible. This is explained by the fact that after menopause, the aging process in the body is faster. And the ability to independently carry out a child may disappear, even with successful IVF. In addition, the thickness of the endometrium decreases rapidly, and the more time to wait, the longer it will have to increase.
The procedure is successfully performed when the patient has:
- There are no contraindications for hormone therapy,
- The state of health and the body as a whole allows you to endure the child herself,
- There are no special contraindications for health to the implementation of in vitro fertilization manipulation.
The most accurate conclusion about the likelihood of such a manipulation can be made only after passing a series of surveys and passing several tests.
Usually, it is quite difficult for doctors to predict the success of the procedure, even taking into account the age of the patient. Sometimes in women older than 50 years, the embryo is attached at the first attempt. And sometimes even at the age of 40, the embryo does not survive after repeated repetitive manipulations.
Patients after menopause, as a rule, are not recommended to try repeated IVF, as there is a possibility that the endometrium will not grow during the second stimulation. But in any case, this issue is resolved in a strictly individual manner. In some cases, with good health, the doctor may recommend a repeat IVF procedure.
Anyway, after IVF there is another alternative - surrogate motherhood. With her, a donor egg can be fertilized by a donor spermatozoon familiar to a woman (for example, her husband), and then implanted by a surrogate mother who takes out the child for a couple.
After artificial menopause
If a woman has a menopause after taking hormonal medications, the IVF procedure will be even easier. Drug or artificial menopause is a condition in which the ovaries cease to function as a result of hormonal therapy, and estrogen production ceases.
This is a fairly popular method of treating gynecological formations associated with hormone-dependent tissue growth. For example, this is how uterine fibroids are treated, appearing and growing with a large amount of estrogen. Accordingly, when stopping its production, it resolves.
Such a climax successfully reversible. The use of hormonal drugs of another type stimulates the ovaries, and they begin to work normally. After restoring their functioning, a woman can try to become pregnant herself, or resort to an IVF procedure with the same features as all women of reproductive age.
The cost of this type of service is quite high. It consists of the services of the donor, the cost of drugs, and the manipulation itself.
Is it possible to perform an IVF procedure for menopause?
Fate sometimes gives a person different surprises. Fortunately, they are not always negative. It so happens that people who have already entered into a rather mature age suddenly find each other and decide that they really want common children.
And it happens that the circumstances, the tragedies of life push a woman to the thought of having a baby in menopause. Each story has its own motives, but the desire to give life to a new person always deserves approval and support.
Is IVF possible with menopause at all?
Artificial conception during menostasis
The onset of menopause in terms of anatomy is the process of completion of the reproductive function of the female body. The number of follicles in the ovaries is depleted, there is practically no more menstruation, the eggs gradually cease to mature and the ability to bear children is lost.
Relatively recently, there could be no question of artificial insemination after 45-50 years. But modern reproductive technologies are moving forward by leaps and bounds. And today, the probability of conception in menopause is very real.
Even if natural ovulation is no longer possible - this is not a sentence.
In this case, a formed donor egg is used, which is artificially fertilized with the seed of the partner and placed in the uterus of the potential mother. With the help of accompanying hormone therapy, the body’s ability to bear and give birth to a healthy baby during menopause is maintained.
Conditions for in vitro fertilization during menopause
In vitro fertilization is a serious process that requires careful preparation and analysis of data on the health status of its participants.
Referring to a specialist, you should provide information that may be important for the successful conduct of fertilization (the presence of hereditary diseases, chronic illnesses, surgeries).
If a woman already has children, it is important to tell about the course of pregnancies, the problems, if any, accompanied her.
Based on the received picture, the doctor will be able to decide on the need for additional examination and adjustment of preparatory and supportive drug therapy.
General conditions for artificial conception in the menopausal period are:
- Lack of absolute and relative contraindications. The absolute are the presence of dangerous diseases of the body (HIV, hepatitis, severe diabetes mellitus, the presence of serious cardiac pathologies, oncology of any localization, kidney disease). In this case, we can talk only about attracting a surrogate mother. Relative contraindications include those conditions of the body that can interfere with the proper process of conception in vitro, but do not make it a priori impossible. After eliminating these causes, you can return to the idea of artificial conception. These include infections, endometriosis, tumors of the uterus and appendages, which can be removed using organ-sparing operations, exacerbation of diseases.
- The patient has the possibility of independent childbearing. This should include the absence of congenital or acquired gynecological pathologies, the presence of which physically makes it impossible (removal of the reproductive organs, endocrine diseases in severe form, etc.).
- The absence of contraindications for hormone therapy, because we are talking about a segment of a woman’s life when natural pregnancy and gestation are not envisaged by nature, which means that the hormonal background does not contribute to a healthy natural course of all pregnancy phenomena and requires stimulation from the outside.
Possible fertilization programs
Is it possible to do IVF for a specific patient during menopause, the doctor decides on the basis of history and the current state of the reproductive system. Using the results of the examination, the specialist can suggest to make a certain variant of in vitro fertilization:
- with donor material (sperm),
- with alien eggs,
- banking of your own oocytes,
- use of cryoembryos (were previously frozen).
If you save your own menstrual cycle (premenopause) or artificial menopause, a program of collecting the eggs of a woman for several months is done. If ovulation is not possible, then the only solution is oocyte donation.
Preparation for the procedure during menopause
The procedure of preparing for artificial conception during menopause is in many ways similar to the procedure carried out at reproductive age, but requires an even more responsible approach due to the peculiarities of menopause.
Mandatory studies that are assigned to a woman are:
- general and biochemical blood test,
- general urine analysis,
- infection tests
- blood test for hormones
- cytological examination of the cervix,
- Ultrasound of the thyroid gland, kidneys, adrenal glands, pelvic organs, heart,
- Hysteroscopy may be prescribed to assess the body's ability to embryo.
The following studies are proposed for the future father:
- tests for the detection of infections
- analysis for the determination of blood group and Rh factor.
The stages of fertilization during menopause
After the woman has undergone a comprehensive examination and received the approval of relevant specialists, the next stage begins.
В первую очередь будущей маме назначается заместительная гормональная терапия (ЗГТ). Выравнивание гормонального фона женщины до уровня, позволяющего закрепление эмбриона и его благополучное вынашивание — основополагающий момент успеха экстракорпорального оплодотворения.
But because of some drugs, especially with a long protocol, after IVF, menopause occurs even in women of reproductive age. Therefore, consultations, treatment should be obtained in reliable clinics, where a specialist gives certain guarantees and professionally selects a conception program.
If the organism of the patient planning to motherhood is still capable of ovulation, then HRT makes it possible to carry out the fertilization of the woman’s own eggs. If there is a stable cessation of menstruation, then the only chance may be the use of donor oocytes (eggs).
Eco with donor oocytes includes the following steps:
- Selection of oocyte donor according to certain indicators. These are not only health requirements, but also features of appearance, build and other characteristics.
- Synchronization of the donor and potential mother cycles.
- Stimulation of the maturation of follicles from a donor woman with their subsequent removal.
- Obtaining seed from the father or donor.
- Fertilization of the egg and embryo cultivation.
- Transferring embryos into the uterine cavity with subsequent control over the development process, followed by hormone replacement therapy.
Conception using a woman’s own eggs is of a similar nature, with the exception of the choice of carrier of the source material. In this case, the carrier itself becomes the carrier.
Read about secretions after embryo transfer during IVF by clicking on the link.
Risks and dangers of artificial conception in the period of menostasis
- The embryo may not settle down from the first and even the second time. Naturally, during the period of menopause, roads are every day and month, the loss of time inexorably reduces the chances of a successful completion of the plan. This often becomes a severe psychological stress for a woman who believes and dreams of motherhood.
Since during the procedure several embryos are transferred to the uterine cavity, the risk of multiple pregnancy increases. During menopause, this is highly undesirable, because the chances of success are significantly reduced by increasing the load on the mother's body. In such cases, the reduction is carried out - the separation of embryos that have developed in parallel.
Often this reproductive technology is accused of provoking the development of cancer. Such a risk cannot be denied, especially if there is a predisposition. In babies out of the tube, the percentage of congenital abnormalities is somewhat higher. “Cleft lip”, “cleft palate”, heart defects, and underdevelopment of the esophagus are more common in these children.
For the prevention of serious chromosomal and genetic diseases, a preliminary examination of all participants in the process is carried out, and additional control of the condition of the embryos is carried out before implantation.
IVF with menopause is a rather ambiguous thing.
On the one hand, it is often the only chance to become a mother, on the other hand, the use of this technology is fraught with certain risks. For each case requires an individual approach. Only the joint work of specialists and future parents is able to give the desired result, namely, the emergence of a healthy and strong baby.
Climax is also called menopause. Normally, it occurs in women at the age of 50. After 45 years, the climacteric period begins in the woman's body during which the reproduction of the reproductive function, which is programmed by nature, occurs. In the ovaries, the ovary reserve laid during intrauterine development of the girl is depleted.
These important organs of the reproductive system gradually fall asleep, and the level of sex hormones decreases in the blood: progesterone and estrogen. As a result, the endometrium becomes thinner - the inner layer of the uterus. With the onset of menopause, ovules in women cease to mature, and ovulation ceases.
Therefore, IVF for the ladies who already have a natural climax, is carried out by donor oocytes - oocytes. Oocyte donors are young and healthy women. With the help of a laboratory method, an egg cell is taken from the donor and fertilized by the patient's husband's sperm. The resulting embryo is placed in the patient's uterus.
Early and artificial menopause
If the menopause in the fair sex has come to 45 years, then doctors call her early. As a rule, negative factors lead to such a situation: injuries and brain tumors, radiation exposure, chemotherapy, the influence of toxic substances, severe stresses and hereditary predisposition.
Do IVF with early menopause can be a woman's own ovules. To do this, the patient stimulates ovulation, which allows you to get 1-2 eggs. They are fertilized and injected into the uterus of the ladies. If there is no result from the stimulation procedure, IVF is performed with donor oocytes.
When a woman is diagnosed with endometriosis, uterine myoma or another estrogen-dependent disease, she is prescribed treatment with drugs that suppress the production of sex hormones. This therapy is called artificial menopause. It gives a good result and is widely used.
Indications for IVF procedure
In vitro fertilization is used only in the case when the female organism meets the following requirements:
- There are no absolute contraindications to the procedure.
These include such dangerous diseases: severe diabetes mellitus, serious heart disease, kidney disease, hepatitis, oncological tumors of any localization and HIV. With such diagnoses, it is only about attracting a surrogate mother.
- There are no relative contraindications to the process of egg fertilization.
We are talking about diseases, after treatment, which may be pregnancy. These include: endometriosis, infectious diseases, exacerbations of chronic diseases, as well as neoplasms on the appendages or the uterus, which can be removed surgically, preserving organs.
- There are no contraindications to taking hormonal drugs that need to be taken to stimulate ovulation, endometrial capacity, and after IVF.
- In the uterus, there are no pathological tumors that can interfere with pregnancy: fibroids, fibriomas, etc.
- The physiological state of the uterus and the whole body allows for independent pregnancy.
In order to get answers to all these questions, a specialist will send a woman to undergo a whole range of studies and pass a series of tests.
Even the most "scary" menopause can be defeated at home! Just do not forget two or three times a day.
What examinations are required to pass
Before the doctor signs the necessary package of documents on the procedure of in vitro fertilization with a female, she is obliged to undergo a comprehensive examination, which will confirm that her state of health will allow her to become pregnant and bear the child.
A woman’s examination includes the following tests:
- biochemical and complete blood count,
- blood test for hormones
- a blood test to determine the presence in the body of an infectious pathology,
- general urine analysis.
The test results will allow the reproductologist to assess the health status of the potential patient, as well as her hormonal background.
Mandatory research of future parents
The list of necessary studies for women includes:
- breast mammography,
- Thyroid ultrasound,
- Ultrasound of the kidneys and adrenal glands,
- Ultrasound of the pelvic organs,
- Ultrasound of the heart,
- cytological diagnosis of the cervix.
In some cases, the lady is appointed hysteroscopic examination of the uterus. It is carried out with the help of a hysteroscope - a special medical optical device that looks like a long rod that holds a video camera and lights.
During the procedure, it is possible to examine the entire uterine cavity from the inside in order to assess its condition and ability to receive the embryo.
- sperm analysis for the detection of infections
- a blood test to determine its group and Rh factor.
If the results of the patient's husband's sperm tests show that the probability of fertilization is low, the couple will be offered to use the donor's sperm.
How does the procedure of fertilization
After the couple has undergone a compulsory medical examination and has received the approval of all specialists, a package of documents is signed with her. Then the woman begins to prepare for the procedure of IVF. We consider the situation when the lady of menopausal age and she no longer has a menstrual cycle.
In this case, we can talk about the naturally occurring anovulation - not the maturation of the egg. First of all, she is prescribed hormone replacement therapy in order to even out the hormones. It is necessary to increase the endometrium. A woman is first prescribed estrogen-containing drugs, and then drugs that have gestagens in their composition.
As a rule, women of mature age may require additional hormonal support during pregnancy. It is necessary to strictly adhere to all recommendations of the attending physician, and then the lady will be able to successfully bear and give birth to the child.
Medical statistics show that IVF during menopause allows mature women to independently bear and give birth to a healthy baby. Undoubtedly this is a complex process, which must be approached with all responsibility.
A woman must undergo a comprehensive medical examination. With some serious diseases, this procedure is contraindicated. If the lady is healthy and has no contraindications to IVF, then by fulfilling all the prescriptions of the doctors she can recognize the happiness of motherhood. We wish you good health!
And what do you know about the procedure of in vitro fertilization during menopause?
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Before joining the protocol, you need to make sure if you can do IVF during menopause. To do this, the patient must undergo a comprehensive examination. Although the lack of ovulation is not a direct contraindication to IVF, due to the possibility of using donor oocytes, the health of women plays a fundamental role.
With age, the woman's health deteriorates, and various chronic diseases often appear that can interfere with normal pregnancy. To identify pathologies, a woman takes the following tests:
- laboratory blood tests for infections,
- urine tests
- urethral, vaginal and cervical smears,
- Pelvic ultrasound,
- Thyroid ultrasound,
In addition to the examination, the patient will need to visit an oncologist, endocrinologist, therapist, psychologist, cardiologist. The exact list of instrumental studies and narrow specialists to the patient will be announced by the reproductive specialist. If there is no indication for hysteroscopy and laparoscopy, then the procedure is most likely not prescribed.
According to the results of the examination, a woman should not have hormonal disorders, obstacles to the natural bearing of the fetus. It should be understood that IVF with menopause will require hormone therapy. If you take hormones for serious disorders in the body, you can provoke serious complications.
IVF for menopause is different from conventional IVF in which eggs will be used for fertilization. If a woman planned IVF at a later age, then she could donate the eggs in advance and save them using cryopreservation. In this case, the patient's frozen eggs will be used for the procedure.
If the patient has not taken care of the eggs in advance, then IVF will be possible only with donor oocytes. After menopause, a woman does not mature follicles and ovulation, so it’s impossible to obtain a native egg cell.
IVF for menopause without menstruation is performed using hormone therapy. This is necessary in order to provoke the growth of the endometrium and to prepare the uterus for implantation and bearing the fetus.
If the patient has an early menopause before the age of 45, then there is a small chance to get her egg cell and try IVF with her. For this purpose, stimulation of ovulation with hormonal drugs is prescribed.
With artificial menopause, when menstruation is absent while taking hormonal drugs, it is also possible IVF with its eggs. In this case, the drugs are canceled, and the woman is prescribed treatment to stimulate ovulation. After stimulation, oocytes are taken from the follicles by puncture and fertilized.
The big disadvantage of IVF after menopause is that the woman will have to pay for the whole process from her own pocket. The fact is that under the OMS policy, only patients of reproductive age up to 38 years old can undergo the procedure. Given that the effectiveness of the procedure after 40 years is quite small, IVF with menopause can cost a lot of money.
Accurately talking about the effectiveness of IVF during menopause is quite difficult. According to statistics, pregnancy after 40 years occurs only in 10% of cases. But there are many women who give birth after 45, and even at the age of 50, after one or two IVF attempts.
An important aspect here is which egg cell will be used for fertilization. If IVF with menopause will do with an egg cell of a young and healthy female donor, then the probability of success is much higher. The fact is that with age, the quality of oocytes deteriorates, and freezing affects them not in the best way, all the weak die.
If ten-year-old oocytes are used for fertilization, or a single egg that could be obtained by stimulating ovulation, then the chances will be very small.
Delivery after IVF with menopause is a very crucial moment. Women over 40 always give birth by caesarean section, especially after IVF. This is due to age-related changes in the body that interfere with normal natural childbirth.
IVF for menopause is a complex and responsible process that requires high professionalism of doctors, high costs and readiness of a woman. But the most important thing is that menopause is not an obstacle to a happy pregnancy and the birth of a healthy, and most importantly beloved baby.
1. IVF with donor oocytes.
- selection from the oocyte donor database (you can get acquainted with the database in the section DONATION, FOR PATIENTS or send a request to our managers by e-mail).
- The choice is made in accordance with the phenotypic characteristics of the recipient, her blood group and Rh factor.
- Discussion with the attending physician of the start date of the program.
- Preparing the patient according to the scheme prescribed by the doctor.
- Stimulation of the donor in the case of the native cycle of preparation of the donor or coordination with the embryologists of the clinic for the preparation of vitrified oocytes of the selected donor.
- Fertilization with the sperm of the husband or partner of the recipient oocyte donor.
- Embryo transfer to the uterus of a woman.
3. The program of banking own oocytes for women with reduced ovarian reserve.
Possible for women who still produce their own eggs. Thus, IVF with menopause is possible! However, it should be understood that adult pregnancy is far from being shown to everyone; therefore, obstetricians and gynecologists and reproduction specialists pay special attention to the preparation of such women for the program and in some cases refuse to prepare such patients.
Important factors are:
- The condition of the uterus of the patient, the absence of tumors such as fibroids, fibroids and other pathologies that are often encountered at this age.
- General condition of the body. Consultation of the therapist is necessary for any woman, but in the case of the IVF program for menopause, our therapists pay special attention to such patients.
- Socio-economic aspects of the problem. It is clear that it is important not only to give birth and bear, but also to bring up the born child. In many clinics there is an age limit for IVF programs. It is usually 55-57 years old.
Manifestations of menopause
At the age of 45-55 years in the female body changes occur:
- ovarian function decreases,
- decreases the amount of estrogen
- the endometrium is gradually thinning,
- ovulation stops, the eggs do not mature.
Hypoestrogenism affects many organs:
- wrinkles appear
- skin becomes dry
- production of mucus in the vagina decreases,
- bones become thinner
- easier to gain excess weight.
Under the hormonal influence get the cardiovascular, nervous, endocrine systems. There is increased pressure, nervousness, problems with the thyroid gland. So the climax is shown.
When can I resort to IVF during menopause?
If a woman has entered the period of menopause, but wants to have a child, the only way to achieve the desired is to resort to IVF. Однако одного желания недостаточно, нужно соответствовать некоторым требованиям:
- Нет тяжелых болезней внутренних органов, являющихся противопоказанием для беременности.
- Состояние матки позволит развиться плоду, нет опухолей, миомы, изменения формы.
- Отсутствуют противопоказания для гормонального лечения.
In each case, the decision on the possibility of IVF with menopause after 50 years is taken individually.
IVF with menopause
In order to prepare the uterus for IVF with menopause without menstruation, hormone replacement therapy is prescribed. For this, estrogens are used with the additional introduction of gestagens into the second phase. Assessment of the state of the endometrium is performed using ultrasound. Optimum thickness from 7 mm.
It should be remembered that with the onset of menopause, their own eggs cease to mature, therefore IVF is performed by donor oocytes. The exception is women who have cryopreserved their own cells. In some cases, it will be recommended to use donor sperm if the quality of the cells of the spouse turns out to be doubtful.
After successful implantation of the embryo, hormone replacement therapy is continued until the formation of the placenta. She later assumes the hormonal function of maintaining pregnancy.
Use of donor egg
As a donor can be used fresh or frozen egg.
The use of such an oocyte is safe enough:
- All donors are screened for infectious diseases (HIV, syphilis, hepatitis), severe chronic diseases, and hereditary pathology.
- We study the working conditions and occupational hazards.
- The donor is selected from among non-smokers who do not use alcohol, drugs, and also harmful medications.
- The health status of the donor children is taken into account.
Future parents may prefer a certain appearance, eye color, donor's hair. Sometimes in order to maximize the similarity of his chosen from among close relatives.
Causes of unsuccessful IVF
A thorough examination of future parents does not protect against failures. Failure of IVF can lead to:
- overweight and endocrine diseases of the expectant mother,
- insufficient thickness of the endometrium,
- genetic damage that occurs after fertilization and prevent the development of pregnancy,
- pathology of the immune system
- non-compliance with the recommendations of the doctor.
High-quality preparation for the future pregnancy of a woman after menopause and the use of the genetic material of a young donor increases the chances of success of becoming a mother.
Yulia Shevchenko, obstetrician-gynecologist, especially for Mirmam.pro
How to get pregnant with menopause: the answer of the expert doctor
Nature limited the woman to a rigid framework, and gave her an age for the birth of offspring on average from 20 to 40 years. Many representatives of the fair sex do not agree with this, and believe that a woman has the right to have a child when she wants, and not in the time allotted by nature.
And, for various reasons, they postpone motherhood. Some prefer to pursue a career without a break for children, others - have not met a worthy partner, the third - an unstable financial situation. And it happens that a woman simply can not get pregnant and is treated for a long time for infertility.
But, anyway, she didn’t have time to look back, as she celebrated her 50th anniversary and was in premenopause. Ambient whispering that the train was gone. And, a woman runs to the doctor to figure out how to get pregnant during menopause? Is there any chance? Is it possible to do IVF during menopause?
We hurry to reassure the lovely ladies - pregnancy during menopause in our time is not a myth, but a reality. Although maternity in the age of menopause, which is assisted by assisted reproductive technologies, causes a lot of controversy, both in the medical and in the public environment.
Desired pregnancy with menopause
How to be those women who want to become a mother in a more mature age, for example, after 50 years? And is it possible to hope to get pregnant naturally, if the future mom, to put it mildly, for quite a few years?
The problem of postponed maternity in recent decades is very relevant. Unfortunately, by the time the woman took place professionally and socially, and finally decided to become a mother, natural fertility begins to decline. There is a scientific explanation for this:
A girl is born with a certain number of eggs. During the neonatal period, it has 1.5 million immature eggs. By the period of puberty, there are about 400 thousand.
For the entire period of childbearing, only 400 eggs mature in a woman. And the rest are subjected to atresia and die. By the age of 40 years, the rate of consumption of follicles increases.
It is this age that is considered critical to reproduce offspring. And the probability of pregnancy is sharply reduced.
The quality of oocytes (immature eggs) decreases, which leads to an increase in chromosomal and gene abnormalities.
On a note!
Conducted studies have shown that in women aged 42 years, every second egg is pathological. By age 45, each female sex cell contains chromosomal abnormalities. Accordingly, these eggs can not give a full-fledged embryo and a healthy baby.
The presence of the female reproductive system pathology in this age group: uterine fibroids, endometriosis, uterine cavity polyps, inflammatory diseases. Somatic pathology is also important - diabetes mellitus, hypertension, obesity.
Frequently asked reproductologist questions:
- "How to get pregnant after menopause?"
- “Menopause has come, and I want to give birth, how quickly can I get pregnant?”
Such women need to clearly understand that the onset of menopause means the absence of ovulation. And quick pregnancy here will not work. In this case, when ovarian stimulation in the IVF program at the age of 50, two difficulties can be encountered:
- get a very small number of eggs (from 1 to 4),
- There is a high probability that chromosomal pathology will be revealed in this small number of cells.
Is there really no way out? There is. "Age" patients can offer donor eggs taken from young women. But here the moral aspect comes to the fore - not all women are ready to bear genetically alien material.
It is important not to lose time !!
By the age of 45-50, the follicular reserve is exhausted, ovulation during menopause happens less and less, irreversible switching off of the reproductive function of the ovaries occurs, and the chances of conception during menopause are almost zero.
Today's advances in medicine are such that everyone can give birth, and even in old age. But every woman should understand that her stock of eggs in life is not infinite.
And that every year the number of germ cells only decreases. And if the issue of childbirth is still open and the woman is not ready to become a mother at a younger age, then there is always the possibility to stock up the egg for "beloved."
And this should be done as early as possible, until the oocyte reserves are depleted.
Cryopreservation of eggs
Today, reproductive technologies allow to determine the number of eggs in the female body, to stimulate their production in the ovary, under the control of ultrasound to pick up and freeze them for several years, until a woman decides to become a mother.
In Russia, freezing eggs (cryopreservation) is not yet as popular and in demand as in the whole world. Abroad, women use this service not only when they want to postpone motherhood for some time, but also in case of cancer, before chemotherapy, which almost destroys fertility.
Medicine has a case in which a young Japanese woman has frozen her eggs before chemotherapy. And she took advantage of her biological material only 13 years later, and safely gave birth to a healthy baby at the age of 47 years.
Until recently, Russian laws prohibited the use of assisted reproductive technologies for women who had previously had cancer and recovered. And today there is already evidence that one of the Russians, after suffering cancer, is preparing to become a mother at the age of 49 years. In August 2017, she was given an IVF procedure and two embryos were planted.
EKO: what is more suitable for menopause?
There is an opinion that it is impossible to get pregnant and carry a child into menopause. And what about those who, hypothetically, have already matured for motherhood, but did not manage to do it in time? Can a woman give birth during menopause? Yes maybe.
Only you need to understand that the chances of conceiving a heir in a natural way are significantly reduced. But do not despair.
Today, reproductive technologies allow you to have children to everyone, regardless of age, no matter how fantastic it sounds.
Often women ask the question whether IVF is possible during menopause, and how effective IVF is during menopause? Positive results are undoubtedly possible at this age. However, their effectiveness is lower than, say, in patients up to 35 years. The low effectiveness of the IVF program after menopause is due to two main reasons:
- a decrease in ovarian reserve,
- and the deterioration of the quality of the eggs.
There are two ways for “age-related” patients who apply to the reproductive center:
Get your pregnancy with ART, but the chance to get pregnant in this case does not exceed 5% for one IVF attempt during menopause,
Increase the chance of success, and conduct IVF with donor oocytes. In this case, the donor's egg cell is fertilized by the sperm of the husband or the alleged father of the child, and the embryo is transferred into the patient's uterus.
How many chances of pregnancy after 50 years
From a medical point of view, conception in a woman can occur only if there are functioning ovaries, in which a full-fledged egg cell, ready for fertilization, develops. The opportunity to conceive a child for a woman without the use of medical technology is rapidly falling after 45 years, but the probability of giving birth to a not very healthy baby, on the contrary, increases significantly.
No, there are, of course, happy cases of spontaneous conception and even safe delivery. And you can cite many examples of "menopausal women who gave birth" to women. Here are the most famous "age" mothers in the world:
- Brazilian actress Solange Couto presented her second husband with a second husband at the age of 54, before that she was already the mother of two children,
- Russian woman Natalya Surkova, having two adult sons from her first marriage, gave birth to a daughter at the age of 57, a new spouse who did not have children.
But still, most of these unique pregnancies in later years are not God's business, but the result of in vitro fertilization. About this often appear in the press, especially if they relate to famous personalities.
So, a vivid example of the conception of children in adulthood with Russian diva Alla Pugacheva and artist Maxim Galkin is in-vitro fertilization with frozen eggs (which the singer took care of in time), and replanting them for carrying a surrogate mother.
Kids turned out wonderful!
What examinations are necessary for passing, that IVF in a menopause passed successfully
In order for the IVF procedure for menopause to be successful, the following analyzes will be needed by the fertility specialist:
- Ultrasound of the small pelvis (it is necessary to know the number of follicles in the ovaries and to assess the condition of the endometrium, to exclude the pathology of the uterus).
- Indicators of the hormonal status (blood on FSH, LH, estradiol, testosterone, antimullers hormone, inhibin, thyroid hormones - TSH and T4), they need to take for 2-3 days of the menstrual cycle.
According to the results of the hormonal status data, the doctor will assess the state of your ovarian reserve and decide whether to use the IVF program for menopause with your oocytes or to resort to donor oocytes.
- A smear from the cervix to detect cancer cells in order to detect early malignant processes. If you identify the initial signs of "cancer degeneration" of cells, the IVF procedure for menopause will have to be postponed.
- Spermogram husband or potential father of the child. This analysis shows the quantity and quality of sperm, eliminates the factor of male infertility. When the latter is detected, IVF after menopause is performed with donor sperm.
- Blood tests for HIV infection, syphilis, hepatitis B and C are mandatory.
- Examinations for infectious diseases, including those that are sexually transmitted.
Every woman has her own way to motherhood. Someone decides to give birth to the baby after the tragedy with the older children, someone breaks into life a new love, and someone finally managed to recover from infertility. And today's reproductive technologies are able to help them find the joy of motherhood.
obstetrician gynecologist Ivanchenko Oksana Viktorovna
Pregnancy after 50 years with menopause
Pregnancy is a joy for almost any woman. However, if a woman is no longer young, has any illness or lack of strength, then pregnancy can be a real challenge.
Pregnancy after 50 years with menopause is considered a myth, some women do not believe in this fact. But with some frequency such cases occur. In this article, any woman will be able to learn about the possibilities, the dangers of such a late pregnancy, as well as what advantages should be identified from this.
After 50 years, almost all women have menopause. Menopause is the period in the life of every woman during which her reproductive function decreases. During this period, pregnancy occurs much less frequently than at a younger age. Let's analyze the stages of menopause:
- Stage premenopause. This period begins to 5-7 years before this menopause. At this point, the woman notices that her menstrual cycle is changing. The menstruation becomes not so plentiful and long, and the period between two periods only increases. This is due to the weakening of ovarian function.
- Stage of menopause. This period comes after the last menstruation. It lasts about a year.
- Postmenopausal stage. This stage is the final stage of menopause. He will accompany the woman to the end of her life.
Pregnancy after 50 years is most often unexpected, as the woman believes that you can not get pregnant. However, it is not.
When a girl is born, she has an estimated number of eggs equal to 400,000. After 50 years, the woman still has about a thousand eggs, so that pregnancy is possible.
A woman in menopause has a decrease in ovarian function. This is due to a decrease in estrogen production. A woman after the age of 50 must still use contraceptives for 5 years.
Reasons for conception
Recently, not only around the world, but also in Russia, pregnancies after 50 years are increasingly occurring. There are certain reasons for this.
- Pregnancy occurs precisely at this age, as a woman could not get pregnant all her life. In this case, the woman goes on a desperate step in order to continue her race. Pregnancy is created consciously, with the understanding of all possible problems.
- Pregnancy after 50 years is due to give a new husband a child. The woman understands that the child is able to strengthen the bonds of marriage, to bond the relationship, as any man, in the first place, will be happy just for her child, and not for someone else. Pregnancy occurs consciously.
- But still most often pregnancy after 50 years is a surprise for a woman. This is due to the ignorance of the female reproductive system. Such a pregnancy is often undesired and leads to many problems.
Even after 50 years, a woman must understand the seriousness of the situation. Even before the onset of menopause, you must decide whether it will give birth yet. If not, then it is necessary to be protected as long as the gynecologist speaks.
If a woman becomes pregnant after 50 years, then she should be aware that the physiological youth is coming to an end. The whole body is not working as well and smoothly as before. Therefore, there are certain risks that are presented below:
- Loss of strength and deterioration of physical condition during pregnancy.
The body can no longer bear a child, as before, it is much harder for him. If a woman had a previous pregnancy well, then pregnancy after 50 years is always a test. A woman will be tormented by a strong toxicosis, she will have no energy even for the most basic things that she has done without problems before.
There is insomnia, which leads to the appearance of headaches. When a child is born, it requires a lot of attention from the mother, which is hard to care for her child, even if she tries to do it.
- The manifestation of chronic diseases.
If a woman before pregnancy had chronic diseases in remission, then they will definitely worsen during pregnancy. Because of this, both the woman and the child suffer. Therefore, if such a late pregnancy is planned, then you should consult with your doctor in order to exclude exacerbations of chronic diseases.
- The emergence of new diseases.
Since during pregnancy a woman’s body should work for two, sometimes he doesn’t cope with it.
By the age of 50, a woman's heart, kidneys and other internal organs weaken, it is incredibly hard for them to work for two, which is why inflammatory processes in the kidneys occur, heart work worsens, etc.
И так уже слабые кости и зубы становятся еще менее крепкими. Из-за этого женщина вынуждена посещать не только гинеколога, но и многих других врачей.
- The appearance of gynecological diseases after childbirth.
Due to the fact that the uterus can no longer recover as before, immediately after birth there is a great risk of infection and inflammation.
In some cases, pregnancy is normal, but such cases are few. Most often, pregnancy is not severe if the woman in the family has late women who have given birth, or if the woman has a healthy body.
As it turned out, not only the woman, but also the child itself can suffer from late childbirth. When he is still in the womb, he receives far less nutrients than he would have received in a normal pregnancy. Because of this, he has health problems.
Virtually every 10 children who were born to a 50 year old mother has deviations in their physical and mental development. In some cases, children are generally born with serious pathologies and become disabled as a result.
When the child is not yet born, he feels perfectly the condition of his mother. And since the woman is in constant stress due to newly begun diseases, due to fatigue or fear, the child takes all the blows on himself. Such children in some cases are born with a problem psyche. They may cry longer than other children or vice versa, be slowed down and lethargic.
In the event that a child is born healthy, he may still experience constant stress. For many children, it is important that their parents are young, beautiful and still full of energy. When the mother of the child crossed the 50th summer threshold, then the child may be ashamed to go out with her in public, to show it to her friends. In some societies, these children are mocked and bullied.
Because of the constant constraint, the child does not open up completely to his parents, he has secrets, he tries to communicate less with his parents. Therefore, when such a child has problems, he has no one to turn to for help, since he has not built a relationship of trust with his parents.
When parents are no longer young, they are unlikely to be able to put the child on their feet, since they no longer have the same strength and energy as before.
They are more worried about their health problems. Therefore, as practice shows, if a child has strongly adult parents, then he will have to achieve everything in life on his own.
On the one hand, it has a plus, and on the other hand - a minus.
It often happens that a woman gives birth to a child at a young age, but she has no experience. Because of the inept actions of the parents, the child suffers in the first place, since, for example, he may not be given timely help.
Therefore, if a woman gives birth at the age of 50, then it means that she has the greatest experience and knowledge behind her back, which is inaccessible to younger women. Because of this, a woman is able to help the child in time, if necessary. She is not as worried as a young mother, she does everything correctly and rationally.
Women who have a menopause, in some cases, feel anguish and frequent mood changes, as they begin to realize that youth has already passed. Pregnancy, if desired, can bring bright colors to family life, improve the relationship between spouses. After giving birth, a woman forgets about some of her problems, as she concentrates more on the child.
From this we can conclude that even in late pregnancy there are positive sides. But do not forget about the negative.
Eco with menopause
Eco procedure for menopause and the absence of ovulation is possible, since in this case donor oocytes are used. But before going through this procedure, a woman needs to resolve this issue with a gynecologist.
The gynecologist will not be able to give an accurate answer until the woman has all the necessary tests. She needs to donate blood to detect infectious diseases, urine, smears of the urethra and vagina.
In addition, you need to undergo ultrasound of the pelvic organs, in order to exclude any disease. A woman’s mammary glands are also being examined for the detection of tumors or cancer, and fluorography is performed.
In some cases, you have to use laparoscopy - surgery, in order for the doctor to be able to visually verify the patient's health.
If all these items do not have abnormalities, then the pregnancy will be able to occur, and the doctor gives his consent.
But the woman is obliged to visit a neurologist, oncologist, dentist, cardiologist. If something does not work as it should, then the woman is prescribed a course of medicines that will improve her condition.
IVF is carried out using donor eggs or their frozen. Most often still used donor. IVF at this age is done with the help of hormone therapy. Due to this, the uterus becomes ready and elastic for making pregnancy.
If conventional IVF can be free for women of reproductive age, then during menopause, she will pay for the entire procedure on her own. IVF is quite expensive, but it has a good positive effect. In order to simply become pregnant independently, a woman may need about 10-15 attempts, and a positive effect from IVF occurs already 1 or 2 times.
The effect of IVF still depends on the age of the egg that was used. The younger the woman was, from which the egg was taken, the greater the chance of a successful conception.
the difficulty lies in the fact that a woman cannot give birth in a natural way. Her uterus will not cause such reductions and attempts as before. Therefore, all genera are only artificially, with a caesarean section.
On the one hand, this facilitates the role of a woman, and on the other hand, a woman after 50 years will recover for a long time after such a procedure. An ordinary young woman recovers after a cesarean section for about 3-4 months; for a woman after 50, recovery will take at least six months.
There is a certain risk of infection in the uterus or peritoneum, since the body will no longer be so diligent to deal with microbes.
After childbirth, a woman will still have a long bleeding time, which can lead to many diseases, such as anemia. After late delivery, you should be constantly monitored by doctors, in order to prevent complications.
Pregnancy after 50 years is a crucial decision. It is impossible to forbid a woman to do this, as there are cases when it is really necessary for a woman. However, in other cases it is worth taking care of your contraception and not allowing this kind of pregnancy, especially if the woman already has children, as there are a large number of disadvantages.
A woman should not make this kind of decision on her own; she should always consult with a doctor and her partner. After all, from such a decision will depend not only the health of the woman, but also the health and future life of the child.
Nuances of IVF with menopause
In recent years, the childbearing period has become longer: now they give birth not only at 25, but also after 45. Despite the extinction of the reproductive system, many people decide on IVF during menopause, because this is the only possible way to have a baby in the postmenstrual period.
In vitro fertilization is resorted to when, due to hormonal changes in the ovaries, an egg cell is not produced, and the probability of conception tends to zero. Menopause is not a reason to refuse a decision to have a child, because modern medicine allows a woman to become a mother even after 50 years.
When planning to do IVF during menopause, it is important to undergo a diagnosis in order to determine the body’s readiness to perform such an intervention.. A woman undergoes a complete medical examination, because her body must meet the following requirements:
- The absence of contraindications to artificial insemination.
- Inability to self-conceive a child.
- The absence of contraindications to hormone therapy during the preparation for fertilization. If the body has already rebuilt to the new working conditions, when there was a complete extinction of the ovaries due to age-related changes, the course of pregnancy becomes impossible without complications.
At the survey stage, the following tests are performed for IVF:
- blood and urine test
- Pelvic ultrasound,
- Thyroid ultrasound,
According to the results of a complete examination of the body, a woman of menopausal age should not have a hormonal imbalance that prevents a healthy pregnancy.
Preparing for IVF with a donor egg
IVF with menopause in the absence of ovulation and the impossibility of its hormonal stimulation is available with the help of donor eggs. If in vitro fertilization with menopause becomes possible only with the help of a donor, the procedure can be carried out in two ways:
- frozen oocytes are used when material is taken from a donor bank,
- fertilization of the newly obtained egg with the sperm of a husband or donor.
The first version of the operation is cheaper, but the probability of success is 10% lower than that of the second method.
The important moment of preparation for fertilization is the choice of the candidate for donation of her egg. Two options are possible:
- Spouses independently choose a female donor among acquaintances or close relatives. If this is not possible, the clinic can offer candidates from the existing list of donors, guided by the wishes of the married couple.
- Anonymous. In this case, the spouses do not know the donor, they only describe the intended portrait of the woman, specify the blood group and the Rh factor.
Further, the examination and stimulation of donor superovulation for the maturation of several eggs is carried out.
In order for the fertilized egg to attach to the wall of the uterus, the potential mother is prescribed drugs to increase the endometrium of the required thickness - 8-10 mm. For this therapy is applied hormonal drugs. Appointed:
If the body is in deep menopause, even with the help of hormonal means it is not always possible to revitalize the endometrium.
Before planning the birth of a child in menopausal age, a woman can donate her eggs and save them in the laboratory by cryopreservation. In this case, there is no need to resort to the use of donor embryos for IVF during menopause.
Contraindications for IVF
It is not always possible to conduct this procedure, it has contraindications, they are divided into absolute and relative. The first group includes the following serious pathological processes:
- heart pathologies,
- severe diabetes mellitus
- oncological diseases,
- kidney disease.
Relative contraindications are conditions of the body that constitute an obstacle to the normal course of pregnancy. These are hormonal disorders, endometriosis, genital infections and other symptoms. After their removal, you can resort to fertilization.
How does the embryo graft procedure work?
After conducting a survey and obtaining approval from all specialists, you can proceed to the procedure of in vitro fertilization.
If the body is still capable of producing an egg, treatment is carried out by stimulating ovulation with hormonal drugs.
With a stable absence of menstruation, IVF with a donor egg cell becomes the only method of treating infertility.. The procedure consists of the following stages:
- Choosing a donor.
- Stimulation of the maturation of donor follicles and their removal.
- Seeding from a husband or donor.
- Artificial insemination of the egg.
- Embryo placement in the mother’s womb.
After a successful IVF procedure, the woman is under the supervision of a specialist for the entire period of gestation.
As a result of IVF children, more than one is sometimes born. Multiple pregnancy develops due to the fact that several embryos are transferred to the uterus at the same time. However, during menopause, this is undesirable, because the load on the weakened body of a woman is increasing, which may affect the health of children.
Concerning artificial insemination with menopause, the views of specialists are ambiguous. On the one hand, the method gives a woman a chance for motherhood at a later age, but on the other, it can be accompanied by many risks and possible complications.
Features of IVF for menopause
Is it possible to do IVF during menopause, what is the probability of successful conception and childbirth? The decision to conduct the procedure is made by the reproductologist, based on the absence of contraindications, the results of laboratory and instrumental studies. While maintaining the menstrual cycle (perimenopause) or artificial menopause, viable eggs are harvested for several months. Then fertilized embryos are placed in the uterus of the recipient, after preparatory hormonal therapy.
If oocyte maturation does not occur, use donor biomaterial or own embryos harvested earlier. Apply only sex cells that have been in a frozen state for no more than 10 years. The probability of a successful conception with the use of cryoembryos is much lower than when replanting fresh donor eggs taken from a healthy woman.
Indications for artificial insemination
The IVF procedure for menopause with donor eggs is recommended in the following cases:
- premature ovarian exhaustion syndrome,
- congenital pathologies of the ovaries, uterus,
- age over 35 years
- polycystic ovary syndrome,
- genetic diseases in history
- unsuccessful attempts at artificial insemination due to the poor quality of oocytes,
- previously removed ovaries, appendages.
IVF with menopause is not carried out in the absence of the uterus, with viral, infectious diseases of the urogenital tract, tuberculosis. The procedure is not prescribed to women suffering from arterial hypertension, chronic renal, hepatic failure, cancer, thyroid abnormalities, aplastic anemia. The absolute contraindications include a ban on hormone therapy, cancer of the uterus, ovaries.
Types of examinations in preparation for fertilization
To do IVF, prospective parents must undergo a full medical examination. Women visit a gynecologist, fertility specialist, therapist and psychiatrist. If there is a hereditary disease in the patient’s or her husband’s history, relatives with congenital malformations are referred to a genetics consultation. Carry out karyotyping (study of chromosomal apparatus).
In the absence of contraindications to IVF, a satisfactory state of health of the recipient, the doctor assesses the success of the procedure, gives an opinion on the permission or prohibition to perform artificial insemination. In the case of exacerbation of systemic diseases, it is recommended to undergo a full course of treatment and rehabilitation before embryo transfer.
Mandatory research for future parents
The list of analyzes in preparation for artificial insemination:
- biochemical, clinical blood and urine tests,
- research into hidden infectious diseases,
- blood test for Rh factor
- Ultrasound of the pelvic organs, thyroid gland,
- analysis of the level of sex hormones,
- cytology of the cervix,
- bacteriological examination of the cervical canal,
- smear on the vaginal microflora,
- test for HIV infection, syphilis, hepatitis B, C,
According to the testimony, a woman can be sent to test for the level of thyroid hormone levels, determine the concentration of sugar in the blood, immunological tests, kidney, liver function tests. To assess the state of the endometrium of the uterus, colposcopy, microscopy, and hysteroscopy of the reproductive organ are performed.
For successful IVF make spermogram of seminal fluid of the husband, it allows you to assess the degree of sperm motility. A man must also undergo research on urogenital infections, pass bacteriological analysis of sperm on the bacterial flora, visit the andrologist. If parents suffer from systemic diseases of internal organs, consultation of relevant specialists is required.
How is the procedure of fertilization
IVF with menopause and no ovulation is performed using donor oocytes. For this, eggs are taken from a healthy female donor, then the biomaterial is fertilized by the sperm of the future father in the laboratory. For the purpose of conception, they use their own, previously vitrified, oocytes of close relatives or germ cells from the cryobank of the clinic.
An embryo grown in an incubator is placed in the prepared uterus of the recipient. If the endometrial layer is insufficient (less than 7 mm), hormone therapy with estrogen and gestagens is carried out in advance. HRT continues throughout the first trimester of pregnancy while the placenta is being formed. This avoids the rejection of the embryo. Therapy is prescribed individually for each patient and is carried out under the strict supervision of a physician. После 14-й недели гестации начинается выработка собственных гормонов, необходимых для нормального вынашивания ребенка и ЗГТ прекращают.
When using fresh oocytes, the preparation of the donor and the recipient is carried out simultaneously, synchronize the menstrual cycles, stimulate ovulation and perform the collection of eggs. Fertilization is done in vitro, after which the embryo is placed in an incubator for 3–5 days. On days 17–18 of the cycle, the embryo is transferred to the uterine cavity. The whole process of pregnancy takes place under the supervision of a physician.
Is it possible to do IVF during menopause?
More recently, it was thought that menopause and pregnancy are absolutely incompatible things. However, modern medicine has made great strides forward, and today a woman even in the period of menopause is able to conceive and give birth to a child with the help of assisted reproductive technologies, namely IVF. The fact that a few years ago was impossible - nowadays is quite real.
It often happens that a woman meets her life partner when her reproductive function has already faded. In this case, if the partners have a desire to have a baby, assistive methods of conception come to the rescue. Often, the age of a woman can interfere with conceiving a child in a natural way, but with the help of the method of in vitro fertilization, the dream may well become a happy reality.
How to conceive a child in menopause?
At a time when the egg cells are no longer produced in the female body, the possibility of gestation still remains. Such a probability is present if, instead of using our own oocytes, we resort to using donor material. In this case, the conception takes place in the laboratory, with the participation of donor spermatozoa or spermatozoa of the woman’s partner, after which the embryos are planted in the body of the expectant mother, thereby enabling further normal development of a full-fledged pregnancy.
Ask a question to a reproductologist
In order to increase the chances of successful implantation, a woman who wants to get pregnant using IVF during menopause is prescribed a course of hormonal drugs that contribute to the growth of the endometrium. As a rule, with the onset of menopause, a woman takes estrogen, after which the hormonal course is supplemented with gestagens. After establishing the fact of implantation, the patient is obliged to continue to take appropriate medications for some time so that the pregnancy can proceed without complications.
Important! After the placenta begins to fully perform its functions, reproducing its own hormones, drugs can be gradually canceled. As a rule, this occurs in the first trimester of pregnancy. Some patients do not cancel the drugs until the moment of delivery - each case is individual and the need for further medication is determined only by the doctor.
Who is indicated for IVF during menopause
The effectiveness of IVF in the onset of menopause also depends on a number of concomitant factors, including the general health of the patient. Menopause itself is not at all considered a contraindication to the onset of a normal pregnancy. For IVF with menopause, you can resort in the following cases:
- in the absence of other contraindications to the IVF procedure,
- with satisfactory health and body of the expectant mother,
- If taking special hormonal drugs for stimulation is not contraindicated for a woman.
These are only the basic conditions that allow for effective IVF in the period of menopause. The success of the procedure and the feasibility of its implementation can be predicted only by the attending physician, on the basis of various analyzes and tests.
Make an appointment with a fertility specialist
Important! Future parents should be aware that since the woman has no own eggs in the body during the period of menopause, deciding on IVF will have to resort to using donor biomaterial.
Preparing for IVF with menopause
Like a young patient, and a patient with menopause and her partner (if there is one), it is necessary to undergo a thorough preparation before the in vitro fertilization procedure and pass a series of special tests based on which the attending doctor will be able to judge the possibility or impossibility of IVF. These analyzes primarily include:
- general blood analysis,
- analysis for various infections
- examination of the state of the cervix,
- Ultrasound of the mammary glands, heart, thyroid gland.
In addition, the patient is prescribed referrals for consultation with an endocrinologist, oncologist, therapist. In some cases, this list may be supplemented by a number of additional studies. Thus, on the basis of the data obtained, the doctor will be able to identify contraindications that can potentially adversely affect the result of the IVF procedure.
If during the examination it is established that the cervix of the patient in the period of menopause has any pathology, then hysteroscopy will be prescribed by the doctor. Only on the basis of a general clinical picture, a reproductologist is able to predict the success of the upcoming manipulation of artificial insemination.
Important! The patient's partner is obliged to pass a semen analysis, as well as undergo tests for infections and blood tests.
Probability of success
The result of IVF in each case is extremely difficult to predict, even if the woman is at a young age and at the same time has no significant health problems. It happens that IVF repeatedly fails in young and perfectly healthy patients, while some women after 40 years from the first attempts successfully nurture and give birth to absolutely full-fledged children.
In any case, do not despair. After all, even if a woman will be diagnosed with any contraindications for IVF during menopause, or there will not be an increase in the endometrium, which in itself precludes the onset of pregnancy, it is always possible to use the services of surrogate motherhood. In this case, the female donor biomaterial is used, which is connected in the laboratory with the sperm of the partner of the barren woman, after which the developing embryo sits in the body of the surrogate mother.
IVF and artificial climax
The method of artificially interrupting ovarian function is called artificial menopause. The procedure is carried out with the participation of special hormonal drugs - at the same time for a time the hormones responsible for the formation of estrogen cease to be produced in the woman’s body. This procedure is used in cases when it is necessary to stop frequent uterine bleeding, or as a method to combat diseases of the female reproductive system (endometriosis, uterine myoma).
Unlike natural menopause, artificial menopause is reversible. In order for ovarian function to be resumed, a woman only needs to stop taking hormonal drugs. As a result, the cycle returns to normal, menstruation is restored. As a rule, artificial menopause does not last longer than 6 months. After the reproductive function returns to normal, the woman may well become pregnant on her own, or resort to the procedure of in vitro fertilization.
The reproduction department of Lazarev has already given many women in the period of menopause a chance to safely conceive and give birth to healthy children. Indeed, in our days, menopause does not at all mean the lack of an opportunity to feel the joy of motherhood, even for women in older age. Modern reproductive technologies, the latest equipment, an individual approach and high professionalism of our doctors are the main components of the success of our department. Our experience demonstrates with confidence - even women aged 40-50 years are quite capable of becoming mothers of healthy babies, and we are always ready to come to your aid!
Make an appointment with a fertility specialist
IVF with menopause: is it possible to postmenopausal it?
In Vitro Fertilization helps pregnant women who cannot do it naturally. Often, an early menopause becomes an obstacle to having a baby. But the existence of the IVF procedure gives a chance to become pregnant even to women who already have menopause. Especially, IVF is required for menopause in young women in whom menopause was artificially induced, for example, to stop the growth of any tumor.
The method of IVF during menopause
Thanks to the modern development of medicine for women who have entered a climacteric period, even in the complete absence of the natural maturation of the eggs, there is every chance of normal fertilization and successful childbearing.
In vitro fertilization can be made to a mature woman who has entered the climacteric phase using a donor material (oocyte). For this, an egg is taken from a healthy young woman, who is a donor in this case. With the help of a laboratory method, an egg taken is fertilized by the sperm of a woman’s husband.
When an ovum is fertilized by sperm, an embryo is obtained, which sits in the uterus of the recipient (the woman who will bear and give birth). But for its attachment and further development, a certain layer of the endometrium is needed, which is increased by taking drugs from the group of hormone replacement therapy.
In standard situations, women are initially prescribed estrogen-containing drugs to increase the endometrium, and then additional therapy is administered with the use of drugs based on gestagens. Hormone replacement therapy is recommended to continue in the period of childbearing.
The only thing after the growth and development of the fetus, the woman’s placenta begins to secrete hormone substances by itself, hormone replacement therapy is adjusted, during which hormone-containing medications can be simply adjusted with the lowest dosage or canceled altogether.
Necessary conditions for IVF
Naturally, in vitro fertilization is the only opportunity to give birth to a child and experience all the delights of maternal happiness for women who have reached the piquant age and have entered the threshold of hormonal restructuring of their bodies and the transition from the fertile period to the next stage of the life cycle. But for IVF, the female body must meet the following requirements:
- the absence of obvious contraindications of medical etiology that prevent this manipulation,
- no contraindications for taking hormone-containing drugs,
- the absence of various pathological tumors in the uterus, such as fibroids, fibroids and others,
- the physiological state of the uterine organ and the whole organism must be ready for independent bearing of the fetus.
It is important to remember that in most cases in the female body during menopause there are no mature eggs that can be fertilized and contribute to the occurrence of pregnancy. Therefore, a married couple should at a psychological level carefully approach the procedure and the use of donor cells.
Above, only the most basic points were considered, contributing to the admission of in vitro fertilization in a mature woman. Among other things, a woman must undergo a series of necessary examinations before performing the procedure. Based on the results obtained, the specialist evaluates the success of the procedure and gives an opinion on the permission or prohibition of IVF.
Exit from a failed IVF
Often, women who have reached the age of 50 can achieve a long-awaited pregnancy on the first attempt at carrying out the fertilization procedure and successfully endure it.
But sometimes for those who did IVF at a younger age, all attempts end in failure, despite all the ongoing treatment methods for increasing the endometrium. In the absence of the necessary layer of the endometrium pregnancy can not come. For such couples, there is another option to increase the composition of their family and to have a child - surrogate motherhood.
The meaning of surrogate motherhood is that a donor egg is fertilized by a man’s seminal fluid, and the resulting embryo is transplanted into the uterine cavity of a surrogate mother, which is under the supervision of specialists throughout pregnancy. After a successful delivery, the surrogate mother transfers the couple to the upbringing of their child. This method of finding true family happiness requires a careful approach and good psychological preparation of both spouses.
Probability of IVF after drug-induced artificial menopause
Artificial menopause occurs on the background of taking medications that contribute to the temporary cessation of the functioning of the female reproductive system of organs (in particular the ovaries) used to treat certain gynecological diseases of the female genital organs.
After therapy with hormonal drugs, and at the termination of their reception, mainly the functioning of the female reproductive system is restored, and the menstrual cycle is resumed in full or in part. This can contribute to the onset of natural pregnancy or the success of in vitro fertilization.
Responses of those women who had IVF during menopause and successful pregnancy and childbirth, for the most part, only positive. The method of in vitro fertilization allowed a multitude of married couples in adulthood to gain true happiness.
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