Monthly after regulon


Regulon is an oral hormonal contraceptive. The drug is used to treat hormonal dysfunctions, such as menstrual disorders and uterine fibroids in the initial stages. Hormonal drugs can trigger the absence of menstruation. To understand why the drug provoked the opposite effect, it is necessary to study its composition and understand the principles of the effects of components on the body.

Regulon - hormonal contraceptive in pill form

How does the drug

Regulon is intended for contraception and treatment of monthly cycle disorders, elimination of PMS, uterine bleeding, provoked by ovarian dysfunction or unstable hormonal background. A woman's pituitary gland produces hormones that are responsible for menstruation. When it is unstable, the cycle of menstruation is broken. The active components of Regulon act depressingly on the leinizing and follicle-stimulating hormones of the pituitary gland. This contributes to the inhibition of ovulation and creates a barrier to the penetration of sperm into the uterine cavity. Hormones inhibit the function of contraction of the fallopian tubes, which significantly reduces the rate at which eggs move through them.

The estrogenic element of the drug contributes to the compaction of mucus in the cervix and changes its qualitative composition. The environment in the cervix becomes more aggressive, contributing to the death of sperm.

Reduction of luteinizing and follicle-stimulating hormones slows down the complete formation of eggs, prevents the standard formation of the corpus luteum and rupture of the follicle, while the endometrial layer is formed in insufficient quantities. The standard thickness of the endometrium is 1 cm, and during the course of taking Regulon it does not exceed 4 mm. A fetal egg, even in the case when the egg cell and sperm cells have passed all previous stages of protection, cannot strengthen in the uterus, because the absence of a normally developed endometrium does not allow the number of vessels necessary for feeding the egg to form.

Features of the drug

Often, patients complain that they do not have menstruation after and during the reception of Regulon. The most common cause is incorrect drug intake. The contraceptive should begin to drink from 1 day of menstruation. With this technique does not require additional use of condoms. If the patient begins to receive from 2-5 days of menstruation, condoms should be used for 7 days. You can not start taking Regulon, if from the beginning of menstruation has elapsed 5 days.

Tablets should be drunk at one time, once a day. The risk of hyperovulation is reduced when, against the background of a surge in hormones, not one, but several eggs are formed. The break between reception is 23-25 ​​hours. If you are not sure that you will take the pills on time, set the alarm. When you skip one pill, you should take it if the skip time does not exceed 24 hours, otherwise the missed pill should be left and continue to be taken in standard mode, using condoms during intercourse.

In a pack of 21 tablets. After 3 weeks you need to take a break for a week. It is during this period should begin monthly.

The drug should be drunk at the same time of day.

How to stop taking contraceptives

Very often, the reason that after taking Regulon no menstruation, is the wrong end of the drug. Before abandoning the contraceptive, you should visit the doctor and consult if it is possible to cancel the appointment now, especially if Regulon was prescribed for medical purposes, or you decided to plan the birth of the child.

If the patient cancels reception in the middle of a cycle, without having finished a pack up to the end, it will surely entail certain consequences.

It can be severe uterine bleeding or complete absence of menstruation over a long period. If after the end of the medication there is no menstruation, then the recovery cycle will take a long time.

Cancellation of the drug should occur according to the scheme drawn up by a gynecologist. This scheme will be different in each case. It is based on:

  • goals
  • personal characteristics of the body,
  • course duration.

Disorders of the menstrual cycle when using the drug

Each has its own monthly cycle and it does not change with the beginning of the use of oral contraceptive (OK). During the course of hormone-based medication, each woman’s body will react individually, therefore, menstruation after taking 21 tablets may not come immediately. In the first 3 months of taking the drug, cycle violations may occur, while the body adapts and begins to function normally in the required mode. If after taking Regulon there are no menstrual periods within 10 days from the end of the pack, consult a doctor.

The reasons for this deviation from the norm can be varied.

  1. Pregnancy.
  2. Violation of the diet, strong weight loss.
  3. Stress.
  4. Intoxication. Vomiting or diarrhea after a woman has taken a pill.

The delay will be observed when hormonal changes change, due to the onset of pregnancy, or when hormones are redistributed during stress. Often fertilization occurs when Regulus is misused. Even if the pills have not been missed, taking them at different times with an interval of an hour can provoke the appearance of hyperovulation. In this case, one of the eggs reaches the destination on time, and the second comes out at the end of menstruation without covering the hormonal agent and quickly fertilizes.

The most unpredictable factor is intoxication. When observing the rules of application, vomiting and diarrhea (in case of malfunction of the pancreas) do not allow hormones to spread to the plasma. This occurs when 40 minutes have passed from the moment of taking the pill to vomiting or when there is severe diarrhea lasting for more than a day.

Strong stress provokes the release of hormones into the blood, disrupting the cyclical and already familiar rhythm of the body. Sharp weight loss, the most severe diets can provoke the absence of menstruation. Adipose tissue produces the female hormones estrogen. Women with too low weight very often go to doctors with complaints that they do not have periods. Fertilization with insufficient weight also does not occur, the body is not able to provide the embryo with the necessary amount of nutrients necessary for its full development.

The body's work after the termination of the application of OK

To understand why there is no menstruation after canceling OK, you need to understand the principles of hormone production before and after using them. At the end of the reception of Regulon, the body needs another restructuring. Ovaries and adrenal glands in the period of taking the drug practically do not work, because the body receives the necessary hormones from the outside. The production of hormones is reduced, and the organs need time to recover their work, so there may not be a period for a couple of months.

In addition to the failure of the monthly withdrawal of the drug provokes other changes:

  • hair loss, deterioration of their structural composition,
  • impaired recovery of epidermal cells (dryness, peeling, itching).

The menstrual cycle can change a lot. Firstly, the volume of blood loss increases, and secondly, the timing changes. If earlier monthly went 2–3 days, then after the course termination 5–7 days can proceed.

This is the first version of the body. After stopping OK, there is a second option, which is observed in most patients.

With long-term suppression of the functions of the pituitary gland, the body tries to work in the same mode and after discontinuation of hormones. The pituitary gland, without receiving a backlash, begins to stimulate additional production of follicle-stimulating and luteinizing hormones.

Enhanced pituitary gland improves the functionality of the ovaries. With such a harmonious work of the organs, the likelihood of pregnancy increases. OK allow you to cure some types of infertility.

After drug withdrawal, hair may begin to fall out.

No monthly after Regulon

You need to consult a doctor if there are no periods after the end of the course. Not only withdrawal syndrome, but also pregnancy can cause a delay. The reasons for the absence of menstruation after the abolition of medications are presented below.

  1. Amenorrhea - climax. OK cause this pathology extremely seldom. Only 3% of women of pre-menopausal age and young girls fall into the risk group. Disorders are caused by dysfunction of the endocrine and hormonal systems.
  2. Polycystic ovary or cystoma of the uterus.
  3. Oncology.
  4. Diseases of the genitourinary system of an infectious nature.

Final part

If there is no menstruation after the end of the course or while taking OK, you should definitely consult a doctor and undergo a full examination. First of all, an obstetric examination of the cervix is ​​performed, which allows you to determine the size of the ovaries and possible pathological formations on them.

Then an ultrasound and a blood test are indicated, showing the level of hormones. An additional examination may be prescribed, which will allow to determine ektsragenitalny pathology. If there is no menstruation, do not self-medicate. Sometimes for recovery after taking OK, additional vitamins and treatment are needed.

The effect of the drug on the body

The pituitary gland in the female body produces hormones that are responsible for critical days. In case of violation of the stability of the gland, the menstrual cycle is also lost.

The main components of Regulon (progestin, desogestrel, ethinyl estradiol) interfere with the action of pituitary hormones (luteinizing and follicle-stimulating). As a result, ovulation is suspended. The composition of this contraceptive contributes to reducing the contractile function of the fallopian tubes, and this makes it difficult for the egg to move through them.

Reducing the level of hormones necessary for ovulation, reduces the ability of the female germ cell to fully form, the process of rupture of the follicle and the formation of the yellow body is much more difficult. In addition, the hormonal hormones created as a result of the use of the contraceptive also affect the endometrium. If its usual thickness is 1 cm, then when receiving Regulon it reaches a maximum of 4 mm. Therefore, even if all the stages of fertilization were successful, the fetal egg will be very difficult to consolidate in the uterus.

How to take the drug

Regulon must be taken once a day at the same time. This reduces the possibility of hyperovulation when several eggs simultaneously mature under the influence of hormones. The optimal period between contraceptive use is 23–25 hours.

If for some reason you forgot or did not have time to take a pill on time, then you can still use it within a day after the pass. If more than 24 hours have passed, then it is better to use condoms during sexual contact. And then continue to use Regulon in its usual schedule.

After taking Regulon for 3 weeks (a pack of the drug is used during this time), it should be discontinued for 1 week. That's when critical days should come.

Violation of the menstruation cycle when using the drug

The menstrual cycle of each woman is individual, and at the start of oral contraceptive use, it may change. The reaction to the use of hormonal drugs is unpredictable, so it is not a fact that the monthly after Regulon will begin after the first pack of tablets. The first 3 cycles of “these days” may be delayed. This is because the body needs to adapt.

If, after taking Regulon's pack, the period does not appear for 10 days, you should go to the doctor. The reasons for the absence of menstruation may be as follows:

  • pregnancy,
  • severe stress
  • poor nutrition,
  • intoxication.

We conclude that the delay in critical days is normal in the first months of taking a contraceptive, but if it is too long or the periods do not come at all, it is worth visiting a gynecologist.

How the body behaves after stopping the use of the drug

Before you stop taking Regulon, you should consult with your doctor. This is especially important in the case of prescribing the drug for treatment or if you decide to have a baby. To cancel the use of this drug should be prescribed by the doctor.

It is strictly forbidden to interrupt the reception of a contraceptive in the middle of the course without finishing the pack. Otherwise, the consequences can not be avoided. This can be either heavy bleeding or lack of menstruation, which is very difficult to treat.

After the end of the contraceptive intake, the body is rebuilt, because now it needs to independently produce hormones that the drug provided. It takes time to rebuild the adrenal glands and the pituitary gland, so the delay after discontinuation of the drug Regulon is a normal phenomenon and it is not particularly necessary to be intimidated. For safety net you can always consult a qualified doctor.

Opinion of doctors

Doctors speak of Regulon very favorably and claim that they quite often prescribe it to their patients. After all, women talk about its effect in most cases positively, extremely rarely there are negative reviews.

It is very important to follow the instructions for use of the contraceptive, and in the event of any abnormalities, immediately listen to and perform what the doctor says.

Regulon is an oral contraceptive, which is used to normalize the menstrual cycle, as well as to protect against unplanned pregnancy.

Although the task of the drug and to establish a regular cycle, all the first months there may be a delay in menstruation after the application of Regulon. This is due to hormonal changes in the body. Other reasons for the lack of critical days are:

  1. Pregnancy.
  2. Wrong medication.
  3. Stress.
  4. Improper nutrition.

It is also necessary to cancel the use of Regulon correctly, because it can lead to negative consequences. If you want to stop using the drug, you should consult a doctor. Only in this way can it be used effectively, efficiently and without any special side effects.

General information about the drug Regulon

Regulon is a low-dose monophasic estrogen - progestin contraceptive. The contraceptive pharmacological effect of the drug is to inhibit the synthesis of follicular stimulating hormone (FSH) and luteinizing hormone (LH). Thus, the ovulatory rise of LH is blocked, and, accordingly, ovulation is blocked.

Regulone contains 30 μg ethinyl estradiol (estrogen component) and 150 μg dezogestrela (progestin component). It is the gestagen component that is involved in contraceptive effects such as:

  • A decrease in the rate of contraction of the fallopian tubes, which slows down the passage of the egg,
  • Suppression of the mitotic activity of the endometrium, which leads to its premature secretory transformation, and then to hypotrophy. All this violates the conditions for implantation of a fertilized egg.
  • Increased viscosity of the cervical mucus, which prevents the passage of sperm through the cervical canal.

The estrogenic component enhances the contraceptive effect of Regulon, and also improves the lipid profile, increasing HDL, and reduces androgen-dependent symptoms.

How do menstruation change when taking Regulon?

The first menstrual periods, which started after taking 1 tablet of Regulon, will continue as usual, and then for 2-3 cycles there will be a scanty discharge. At this time, menstruation may begin a little earlier or later. For three months, the female body adapts to the new level of sex hormones in the blood. Three months later:

  • stabilizes the menstrual cycle: the monthly will come from the 23rd to the 28th day of the cycle,
  • discharge becomes less plentiful and long
  • PMS symptoms disappear,
  • relieved pain syndrome.

Scanty monthly while taking Regulon

Monthly while taking contraceptives, including Regulon, become scarce and do not contain mucous inclusions. These changes occur under the influence of the main components of the drug. Ethinyl estradiol replaces the natural estrogen in a woman's body, and since its concentration is lower than normal in a woman, it does not ensure the proper proliferation of the endometrium. Endometrium does not grow more than 3-5mm. The progestogen component also affects the decrease in the volume of secretions: under the action of desogestrel, endometrial hypotrophy develops, that is, the size of the endometrial layer decreases and the number of blood vessels decreases.

Regulon and brown discharge

Minor brownish secretions can normally be observed at the beginning and at the end of menstruation. Brown discharge and clots do not stop for a long time under such pathological conditions as:

  • hormonal imbalance, including during the formation of the menstrual cycle or during menopause,
  • endometriosis, endometrial hyperplasia, polyps,
  • cervical erosion,
  • ectopic pregnancy,
  • inflammatory diseases of the reproductive organs,
  • sexually transmitted diseases
  • anorexia.

При приеме Регулона коричневые выделения считаются одним из побочных эффектов препарата. They occur against the background of oppression of the ovaries and as a result of an increase in the level of platelets in the blood.

I accept Regulon: why not monthly

The delay in menstruation while taking Regulon is possible in the first three months during the adaptation period of the female body to the drug. If while taking Regulon no monthly, you need to do a pregnancy test. With a negative result, you can continue to take the drug. In a certain percentage of women, menstruation may disappear, and this is a variant of the norm when taking Regulon. Perhaps this is due to the developed atrophy of the endometrium.

Regulon to delay the monthly

To delay the next bleeding, you need to take Regulon without a seven-day break between the first and second package of the drug. It is not recommended to delay menstruation for more than three cycles due to the possibility of breakthrough bleeding. Find out whether it is harmful to delay monthly oral contraceptives.

Valentina Lyapunova, general practitioner, specially for Mirmam.pro

Drug action

Regulon is an oral contraceptive consisting of ethinyl estradiol (estrogen component) progestin, desogestrel. The drug is prescribed for contraception, for the treatment of hormonal imbalances in the body. It is effective in the treatment of PMS, dysfunctional uterine bleeding.

The drug inhibits the hormones produced by the pituitary gland, which affect the normal flow of menstruation. The production of follicle-stimulating, luteinizing hormone is suspended under the action of gestagens. As a result, ovulation is inhibited, the sperm can not penetrate into the uterus.

Ethinyl estradiol tightens, changes the composition of mucus secreted in the cervix uterus. Sperm gets into the aggressive environment, it can not penetrate the uterus. At the same time, maturation of the egg cell is inhibited, the corpus luteum cannot develop normally, there is an obstacle to the rupture of the follicle. Endometrium develops in insufficient size. In a woman who does not take COCIs, the thickness of the endometrial layer normally reaches 1 cm. If oral contraceptives are accepted, the thickness of the layer is not more than 4 mm.

If the sperm and the egg can connect, despite the barriers that appear, the fetal egg simply cannot attach to the uterus, it will not receive the necessary nutrition from the thin endometrium. The action of Regulon extends, affects the fallopian tubes. Their contractility decreases, which causes a decrease in the rate of passage of the egg.

How to take

Regulon, like all oral contraceptives should be properly taken. This will eliminate the occurrence of undesirable consequences. Reception begins from the first day of the beginning of the menstrual cycle. If this rule is observed, the woman does not need additional contraception during sexual intercourse.

In some cases, the first pill must be taken during menstruation at 2-5 days. In this case, you need to take extra care about the means of protection. It is better to use the barrier method for another 1 week. It is forbidden to start taking Regulon if 5 or more days have passed after the end of menstruation. In this case, the reception is transferred to the beginning of the next cycle.

Every day at about the same time you need to take 1 tablet of blister. The established schedule prevents the risk of hyperovulation, a condition in which several eggs can mature on the background of a hormonal surge. The time difference for taking pills should not be more than 1 hour. Gynecologists recommend setting alarm clocks until a precise habit is developed.

If the pill was not taken on time, you need to drink it as soon as it comes to the realization of being late. If the period of the pass exceeds a day, you need to leave the forgotten pill, take the next one, but additionally use barrier contraception during sex.

It is necessary to take 21 tablets without a break, then take a break for 7 days. Monthly begin in this period. The next pack should start drinking after a week in the same way, even if your period is not over.

How to finish the course

Before you finish taking the drug, you need to consult with a gynecologist. A reguon can be appointed for medical purposes, so it is not always possible to finish its admission at any time.

It is forbidden to interrupt the administration of the drug in the middle of the pack, you need to finish all the pills, then refuse from further use of the pills. If you ignore the recommendation, you can provoke a failure of the menstrual cycle, which will then be restored for a long time. It is impossible to exclude uterine bleeding in such a situation.

Gynecologist will help to safely finish taking the medication by developing a special scheme for the woman. This takes into account the general state of health, the purpose for which the drug was prescribed, the total duration of its administration.

Monthly while taking medication

When taking Regulon, menstruation begins during the period of cancellation, when a woman drinks the last 21st pill and takes a break for 7 days. During the first 3 months, the organism adapts to the drug, there may be intermenstrual scanty discharge. This is not a reason for abrupt refusal to take pills and is considered the norm. For prevention, you can visit the gynecologist.

If after taking the last pill a week has passed and there is a delay in menstruation, you should consult a doctor. The reason may be hiding in the individual reaction of the body, hormonal failure. Pregnancy cannot be ruled out if the drug was disrupted.

Fear should cause a state where menstruation does not end at the usual time, there is a copiousness of discharge. It is forbidden to stop drinking pills by yourself, you must first consult a gynecologist, find the cause of the problem.

In the normal period, when Regulon is established within 3 months, the organism is fully adapted, the hormonal level is leveled. A woman notices relief, complete disappearance of PMS symptoms, decreases the intensity of pain during this period. The duration of menstruation may decrease, as well as profusion. In the presence of side effects, deterioration, bleeding, you need to consult a doctor. Self-treatment is strictly prohibited.

Changes in the body after discontinuation

During the reception of Regulon, the body receives hormones from outside, as a result, the work of the ovaries, adrenal glands is gradually inhibited, because for some time they are going to be oppressed. After the drug is discontinued, hormonal failure occurs, reorganization of the reproductive system begins. There may be a delay in menstruation, cycle failures.

An insufficient amount of the required hormones in the body not only leads to menstrual disorders. The condition of hair, nails worsens, the skin becomes dry, and rashes often occur. The nature of the monthly changes. They can be more abundant, long lasting.

There is another nature of changes in the body after the abolition of the contraceptive. When the suppression of the pituitary gland stops, it begins to work first in the former mode, and then with a double force, sending all the developed hormones directly to the ovaries, which were also in a "dormant" state for a long time. As a result, they are activated, enhancing the work. During this period, the chance of becoming pregnant increases, as women often aspire to. Oral contraceptives - an effective tool in the treatment of infertility.

Delay after cancellation of Regulon

Many women have unstable periods after the abolition of Regulon. This often occurs due to hormonal failure, called withdrawal syndrome. We can not exclude the occurrence of pregnancy, because the pituitary gland and ovaries begin to work twice as active. The possibility of fertilization will increase significantly.

In addition, the delay after taking Regulon can be caused by:

  1. Amenorrhea, climax. This pathology occurs in 3% of women taking the drug. Those who are on the threshold of menopause and girls of childbearing age fall into this category. Pathology develops due to the incorrect operation of the hormonal system.
  2. If menstruation should begin, but there is a delay, you cannot exclude uterine fibroids, polycystic ovaries.
  3. Diseases of oncological nature can be the cause of the absence of menstruation.
  4. Infectious diseases of the genitourinary system can cause a delay.

Normally, menstruation should go a few days after taking the last 21st tablet Regulon. If there is a delay, you should consult a doctor, find the cause of the problem. Self-treatment, ignoring the situation can cause the development of pathological processes in the body. A gynecologist will help determine the causes of delayed menstruation, sometimes ultrasonography, examinations and the course of vitamins are enough.

Regulon is an effective contraceptive with a healing effect. The drug is prescribed only by a gynecologist, the doctor also determines the discontinuation. Self-medication, violation of the recommendations for taking the drug can adversely affect the reproductive health of women.

What is fraught with Regulon's cancellation?

When taking Regulone pills, the hormonal system of a woman gets used to the fact that the adrenal glands and ovaries do not need to strain and work on the production of hormones, as they come from outside. With the abolition of taking Regulon in pills in the woman's body, serious changes begin to occur. The body needs a certain time in order to restructure itself and this may take several months.

The cycle can change a lot and there can be a normal situation when there is no menstruation after the cancellation of Regulon. This situation is observed in a significant proportion of women after refusing to take contraceptives, while talking about withdrawal syndrome. Perhaps another development in the form of changes in the nature of the flow of menstruation. If, while taking the drug, it was observed regularly and took 2–3 days, then after its exclusion it can last up to 7 days. On what day they come monthly and the nature of the discharge is impossible to predict.

After refusing to take Regulon pills, women often experience more than just failures in a previously adjusted monthly cycle. As a rule, the condition of the hair worsens, they become more fragile and there is a problem of their loss. The skin becomes dry, it may itch and peel. Women often begin to complain of mood swings, they have an increased sweat compartment, and the mammary glands may swell.

What causes a delay in menstruation?

Discontinuation of Regulon tablets is a frequent cause of the absence of a regul or cycle violation, but not the only one. According to common practice, a delay is considered a period of 10 days, after which it is necessary to apply for clarification of the reasons for its occurrence. The reason for this situation may be pregnancy, since refusing to take oral contraceptives increases the risk of its occurrence.

Among the common reasons for the absence of menstruation after the cancellation of Regulon include:

  • amenorrhea, menopause - the onset of the period and the refusal to take contraceptive coincide quite rarely, but according to statistics, occurs in 3% of women, violations in the cycle are caused by disruptions in the endocrine system and hormonal changes,
  • gynecological diseases - the delay can be caused by polycystic ovaries or a cyst of the uterus,
  • cancer pathologies - tumor formations can lead to a delay in menstruation and are often detected during examinations, there are hormone-dependent types of cancer, so taking contraceptives can speed up and give an impetus to their development,
  • infectious diseases - due to the negative impact of pathogenic flora on the urinary tract, malfunction of the reproductive system can be observed, gonorrhea, syphilis, and hepatitis are among the most common.

The nature of the discharge may be affected by the use of emergency contraception in the past, especially if it has been used more than 1 time per year. In some cases, the cycle can affect the reception of other drugs.

Sometimes the absence of menstruation can be directly related to the habits and lifestyle of a woman, affecting the hormonal background. In some cases, monthly disruptions are due to rigid diets and excessive exercise. The desire to lose weight dramatically can lead to a redistribution of estrogen in the body, since adipose tissue is closely associated with female hormones.

Lack of weight and a sufficient amount of body fat can cause a complete cessation of menstruation. In this regard, doctors do not recommend resorting to such methods of weight correction, since the result can be a whole list of negative consequences, ranging from metabolic disturbances and hormonal levels.

In rare cases, severe stress and emotional shock can lead to a lack of regulation. This does not directly affect the hormones, but due to neurological disorders, the occurrence of a cycle failure is possible.

Strong nervous stress can affect the release of enzymes in the blood and changes in hormonal levels.

What is important to consider when discontinuing the drug?

The action of the contraceptive pill is based on the suppression of the pituitary hormones responsible for the normal cycle of menstruation. The drug contributes to the oppression of ovulation and provides interference to the penetration of sperm into the uterus, which reduces the likelihood of pregnancy.

A barrier is achieved by changing hormonal levels, increasing the density of cervical mucus and changing its composition. After sexual intercourse is completed, the spermatozoa enter the environment that is aggressive for them and cannot freely reach their destination. The drug leads to inhibition of the process of maturation of the egg, deprives the corpus luteum the ability to develop normally and contributes to the rupture of the follicles. Normally, the thickness of the endometrium is 1 cm, taking Regulon reduces its value to 4 mm, which does not give the fetal egg a firm hold. In addition, the contraceptive reduces the ability of the fallopian tubes to reduce, which leads to a decrease in the rate of passage of the egg.

After the abolition of Regulon, the body loses such protection. In this case, the pituitary gland does not have time to reorganize, the ovaries resume their work, and against this background, the probability of becoming pregnant is high. This feature of the body is often used in case of conception problems, therefore contraceptives are often prescribed for these purposes.

In connection with such features, it is necessary to ensure that the absence of regulators and the delay are not associated with the onset of pregnancy. The probability of conception also increases in case of violation of oral contraceptive use, skipping even one pill can cause a splash of homons and overheating and lead to pregnancy.

The situation of skipping pills is not always associated with the forgetfulness of a woman, in some cases it can be predetermined by poisoning and vomiting, when a woman can not pay attention to the fact that as a result the body did not receive the required amount of the drug.

The situation of pregnancy on the background of taking Regulon is not critical, since the drug does not affect the health of the future baby.

Discontinuation of contraceptive drugs is quite a serious step. You can not interrupt the course at any desired time and stop in the middle of the package. It is necessary to drink all the pills, it is advisable to pre-consult a doctor. If you refuse the drug, you should resort to other methods of contraception, which will avoid unwanted conception. In order to make sure that the delay is not associated with pregnancy, it is enough to make a test or pass the analysis for hCG.

What should be done?

The reasons for not starting monthly regulon pills can be quite a lot. To exclude negative consequences, it is necessary to consult a doctor and undergo a complex of examinations. Finding out the true cause of the delay will help:

  • obstetric examination of the uterus, the identification of deviations in the size of the ovaries and formations,
  • Ultrasound,
  • blood test for hormones,
  • collecting smear on flora crops,
  • specific examinations for the determination of extragenital pathologies.

In the absence of regul, one cannot self-medicate and try to cause them artificially, since this is fraught with complications and bleeding. The body needs a certain time for the natural recovery process and the normalization of the reproductive system. In some cases, to restore the cycle of menstruation it is necessary to support the body in the form of prescribing a complex of vitamins or treatment.

Lack of regulation after refusing to take oral contraceptives is a common situation and occurs in a significant proportion of women. On which day the menstrual periods begin after discontinuation of Regulone pills depends on the individual characteristics of the organism and it may take several months to completely restructure the hormonal levels. Для исключения негативных последствий важно исключить иные причины задержки, в том числе беременность и развитие гинекологических заболеваний.


Если после отмены Регулона исчезли месячные, нужно не затягивать с походом к врачу. Специалист проведет обследование, определит уровень выработки и соотношение гормонов в крови.

Когда пациентка заканчивает принимать оральные контрацептивы, ее организм перестраивается. Under the influence of the drug, the work of the ovaries and adrenal glands significantly slows down, because the sex hormones regularly come with pills. To normalize the work of these bodies will take some time, sometimes 2 months or more.

The consequences of canceling OK besides delaying menstruation can be:

  • The deterioration of the hair, loss,
  • Dry skin
  • Peeling and itching.

The nature of the period also varies greatly. Bleeding may become more abundant, its duration will increase. While taking hormone pills, menstruation lasts only 2-3 days. After cancellation - 5-7 days.

However, such consequences do not occur in every patient. In some women, the functions of the depressed pituitary work remain after the drug is discontinued. This stimulates the production of hormones responsible for the production of follicles.

The functionality of the ovaries is improved, and the probability of successful fertilization increases significantly. Doctors often use courses Regulon for effective treatment of infertility.


A contraceptive is used orally to prevent unwanted pregnancy. Often, Regulon is prescribed by specialists for the treatment of many gynecological diseases, as well as for therapeutic purposes, in order to stabilize the menstrual cycle and the balance of hormones, stop vaginal bleeding, and compensate for the deficiency of progesterone.

This drug gives almost 100% guarantee of protection while strictly following the instructions.

Regulon is a round white pill in a shell labeled on each side of the P8 and RG. In the pharmacy you can buy one blister, consisting of 21 tablets, or a pack of three plates.


It is recommended to start taking Regulon from the first day of the menstrual cycle one tablet at the same time. Three weeks later, you should stop taking the funds for seven days. During this period, menstruation begins (usually for 2-3 days). Regulon should be resumed on the eighth day after the break. With strict adherence to the rules, the effectiveness of the components is maintained even during drug withdrawal.

Reception features

Duration as well as the method of application affects the effectiveness of contraception and therapeutic effects.

Primary use

It is necessary to start taking Regulon from the day the menstruation begins, further adhering to the above instructions.

You can use the pills from the second to the fifth day from the beginning of the menstrual cycle, but then you will need the help of other contraceptives in the first few days. You should not take the drug if it has already been more than five days from the start of menstruation. In this case, it is better to wait until the next cycle.

Use Regulon after childbirth

Women who do not breastfeed, can take a tablet of contraceptive drugs three weeks after the birth of the baby, before consulting with a gynecologist.

If more than 21 days have passed, then in the first week in parallel with the pills you need to use other methods to prevent conception.

A lady who has already had sexual intercourse after childbirth needs to postpone the start of the drug to the next month.

Pass admission funds

If less than 12 hours have passed since the moment of the missed pill, it is necessary to immediately correct the situation, namely, to take the medicine, and continue taking the drug according to the standard plan.

If the interval has exceeded 12 hours, it is recommended to use additional means of preventing pregnancy, since the effectiveness of Regulon could be reduced.

If you took the contraceptive pill for the first 14 days, you must take two pills at once, continuing to use the rest with the use of additional means of protection.

Having missed the reception on the third week, you need to complete the application of the rest and go to the new package, without taking a break.


The use of artificial sex hormone substitutes is a significant intervention in the body and may lead to some consequences. Before you assign yourself a contraceptive, you need to pass tests and consult with a gynecologist.

There are a number of contraindications for Regulon:

  • individual intolerance to the ingredients,
  • period pregnancy and lactation,
  • chronic liver ailments,
  • thrombosis,
  • diabetes,
  • migraine,
  • pancreatitis,
  • cholelithiasis,
  • vaginal bleeding unexplained origin
  • malignant tumors of the genitals and breasts,
  • smoking after 35 years.

Side effects

Without contraindications, adverse reactions are rare. Complications cause chronic diseases, uncontrolled use of drugs, overdose.

The appearance of the following pathologies is observed:

  • high blood pressure
  • heart attack, stroke,
  • thrombosis,
  • mammary cancer,
  • pancreatitis and jaundice,
  • possible hearing loss, otosclerosis.

The remaining reactions are not too serious and easily removable, but they appear more often.

These include:

  • migraine,
  • breast tenderness
  • vomiting
  • itching, rashes and other allergic reactions,
  • increased corneal sensitivity when using contact lenses,
  • metabolic disorder.

In such cases, the feasibility of termination of the use or replacement of the drug must be agreed with the doctor.

Monthly and Regulon

The tool reduces pain in the premenstrual period, helps to reduce menstrual flow and has a beneficial effect on the skin of the face.

If necessary, you can delay the monthly, continuing to take pills from the next package. A slight spotting may occur, but this will not affect the contraceptive effect of Regulon. After finishing the second package, you need to stop for seven days, then return to the reception in the usual way.

Discharges associated with the use of Regulon

The use of this drug is often the cause of the appearance of non-abundant secretions caused by the following factors:

  1. Reorganization of the reproductive system. The tool changes its work, which causes some resistance of the organism. This may manifest as a slight discharge in the middle of the menstrual cycle or more noticeable bleeding. The presence of such phenomena in the first three months is considered the norm. If they last longer, then the drug is better to replace, in consultation with the gynecologist.
  2. Lack of progestin, estrogen.
  3. Wrong reception. Regulon must be taken strictly according to the scheme. If the pill was missed or taken after a large interval, a reaction in the form of scanty discharge is possible. But it also happens when an unauthorized overdose occurs.
  4. Alcohol and smoking. The cause of bleeding can be a one-time use of strong alcoholic beverages in large quantities. Nicotine has a similar effect. This especially affects women after 35 years. Smoking tobacco weakens the contraceptive effect, which is expressed in the form of untimely discharge.
  5. Antibiotics, as well as other medicines can neutralize the effect of Regulon, thereby triggering a selection.
  6. Violation of the digestive tract. Vomiting or diarrhea will not give an opportunity to be absorbed by all the necessary components, and the effect of the drug will decrease to the level as if they forgot to take the pill.

Regulon does not cause secretions in absolutely all women, but if they arise, do not rush to panic prematurely and stop taking hormonal drugs. For starters, it is better to consult a doctor.


Regulon is a combination drug with therapeutic and contraceptive properties. Compliance with the instructions and precautions guarantees 100% prevention of unwanted pregnancy.

Despite the fact that oral contraceptives can be purchased at pharmacies without a prescription, every woman should take a responsible decision to take this type of medication, first get examined and consult a gynecologist.

Pharmacodynamics and pharmacokinetics

According to the abstract, the basis of the mechanism of action of the drug is the ability of its active substances. inhibit gonadotropin synthesis by the pituitary gland (in particular, luteinizing and follicle-stimulating hormones).

It makes it difficult ovulation, helps to increase the density of cervical mucus and, as a result, prevents the penetration sperm in inner space of the body of the uterus.

Ethinyl Estradiol is a synthetic analog estradiolwhich begins to be produced in the woman's body, starting with the first menstruation.

Desogestrel renders pronounced progestin and antiestrogenic effectsimilar to that provided by endogenous progesterone. Substance characterized by weak anabolic and androgenic activity.

During the period of taking the tablets Regulon in a woman (in the case of the original menorrhagia) significantly reduces blood loss during menstruation and improves the condition of the skin (especially in the presence of acne vulgaris).

AND desogestreland ethinyl estradiol and quickly and almost completely absorbed from the digestive tract. Desogestrel At once metabolized to form biologically active metabolite - 3-keto-desogestrel.

Plasma concentration reaches its maximum:

  • after 1.5 hours - for desogestrel (plasma concentration indicator - 2 ng in 1 ml),
  • after 1-2 hours - for ethinyl estradiol (an indicator of plasma concentration - 80 pg in 1 ml).

  • for desogestrel - from 62 to 81%,
  • for ethinyl estradiol - about 60% (this is due to presystemic conjugation and the effect of the first passage of the substance through the hepatic barrier).

  • for 3-keto-desogestrel - 30 hours (metabolic products excreted in the urine and intestinal contents in a ratio of 4: 6),
  • for ethinyl estradiol - 24% (about 40% of the substance and its metabolites are excreted in the urine, the remaining approximately 60% - with the contents of the intestine).

Indications for use

In the annotation to Regulon it is stated that the main purpose of the drug is to protect it from unwanted of pregnancy.

However, studies confirm that in addition to contraceptive effectRegulon is also characterized by the presence of a therapeutic effect. So, to the question “pills - what are they from?”, The instruction to the drug answers that the use of Regulon is advisable when dysfunctional uterine bleeding, premenstrual syndrome, dysmenorrhea etc..

The drug effectively relieves recurring aching pain in the lower abdomen, helps reduce the pain and profusion of menstrual bleeding, dispute, eliminates insignificant dark color from the genital tract in the perimenstrual period, as well as breast tenderness.

It is often prescribed to increase the effectiveness of endometriosis therapy. With uterine myome means prescribed to stop the growth of the tumor (it is advisable if the diameter of the latter does not exceed 2 cm). In addition, Regulon promotes resorption retention ovarian cysts.

After 40 years, when a woman, as a rule, has already resolved the issues of family planning and the birth of the required number of children, Regulon helps prevent abortion and its adverse effects (if you believe the statistics, most pregnancies at this age end in an artificial abortion).

Side effects of Regulon

The most dangerous side effects of Regulon, which require discontinuation of the drug, include:

  • arterial hypertension,
  • venous and arterial thromboembolism (including blood clots in deep veins, stroke, myocardial infarction etc.),
  • thromboembolism of veins and arteries of the liver and kidneys, and thromboembolism of the retinal and / or mesenteric veins and arteries (very rarely),
  • provoked otospongiosis hearing loss,
  • porphyrin disease,
  • hemolytic uremic syndrome,
  • exacerbation reactive systemic lupus erythematosus (in rare cases)
  • disappearing after cancellation of funds rheumatic chorea (in extremely rare cases).

The group of less serious side effects of the drug include:

  • non-menstruating acyclic bleedingas well as appearance bloody vaginal discharge,
  • noted after the cancellation of funds amenorrhea,
  • changes in the state of cervical (vaginal) mucus,
  • increase in tension and breast pain,
  • occurrence inflammation of the vagina,
  • thrush,
  • galactorrhea,
  • nausea,
  • vomiting
  • development or exacerbation of itchy and / or jaundice associated with cholestasis,
  • Crohn's disease (granulomatous enteritis),
  • cholelithiasis,
  • nodular or exudative erythema,
  • the appearance of lesions on the skin
  • chloasma,
  • headaches,
  • fickle mood
  • migraine,
  • depression,
  • hypersensitivity of the cornea,
  • decrease in tolerance (tolerance) to carbohydrates,
  • weight gain
  • fluid accumulation in the body
  • allergic reactions.

Birth control pills Regulon: instructions for use

How to take Regulon?

Pills begin to drink from day 1 menstrual cycle, one per day, at the same time of day, for 3 weeks (21 days). After the last pill is finished, it is necessary to sustain a seven-day interval during which bleeding, like menstrual bleeding, must pass.

On the 8th day after the last pill was finished (4 weeks after the start of the drug intake, on the same day of the week), even if the bleeding did not stop, the pill was resumed from the next blister.

How long can I take Regulon?

According to the above scheme, take the pills as long as the need for contraception remains. If a woman drinks pills, following all the rules and recommendations specified in the instructions for Regulon, contraceptive effect also persists during the seven-day interval.

The first pill

The first tablet of the drug is drunk on day 1 of the cycle. In this case, the use of additional methods of contraception is not necessary. If reception is started in the interval between 2 and 5 days of the cycle, then during the first 7 days of the first cycle of using Regulon one should resort to using barrier contraceptives.

If after the start menstrual bleeding more than 5 days have passed, it is advisable to start taking the drug in the next cycle.

How to drink Regulon after childbirth?

If a woman does not breastfeed, she can start taking pills 21 days after giving birth (after prior consultation with her gynecologist). In such a situation, the need to use additional contraception is absent.

If there is sexual contact after delivery, it is recommended to delay the start of taking Regulon until the next cycle.

If the drug begins to be taken later than 3 weeks after delivery, in the first 7 days of the first cycle of intake, additional contraceptive methods should be used.

Taking pills after abortion

If there are no contraindications, pills are allowed to drink as early as 1 day after abortion, and not complementing them with other contraceptives.

Regulon is also often prescribed after curettage.

The expediency of prescribing tablets after abortion / scraping (in particular, after missed abortion) due to the need restore normal ovarian function and prevent the development of inflammatory complications, which, according to statistics, occur in about one in three women who have undergone a repeated abortion.

Optimal means are drugs that include highly active progestinwhich does not have side effects, and, in particular, produced by Gedeon Richter tablets Regulon.

Taking the drug can compensate for the abortion deficit progesterone and development related proliferative processes in the reproductive system (including flowable tissue hyperplasia, polycystic ovary, adenomyosis, fibroids, endometrial hyperplasia, endometriosis, hypertecosis, mastopathy etc.).

Switching to Regulon from other hormonal drugs

When switching to a drug from another contraceptive, the first pill should be drunk the next day after completing a 28-day package (21 days of intake + 7 days break). There is no need to use additional contraceptives.

When switching to Regulon with mini drankThe first pill is taken on day 1 of the cycle, without supplementing the use of other methods of contraception.

If there is no menstrual bleeding during the period of taking the mini-drink, the Regulon can be started on any day of the cycle, but only after pregnancy is excluded.

In the first 7 days of the first intake cycle, there is a need for additional measures of protection, for which the condom is usually used, a cap with a spermicidal gel, or abstain from sex. The calendar method of contraception in this case is ineffective.

Delay of menstruation

When it is necessary to postpone menstruationpills continue to be taken without taking a break of 7 days. Deferred menstrual bleeding breakthrough bleeding or spotting may occur, which, however, do not reduce the contraceptive effect of the drug.

Regular intake of tablets is restored after a 7-day interval.

How to take Regulon when you skip a pill?

If, after skipping a pill, no more than 12 hours have passed, the forgotten pill is taken immediately after it is remembered. Further reception continues about the usual pattern.

If the interval between doses for more than 12 hours, the reliability of the drug in this cycle can not be considered one hundred percent. Therefore, before the next cycle should use additional contraceptives.

If you skip 1 pill in the first 7-14 days of the cycle, you should take 2 pills on the next day, after which you continue taking it in the usual way using additional contraceptives until the cycle ends.

If the pill was missed between 14 and 21 in the afternoon, continue to take it regularly, taking the forgotten pill and not taking a 7-day break.

If you skip the reception increases the risk ovulation and or appearance of bloody vaginal discharge. This is due to the fact that the composition of the drug includes a minimum dose estrogenand requires the use of additional contraceptives.


Symptoms of an overdose of Regulon are:

  • dyspepsia,
  • nausea,
  • vomiting
  • pronounced headache,
  • convulsionscalf muscles
  • non-menstrual bleeding from the vagina.

Since the drug does not have a specific antidote, symptomatic therapy is used to relieve symptoms of overdose. First aid after taking a high dose of Regulon is gastric lavage (it is recommended to do it in the first two or three hours after taking the pills).


The effectiveness of oral contraceptives is reduced in combination with drugs that induce liver enzymes: rifampicin, hydantoin,carbamazepine, barbiturates, oxcarbazepine, felbamate, primidone, topiramate, Hypericum ordinary, griseovulfin.

In addition, used in combination with Regulon, these drugs increase the likelihood of breakthrough bleeding.

The induction level reaches a maximum not earlier than 2-3 weeks later, however, it may persist up to 4 weeks after discontinuation of the drug.

Violation of the menstrual cycle and a decrease in the contraceptive effect may be observed when used simultaneously with:

  • antibiotics (especially with tetracycline and ampicillin),
  • barbiturates,
  • by some antispasmodic,
  • laxatives,
  • antidepressants.

In the case when the use of the above preparations is necessary, it is recommended to be protected withbarrier contraceptives (during the entire period of treatment, as well as for an additional 7-28 days, depending on which medication was prescribed).

If necessary, use anticoagulants during the reception of Regulon it is necessary to conduct additional monitoring of prothrombin time. In some situations, you may need to adjust the dosage regimen. anticoagulant.

Due to the increased likelihood of complications, do not combine Regulon withhepatotoxic drugs.

While taking oral contraceptives can:

  • decrease carbohydrate tolerance,
  • increase the need for oral antidiabetic drugs and insulin.

special instructions

If taking Regulon is accompanied by a deterioration in liver function tests, it is recommended to immediately stop taking the pills.

In the first few months of taking the drug may occur. acyclic intermenstrual bleedingwhich are not a reason for the cancellation of tablets. However, if they continue for three months or more, it is necessary to undergo a detailed examination.

Since women smokers Regulon intake is accompanied by an increased risk thromboembolic complicationsThey are encouraged to resolve the issue of smoking cessation.

If the monthly period after Regulon does not occur in the second cycle, the probability of pregnancy should be excluded.

The teratogenic effect of Regulon has not been proven. For this reason, if a pregnancy occurred while taking the pills, there is no need to interrupt it.

How long can I take Regulon?

During the period of taking Regulon, changes characteristic of the first weeks occur in the woman's body.of pregnancy. A woman who already has children in the reproductive system has the same processes that would have occurred if she had given birth and fed several children.

It is well known that the birth of a large number of children is the most effective method of protection against oncological diseases of the reproductive system and mammary glands.

Thus, long-term use of Regulon enhances the therapeutic effect of the drug. Taking pills is allowed until the woman has a question of planning a child.

Regulon and monthly

Usually, menstrual bleeding when taking Regulon becomes more scarce. However, it also happens that a woman may develop an addiction to the drug, which is most often manifested in the form of a heavy discharge.

Termination of the same pill is usually accompanied by increased workovary. Therefore, one of the consequences of the abolition of Regulon can be very heavy menstrual bleeding.

If there is no menstruation after the cancellation, this may also be due to failure of ovarian function. As a rule, she and therefore menstrual cycleThey are restored a month after discontinuation of Regulon. To determine the level of hormones in the body, gynecologists recommend to pass the necessary tests after a month after discontinuation of the drug.

Regulon and weight: do they get fat from hormone pills?

It is believed that the reception hormonal contraceptives able to provoke an increase in body weight. However, doctors say that with all the rules for taking Regulon, as well as the daily regimen and nutrition, the pills have no effect on the woman’s weight.

Usually, weight gain on the background of taking birth control pills may be due to the fact that their composition desogestrel characterized by the ability to retain fluid in the body (for example, it is progesterone that causes edema during pregnancy).

The hormones contained in Regulon help to accelerate biochemical reactions lipids and carbohydrate. If the level of physical activity is assessed as sufficient, the extra calories are easily converted into energy, but with insufficient loads, they settle on the body in the form of extra pounds.

Can I get pregnant while taking the drug?

With proper use of Regulon, the probability of pregnancy is negligible. The effectiveness of the drug is very close to 100%.

The risk of becoming pregnant is highest during the period of a contraceptive change, in cases where there were misses of taking the pills, violations of the regimen (pills were taken each time at different times) and also if the pill was neutralized (for example, with an absorbent).

Which is better - Regulon or Novinet?

Regulon and Novinet - These are generic drugs. They have the same composition, indications for use and contraindications, but are produced by different companies.

Regulon or Janine - which is better?

And Regulon, and Janin - this low-dose monophasic contraceptives. They have a similar mechanism of action, but differ in composition. Regulon is a combination ethinyl estradiol and desogestrel, and in the composition of Zhanin ethinyl estradiolsupplemented dienogest (with the dose progestogenic the ingredient in Janine dragee is slightly higher than in Regulon).

The most significant difference between drugs is their price - Regulon costs significantly less than its counterpart.

Regulon and pregnancy

Pregnancy is an absolute contraindication to the appointment Regulon. During lactation, you should refuse to take the drug or stop breastfeeding.

This is due to the fact that taking the pills in the postpartum period causes a decrease in the amount of milk, worsens lactation and adversely affects the growth of the child.

Pregnancy after birth control pills Regulon

Contraceptive effectRegulon tablets are associated with the ability of its synthetic counterparts endogenous hormones estradiol and progestogensprevent the release of a mature egg from the follicle.

As contraception the drug is allowed to use for several years. However, many women are worried about whether this will somehow affect the reproductive function and subsequent pregnancy.

Gynecologists answer these questions like this: if you take the pills correctly (that is, take it according to the scheme described in the instructions and in compliance with all the recommendations of your doctor), then upon completion of their admission you can plan the pregnancy. Usually, pregnancy after Regulon occurs after about 6 months of active sex life.

A woman who plans a child, doctors recommend to stop taking the drug at least three months before conception.

Reviews on Regulon

Birth control pills Regulon - reviews are evidence of this - this is one of the most popular contraceptive methods.

The majority of women taking them notes a small number of side effects of the drug, its reliability, an affordable price, and the fact that pregnancy after pill withdrawal occurs without any problems (on the forums, those who become pregnant after Regulon leave a considerable amount of positive feedback about this tool).

Nevertheless, there are negative reviews about the side effects of Regulon. They are usually associated with the appearance of acyclic bleeding of varying degrees of intensity, itching in intimate areas, nausea, and weight gain.

Turning to the reviews of doctors about Regulon, it can be concluded that such phenomena are most often caused by intolerance to any component of the tablets, or by the fact that the drug is simply not suitable for a particular organism. To minimize side effects, it is recommended to follow the instructions for use of the tablets.

If there is no improvement in this case either, it is worth resolving the issue of drug withdrawal, undergo the necessary examinations and select another contraceptive method.

Price Regulon

Price Regulon in Ukraine

The cost of the drug in major cities of Ukraine (for example, in Kiev or in Kharkov) is UAH 158-175 per package No. 21. Buy the package number 63 can be an average of 450 UAH.

It is possible to find out more precisely how much a Regulon pharmacy costs through the Internet.

Price Regulon in Russia

The price of contraceptive pills Regulon No. 21 in Russian pharmacies - 337-410 rubles. Packing number 63 costs an average of 947 rubles.

Related topics

Hello! I am 22 years old I have a cystic formation on both sides, and I also have a violation of the cycle, the doctor prescribed me a regulon and I read the instructions and the hair stood on end, I was so afraid to get better and some tumors that I was afraid to drink it, I’m not afraid of nausea I am very scared and so after birth I weigh 58 kg while my height is 1.61. Could you tell me please how often do women gain weight from a regulon? and how often there are tumors and a terrible rash on the body?

It became very interesting about the statement of the first guest that Regulon kills the ovaries, as the doctor assigned them to me for half a year to restore the cycle after the operation on the ovary.
I have already taken 21 pills and so far only my chest has increased.

I am concerned about the issue of unwanted pregnancy. 3 months I took regullon, menstruation always came on the 4th day after cancellation. except for the regulon, condoms and PPA were protected at the same time. After the drug was discontinued, the chest, drowsiness, weakness, and 6 pieces of tests from different manufacturers were sore and swelled, if I am negative, can I be pregnant.

I am concerned about the issue of unwanted pregnancy. 3 months I took regullon, menstruation always came on the 4th day after cancellation. except for the regulon, condoms and PPA were protected at the same time. After the drug was discontinued, the chest, drowsiness, weakness, and 6 pieces of tests from different manufacturers were sore and swelled, if I am negative, can I be pregnant.